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Wei Chen - Personal Profile

WEI CHEN

ADDRESS

Institute of Translational Medicine&Children's hospital affiliated, Medical School

Zhejiang University, Hua-Jia-Chi Campus
268 Kai-Xuan Road
Hangzhou, 310029,
P.R.China
chenwei001@zju.edu.cn

 EXPERIENCES

2013.9-now               Institute of Translational Medicine&, Children's hospital affiliated, Medical School, Zhejiang University

2010.9-2013.9          Renji HospitalShanghai Jiao Tong University School of Medicine,  Associate professor

2009.11-2010.8       Waisman Center, University of Wisconsin-Madison

2004.11-2009.9       Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield

2003.3-2004.11       Research Associate, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, and Stem Cell Gene Engineering Co., Ltd. Tianjin, China)

1999-2002               Institute of Genetics and Developmental Biology, ChineseAcademy of Sciences

1996-1999               Developmental Biology, Institute of Developmental Biology, Shandong University, Jinan, China. Developmental biology

 EDUCATION

1999-2002             Ph. D., Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

1996-1999             Master of Science, Developmental Biology, Institute of Developmental Biology, Shandong University, Jinan, China 

INTEREST

The research interest of Chen’s lab focus on understanding the mechanisms of neural development, modeling neural disorders and harnessing the potential of neural regeneration with stem cells. The project is related to the congenital and acquired disease and animal model in the inner ear, intestine, central nervous system and spinal cord.

We isolated and characterized the first human auditory cell lines with the expression of pluripotent markers and the capacity of self-renewal(Chen et.al, Stem cells, 2009). Secondly auditory-evoked response thresholds were significantly improved when we transplanted the sensory progenitors into the hearing loss gerbil model induced from human embryonic stem cells. These results should stimulate further research into the development of a cell-based therapy for deafness(Chen et.al, Nature, 2012).

 Except the hearing area, we are also interested in the neural regeneration of central nervous system disease and injury. With the transplantation of Human-derived neural progenitors, astrocytes were replaced in adult mice with partially restored function in spinal cord (Chen H. et.al, JCI, 2015).

INVITED SPEECH

2012Beijing Otology Forum-2012 IAPA, Invited as speaker for the topic of “Human Stem Cell and Deafness Therapy”.

Bit’s 5th annual world congress of regenerative medicine and stem cell-2012, Invited as speaker for the topic of “Restoration of auditory evoked responses by human ES cell-derived cochlear progenitors”.

2015Xi'an, Predisposing factors Workshop about Sensory hearing loss, Invited as speaker for the topic of “Cell therapy and auditory neuropathy”

2015 ShenzhenForum of Auditory scienceFrom hair cell to cerebral cortex Invited as speaker for the topic of “Cell therapy and auditory neuropathy”

 HONORS

2012, the bachelor student in my duty harvested the "Student Meritorious Paper" Award in Shanghai Jiao Tong University.

2002, First Scholarship for Di Ao, Chinese Academy of Sciences, Beijing, China

2002, Scholarship for Excellent paper, institute of Genetics and Developmental Biology

1998, Scholarship for Excellent Graduate, Shandong University

PUBLICATIONS and PATENTS:

 1. Chen, H. Qian, K. Chen, W. Hu, B. Blackbourn, L. W. th Du, Z. Ma, L. Liu, H. Knobel, K. M. Ayala, M. Zhang, S. C." Human-derived neural progenitors functionally replace astrocytes in adult mice" J Clin Invest. 2015;125(3):1033–1042. doi:10.1172/JCI69097.

2.    Chen, W; Jongkamonwiwat(equal contribution), N; Abbas, L; Jacob Eshtan, S; Johnson, SL; Kuhn, S; Thurlow, JK; Andrews, PW; Marcotti, W; Moore, HD and Rivolta, MN. Restoration of auditory evoked responses by human ES cell-derived cochlear progenitors. Nature. 2012 Oct 11;490(7419):278-82. doi: 10.1038/nature11415. Epub 2012 Sep 12.

3.    Boddy, SL; Chen, W☆(☆Equal Contribution Romero-Guevara, R; Kottam, L; Bellantuono, I and Rivolta, MN. Inner ear progenitor cells can be generated in vitro from human bone marrow mesenchymal stem cells. Regenerative Medicine, 2012 Nov; 7(6):757-67. doi: 10.2217/rme.12.58.

4.    Chen W, Johnson S., Marcotti W., Andrews PW., Moore HD, Rivolta MN. Human Fetal Auditory Stem Cells can be expanded in vitro and differentiate into functional auditory neurons and hair cell-like cells. Stem Cells, 2009 May; 27(5):1196-204.

5.    Chen W, Cacciabue-Rivolta DI, Moore HD, Rivolta MN. (2007). "The human fetal cochlea can be a source for auditory progenitors/stem cells isolation."

6.    Chen W., Lu M. DNA chip for diagnosing phenylketonuria (Application Number, 200410072621; Publication Number: CN1696308; Approval Pub. Date: 2007.02.28; Granted Pub. Date2007.02.28; International Classification: C12Q1/68; Applicant Name: Xiehe Stem Cell Gene Engineering Co., Ltd., Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China)

7.   Lan, L. , Chen, W. (equal contribution), Lai, Y., Suo, J., Kong, Z., Li, C., Lu, Y., Zhang, Y., Zhao, X., Zhang, X., Han, B., Cheng, J., Xue, Y. (2004) Monitoring of gene expression profiles and isolation of candidate genes involved in pollination and fertilization in rice (Oryza sativa L.) using a 10K cDNA microarray.

8.    Feng, Q. Zhang, Y. Hao, P. Wang, S. Fu, G. Huang, Y. Li, Y. Zhu, J. Liu, Y. Hu, X. Jia, P. Zhang, Y. Zhao, Q. Ying, K. Yu, S. Tang, Y. Weng, Q. Zhang, L. Lu, Y. Mu, J. Lu, Y. Zhang, L. S. Yu, Z. Fan, D. Liu, X. Lu, T. Li, C. Wu, Y. Sun, T. Lei, H. Li, T. Hu, H. Guan, J. Wu, M. Zhang, R. Zhou, B. Chen, Z. Chen, L. Jin, Z. Wang, R. Yin, H. Cai, Z. Ren, S. Lv, G. Gu, W. Zhu, G. Tu, Y. Jia, J. Zhang, Y. Chen, J. Kang, H. Chen, X. Shao, C. Sun, Y. Hu, Q. Zhang, X. Zhang, W. Wang, L. Ding, C. Sheng, H. Gu, J. Chen, S. Ni, L. Zhu, F. Chen, W. Lan, L. Lai, Y. Cheng, Z. Gu, M. Jiang, J. Li, J. Hong, G. Xue, Y. Han, B. Sequence and Analysis of Rice Chromosome 4. Nature. 2002, 420, 316–320.

9.    Chen, W., D. Tang, et al. (2001). "Expressional profiling of genes related to pollination and fertilization in rice." C R Acad Sci III 324(12): 1111-6.

 

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