沈承勇实验室
沈承勇
研究员,博士生导师
研究领域:神经突触及运动神经环路发育成熟的生理机制,
神经突触疾病(如运动神经元病ALS,肌肉萎缩症,额颞痴呆等)病理机制及转化应用

代表性论著

1. Chen A, Bai L, Zhong K, Shu X, Wang A, Xiao Y, Zhang K, Shen C#. APC2CDH1 negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7. FASEB J. 2020 Jul 20

2. Xiao Y, Zhang J, Shu X, Bai L, Xu W, Wang A, Chen A, Tu WY, Wang J, Zhang K, Luo B#, Shen C#. Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment. Hum.Mol.Genet. 2019

3. Wang J*, Xiao Y*, Zhang K, Luo B#, Shen C#. Introducing autoimmunity at the synapse by a novel animal model of experimental autoimmune myasthenia gravis. Neuroscience. 2018,15;374:264-270

4. Shen C*,#(共通讯), Li L*, Zhao K*, Bai L*, Wang A, Shu X, Xiao Y, Zhang J, Zhang K, Hui T, Chen W, Zhang B, Hsu W, Xiong WC, Mei L#. Motoneuron Wnts regulate neuromuscular junction development. eLife. 2018 Aug 16;7

5. Zhao K*, Shen C*# (共一作/共通讯), Li L, Wu H, Xing G, Dong Z, Jing H, Chen W, Zhang H, Tan Z, Pan J, Xiong L, Wang H, Cui W, Sun XD, Li S, Huang X, Xiong WC, Mei L#. Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. J.Neurosci. 2018 Aug 30 (cover)

6. Tao Y*, Shen C*,# (共一作/共通讯), Luo S*, Traoré W*, Marchetto S, Santoni MJ, Xu L, Wu B, Shi C, Liu X, Zhao K, Xiong WC, Borg JP#, Mei L#. Role of Erbin in ErbB2-dependent breast tumor growth. PNAS. 111(42):4429-38, 2014

7. Shen C, Xiong WC, Mei L. LRP4 in neuromuscular junction and bone development and diseases. Bone. Nov;80:101-8, 2015

8. Shen C*, Lu Y*, Zhang B*, Figueiredo D, Bean J, Jung J, Wu H, Barik A, Yin DM, Xiong WC, Mei L. Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis. J.Clin.Invest. 123:5190-202, 2013.

9. Shen C, Xiong WC, Mei L. Caspase-3, shears for synapse pruning. Dev.Cell. 28:604-606, 2014 (Preview) 

10. Tao Y*, Chen YJ*, Shen C* (共一作), Lee D, Marchetto S, Gao TM, Borg JP, Xiong WC, Mei L. Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons. Nat. Neurosci.16:290 -299, 2013

11. Zhang B*, Shen C* (共一作), Bealmear B, Ragheb S, Xiong WC, Lewis R, Mei L. Autoantibodies to agrin in myasthenia gravis patients. PLOS.One. 9(3), 2014

12. Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J.Biol.Chem. 283:17721-30, 2008

浙江大学转化医学研究院
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