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Prof. Yi Li and Prof. Pumin Zhang Visited ITM

Editor:admin Date:2016-10-24 Hits:591

Prof. Yi Li and Prof. Pumin Zhang visited the Institute of Translational Medicine (ITM) together on 28th June, 2016. They made vivid academic presentations on both topics of Molecular mechanisms underlying breast cancerformation and progressionand Control of Genome Stability by APC.

Prof. Yi Li is a tenured professor at the Lester & Sue Smith Breast Center, Baylor College of Medicine.  He studies the molecular and cellular mechanisms of breast cancer initiation and evolution as well as breast cancer prevention. His laboratory pioneered the use of the RCAS-TVA avian retroviral system for modeling sporadic breast cancer in mice, delineated anticancer barriers during breast cancer initiation, discovered a molecular mechanism underlying increased breast cancer risk caused by late-age first pregnancy, and established intermittent anti-STAT5 for preventing breast cancer.

Prof. PuminZhang is a molecular biologist with expertise in cell cycle regulation, cell cycle checkpoints, genome stability, and tumorigenesis. He has extensive experience in the analysis of mouse models. Publications from the laboratory include work on dissecting the function of cell cycle inhibitors, DNA damage response regulators, and spindle assembly checkpoint in mice. His lab discovered the aneuploidy checkpoint that responds to abnormalities in karyotypes. Prof. Zhang is an expert in molecular engineering. He invented a way of cloning large pieces of mouse genomic DNA for the purpose of constructing knockout vectors which was published in Nature Genetics and granted a US patent. The Zhang research group contains students and postdocs. The laboratory offers a highly interdisciplinary training ground for students interested in using in vitro and in vivo models to solve pressing medical and health problems.