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赵永超

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赵永超,博士,浙江大学转化医学研究院研究员,浙江大学医学院附属第一医院卫生部多器官联合移植研究重点实验室研究员、博士生导师。长期致力于肿瘤发生的分子机制研究,在肿瘤细胞信号调控、肿瘤发生和发展的分子机理以及抗肿瘤药物作用机制等方面积累了丰富的理论和研究经验。迄今为止,在国际权威刊物上发表SCI论文32篇,包括Molecular CellDevelopmental CelleLife等一作或共同一作16篇,影响因子总和达209,作为课题负责人主持国家重点研发计划“蛋白质机器与生命过程调控”重点专项1项、作为项目负责人主持国家自然科学基金面上项目2项、浙江省自然科学基金杰青项目、浙江大学多学科交叉种子基金和Susan G. Komen for the Cure基金各1.
教育经历
  2002/9 - 2008/1,清华大学,生物学,博士
  1998/9 - 2002/7,厦门大学,生物科学,学士
工作经历
  2015/1 - 至今,浙江大学,附属第一医院,研究员
  2015/1 - 至今,浙江大学,转化医学研究院,研究员
2008/7 - 2014/12,美国密歇根大学,放射肿瘤系,博士后
研究领域
  1. mTOR信号通路抑制因子DEPTOR在肿瘤发生中的生理功能;
2. Cullin-RING LigaseCRL E3 泛素连接酶在肿瘤发生中的调节功能;
3. Neddylation信号通路在肿瘤发生中的调节作用。
代表论文
  1. Wang J, Cui D, Gu S, Chen X, Bi Y, Xiong X, Zhao Y#. Autophagy regulates apoptosis by targeting NOXA for degradation. BBA Molecular Cell Research. 2018, 1865(8):1105-1113. (IF=4.521)
  2. Chen J, Song W, Du Y, Li Z, Xuan Z, Zhao L, Chen J, Zhao Y, Tuo B, Zheng S, Song P. Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation. Biochemical and Biophysical Research Communications. 2018, 499(3):433-440. (IF=2.466)
  3. Gu S, Cui D, Chen X, Xiong X#, Zhao Y#. PROTACs: An emerging targeting technique for protein degradation in drug discovery. Bioessays. 2018, 40(4):e1700247. (IF=4.441) (Highlight by Advanced Science News)
  4. Zhao Y#, Tan M, Liu X, Xiong X#, Sun Y#. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death & Disease. 2018, 9(2):145. (IF=5.965)
  5. Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications. 2017, 8:14002. (IF=12.124)
  6. Song P, Du Y, Song W, Chen H, Xuan Z, Zhao L, Chen J, Chen J, Guo D, Jin C, Zhao Y, Tuo B, Zheng S. KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma. Journal of Cancer. 2017, 8(9):1568-1578. (IF=2.916)
  7. Cui D, Xiong X, Zhao Y#. Cullin-RING ligases in regulation of autophagy. Cell Division. 2016, 11:8. (IF=3.909)
  8. Zhou X, Tan M, Nyati M, Zhao Y, Wang G, Sun Y. Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2016, 113(21):E2935-44. (IF=9.661)
  9. Klionsky D, et al, Zhao Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016, 12(1):1-222. (IF=8.593)
  10. Zhao Y, Morgan M, Sun Y. Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxidants & Redox Signaling. 2014, 21(17):2383-400. (IF=6.337)
  11. Xiong X*, Zhao Y*, Tang F, Wei D, Wang X, Thomas D, Zheng P, Liu Y, Sun Y. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. 2014, 3:e02236. (Selected by Faculty of 1000 Cell Biology) (IF=7.725) * co-first author
  12. Li H, Sun G, Zhao Y, Thomas D, Greenson J, Zalupski M, Ben-Josef E, Sun Y. DEPTOR has growth suppression activity against pancreatic cancer cells. Oncotarget. 2014, 5(24):12811-9. (IF=5.168)
  13. Zhou W, Xu J, Zhao Y, Sun Y. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget. 2014, 5:6746-55. (IF=5.168)
  14. Li H, Tan M, Jia L, Wei D, Zhao Y, Chen G, Zhao L, Thomas D, Bear D, Sun Y. Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. Journal of Clinical Investigation. 2014, 124: 835-46. (IF=12.784)
  15. Zhao Y, Sun Y. The FBW7-KLF2 axis regulates endothelial functions. Cell Research. 2013, 23:741-3. (IF=15.606)
  16. Zhao Y, Sun Y. Cullin-RING Ligases as attractive anti-cancer targets. Current Pharmaceutical Design. 2013, 19:3215-25. (IF=2.611)
  17. Yang D*, Zhao Y*, Liu J, Sun Y, Jia L. Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. Autophagy. 2012, 8: 1856-8. (IF=8.593) * co-first author
  18. Zhao Y, Xiong X, Jia L, Sun Y. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease. 2012, 3: e386. (IF=5.965)
  19. Zhao Y, Sun Y. CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome? Cell Research. 2012, 22:1224–6. (IF=15.606)
  20. Zhao Y, Sun Y. Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application. Neoplasia. 2012, 14: 360-7. (IF=5.006) (Cover story)
  21. Yang D, Zhao Y, Li A, Wang S, Wang G, Sun Y. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast Cancer Research and Treatment, 2012, 133:189-99. (IF=3.626)
  22. Zhao Y, Xiong X, Sun Y. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell. 2011, 44: 304-16. (IF=14.714) (Research Highlight by Nature Reviews Molecular Cell Biology)
  23. Tan M*, Zhao Y*, Kim S, Liu M, Jia L, Saunders T, Zhu Y, Sun Y. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Developmental Cell. 2011, 21: 1062-76. (IF=9.174) * co-first author
  24. Xiong X, Zhao Y, He HB, Sun Y. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene, 2011, 30: 1798–1811. (IF=7.519)
  25. Tan M, Zhu Y, Kovacev J, Zhao Y, Pan Z, Spitz, D, Sun Y. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells. Free Radical Biology and Medicine, 2010, 49: 976-83. (IF=5.606)
  26. Zhao Y*, Shao W*, Wei H, Qiao J, Lu Y, Sun Y, Mitchelson K, Cheng J, Zhou Y. Development of a novel oligonucleotide array-based transcription factor assay platform for genome-wide active transcription factor profiling in Saccharomyces cerevisiaeJournal of Proteome Research. 2008, 7: 1315-25. (IF=4.268) * co-first author
  27. Yang Q*, Zhao Y*, Xiong Q, Cheng J. Rapid chip-based capillary electrophoretic mobility shift assay with negative pressure injection for the binding study of transcription factor Abf1 in Saccharomyces cerevisiae. Electrophoresis. 2008, 29: 5003-9. (IF=2.744) * co-first author
  28. Qiao J, Shao W, Wei H, Sun Y, Zhao Y, Xing W, Zhang L, Mitchelson K, Cheng J. Novel high-throughput profiling of human transcription factors and its use for systematic pathway mapping. Journal of Proteome Research, 2008, 7: 2769-79. (IF=4.268)
  29. Sun Y, Zhang Y, Zeng L, Wu J, Wei L, Ren A, Shao W, Qiao J, Zhao Y, Zhang L, Mitchelson K, Cheng J. Broad profiling of DNA-binding transcription factor activities improves regulatory network construction in adult mouse tissues. Journal of Proteome Research, 2008, 7: 4455-64. (IF=4.268)
  30. Yin H, Zhao Y, Zhang Y, Zhang H, Xu L, Zou Z, Yang W, Cheng J, Zhou Y. Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent. Biotechnology Letters, 2006, 28:99-105. (IF=1.73)
  31. Yin H, Xu H, Zhao Y, Yang W, Cheng J, Zhou Y. Cyclooxygenase- independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays. Biotechnology Letters, 2006, 28:1263-70. (IF=1.73)
  32. Shao W, Wei H, Qiao J, Zhao Y, Sun Y, Zhou Y, Cheng J. Parallel profiling of active transcription factors using an oligonucleotide array-based transcription factor assay (OATFA). Journal of Proteome Research, 2005, 4:1451-6. (IF=4.268)
招聘启事
  本实验室长期欢迎优秀的本科生、硕士、博士研究生和博士后加盟,请有意者直接与赵永超老师联系
联系方式
电话:0571-86971963
电子信箱:yongchao@zju.edu.cn
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