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史鹏

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史鹏简介

联系方式

浙江省杭州市西湖区余杭塘路866号医学院科研楼C520 310058

Email: Ship@zju.edu.cn

教育背景

2002-2017          美国德克萨斯大学圣安东尼奥医学中心 (University of Texas Health Science Center at

                            San Antonio)        博士      生理专业

1996-2001          泰山医学院        学士      临床医学

科研经历

2016/4-至今       浙江大学转化医学研究院浙江大学第二附属医院            研究员

2012/8-2016/4    美国西达赛奈医学中心(Cedars Sinai Medical Center    助理教授

2011/7-2012/7    美国佛罗里达大学(University of Florida                          助理教授

2007/12-2011/6  美国佛罗里达大学(University of Florida                          博士后

研究兴趣与方向

1.        小胶质细胞(Microglia)介导的神经炎症对心血管的调控机制

2.        Microglia活性状态的调控机制;以及其对自主神经活性的调节作用

荣誉及奖励

2000        Japan AIEJ scholarship

2006        Vernon S. Bishop Graduate Student Research Travel Award in UTHSCSA

2009    American Heart Association Postdoctoral Fellowship Award

2011    Physiological Genomics Group/Featured Topic Travel Award

2011    American Heart Association Scientist Development Grant Award

2011    American Heart Association Annual High Blood Pressure Research Conference New Investigator Award

2012    American Physiological Society/Neural Control and Autonomic Regulation Section Postdoctoral and Early Career Research Recognition Award

主持会议

1. Neural Control &Autonomic Regulation Section (NCAR) Trainee Featured Topic

Experimental Biology Conference; Boston, MA, USA                     2013/4

2. Novel Roles of Neuro-Glial Communication in Central Cardiovascular Control

FASEB Science Research Conference; Portland, OR, USA            2013/7

受邀学术机构报告

1. "Microglial-neuronal interactions in the brain" 

University of Central Florida                             2012/2

2. " Neuroinflammation and hypertension in the paraventricular nucleus" 

Cedars-Sinai Medical Center                            2012/4

3.  " Microglial-neuronal interactions in the brain during hypertension"

Louisiana State University                                2012/5

特邀国际学术会议报告

1."Microglial activation by the brain Renin-Angiotensin System"

Experiment Biology, Washington, D.C., USA                                      2011/4

2. “Stimulatory action of the renin-angiotensin-aldosterone system on the production of microglial derived cytokines

65th High Blood Pressure Research Conference, Orlando, FL, USA    2011/9

3. “Role of microglia in neurogenic hypertension” 

FASEB Neural Mechanism in Cardiovascular Regulation Science Research Conference

Portland, OR, USA                                                                           2013/7

4." Microglia: A new cellular factor, in the development of hypertension

Experiment Biology, San Diego, CA, USA                                         2014/4

5. " Microglia participate in neurogenic regulation of hypertension”

Experimental Biology, San Diego, CA, USA                                      2016/4

发表文章

编书Book Chapter:

1.       Guingab, J.D., Kobeissy, F.H., Ratliff, M., Shi, P, Zhang, Z., Wang, K.K.W. Neurogenomic and neuroproteomic approaches to studying neural injury in "essentials of spinal cord injury."(Eds.. Fehlings,. Vaccaro,. Boakye,. Rossignol,. Ditunno, and. Burns), 2010. Thieme Publishers.

综述Review Articles:

1.      Koronyo-Hamaoui M, Shah K, Koronyo Y, Bernstein E, Giani JF, Janjulia T, Black KL, Shi P, Gonzalez-Villalobos RA, Fuchs S, Shen XZ, Bernstein KE. ACE overexpression in myelonibicytic cells: effect of a mouse model of Alzheimer’s disease. Curr Hypertension Rep. 2014 Jul; 16(7):444. PMID: 24792094.

2.      Bernstein KE, Gonzalez-Villalobos RA, Giani JF, Shah K, Bernstein E, Janjulia T, Koronyo Y, Shi P, Koronyo-Hamaoui M, Fuchs S, Shen XZ. Angiotensin converting enzyme over expression in myelocytes enhances immune response. Biological Chemistry, 2014, March, PMID: 24633750.

3.      Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell W-LB, Shah KH, Taylor BL, Shi P, Fuchs S, Bernstein KE. Rediscovering ACE: Novel insights into the many roles of the angiotensin-converting enzyme. Mol. Medicine (Berlin), 2013 Oct; 91(10): 1143-1154. PMID: 23686164.

4.      de Kloet AD, Krause EG, Shi P, Zubcevic J, Raizada MK and Sumners C. Neuroimmune communication in hypertension and obesity: A new therapeutic angle? Pharmacology & Therapeutics. 2013 Feb; 138(8):428-40. PMID: 23458610.

5.      Shi P, Raizada MK, Sumners C. Brain cytokines as neuromodulators in cardiovascular control.Clin Exp Pharmacol Physiol. 2010 Feb; 37(2):e52-7. PMID: 19566837.

研究论文Research Articles:

1.     Li Y, Shen X Z, Li L, Zhao T, Kenneth E. Bernstein, Alan K. Johnson, Patrick Lyden, Jianmin Fang and Shi P. Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation[J]. Stroke, 2017:STROKEAHA.117.017370. 

2.        Liu M, Shi P and Sumners C. Direct anti-inflammatory effects of angiotensin-(1-7) on microglia. J Neurochem. 2016 Jan; 136(1):163-71. PMID: 26448556.  

3.        Shah KH, Shi P, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE and Shen XZ. Myeloid suppressor cells accumulate and regulate blood pressure in hypertension. Circ. Res. 2015, August; 117(10):858-69. (Editorial: Circ Res. 2015; 117(10):830-1) PMID: 26294657.

 4.        Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P and Shi P.  Microglia participate in neurogenic regulation of hypertension. Hypertension. 2015, April; 66(2):309-16. (Editorial: Hypertension. 2015; 66(2):256-6) PMID: 26056339.

 5.        Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK and Sumners C. Direct pro-inflammtory effects of prorenin on microglia. PlosOne. 2014, Oct; 10;9(10):e92937. doi: 10.1371 PMID: 25302502.

 6.        Shan Z, Zubcevic J, Shi P, Jun JY, Dong Y, Murca TM, Lamont GJ, Cuadra A, Yuan W, Qi Y, Li Q, Paton JF, Katovich MJ, Sumners C and Raizada MK. Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat. Hypertension. 2013, June; 61(6):1328-33. PMID: 23547238.

 7.        Jiang N, Shi P, Desland F, Kitchen-Pareja MC and Sumners C. Interleukin-10 inhibits angiotensin II-induced decreases in neuronal potassium current. Am J Physiol Cell Physiol. 2013, April; 304(8):C801-7. PMID: 23426971.

 8.        Zubcevic J, Jun JY, Lamont G, Murça TM, Shi P, Yuan W, Lin F, Carvajal JM, Li Q, Sumners C, Raizada MK, Shan Z. Nucleus of the solitary tract (Pro)renin receptor-mediated antihypertensive effect involved nuclear factor-κB-cytokine signaling in the spontaneously hypertensive rat. Hypertension. 2013, March; 61(3):622-7. PMID: 23319541.

 9.        Colombari E, Colombari DS, Li H, Shi P, Dong Y, Jiang N, Raizada MK, Sumners C, Murphy D, Paton JF. Macrophage migration inhibitory factor in the paraventricular nucleus plays a major role in the sympathoexcitatory response to salt. Hypertension. 2010 Nov;56(5):956-63. PMID: 20937969.

 10.     Cao W, Glushakov A, Shah HP, Mecca AP, Sumners C, Shi P, Seubert CN, Martynyuk AE. Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. Amino Acids. 2011 Apr;40(4):1151-8. PMID: 20839013.

 11.    Shan Z*, Shi P*, Cuadra AE, Dong Y, Lamont GJ, Li Q, Seth DM, Navar LG, Katovich MJ, Sumners C, Raizada MK. Involvement of the brain (pro)renin receptor in cardiovascular homeostasis. Circ Res. 2010 Oct;107(7):934-8. PMID: 20689062. *co-first author.

 12.    Shi P, Diez-Freire C, Jun JY, Qi Y, Katovich MJ, Li Q, Sriramula S, Francis J, Sumners C, Raizada MK. Brain microglial cytokines in neurogenic hypertension. Hypertension. 2010 Aug;56(2):297-303. PMID: 20547972.

 13.    Cao W, Shah HP, Glushakov AV, Mecca AP, Shi P, Sumners C, Seubert CN, Martynyuk AE. Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. Br J Pharmacol. 2009 Dec;158(8):2005-13. PMID:20050189.

 14.    Jiang N, Shi P, Li H, Lu S, Braseth L, Cuadra AE, Raizada MK, Sumners C. Phosphate-activated glutaminase-containing neurons in the rat paraventricular nucleus express angiotensin type 1 receptors. Hypertension. 2009 Oct;54(4):845-51. PMID: 19667250.

 15.    Li H, Gao Y, Qi Y, Katovich MJ, Jiang N, Braseth LN, Scheuer DA, Shi P, Sumners C. Macrophage migration inhibitory factor in hypothalamic paraventricular nucleus neurons decreases blood pressure in spontaneously hypertensive rats. FASEB J. 2008 Sep;22(9):3175-85. PMID: 18535252.

 16.    Shi P, Martinez MA, Calderon AS, Chen Q, Cunningham JT, Toney GM. Intra-carotid hyperosmotic stimulation increases Fos staining in forebrain organum vasculosum laminae terminalis neurones that project to the hypothalamic paraventricular nucleus. J Physiol. 2008 Nov 1;586(Pt 21):5231-45. PMID: 18755745.

 17.    Shi P, Stocker SD, Toney GM. Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality. Am J Physiol Regul Integr Comp Physiol. 2007 Dec; 293(6):R2279-89. PMID: 17898124.

 

 

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