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史鹏

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教育背景

2002-2007    美国德克萨斯大学圣安东尼奥医学中心(University of Texas Health Science Center at San Antonio)  博士  生理专业

1996-2001    泰山医学院  学士  临床医学

科研经历

2016/04-至今   浙江大学转化医学研究院 浙江大学第二附属医院   研究员

2012/08-2016/04美国西达赛奈医学中心(Cedars Sinai Medical Center)    助理教授

2011/07-2012/07美国佛罗里达大学(University of Florida)          助理教授

2007/12-2011/06美国佛罗里达大学(University of Florida)          博士后

研究兴趣与方向

1. 小胶质细胞(Microglia)介导的神经炎症对心血管的调控机制

2. Microglia活性状态的调控机制;以及其对自主神经活性的调节作用

3. Microglia在神经退行性病变中的作用机制

荣誉及奖励

2009  American Heart Association Postdoctoral Fellowship Award

2011  Physiological Genomics Group/Featured Topic Travel Award

2011  American Heart Association Scientist Development Grant Award

2011  American Heart Association Annual High Blood Pressure Research Conference New Investigator Award

2012  American Physiological Society/Neural Control and Autonomic Regulation Section Postdoctoral and Early Career Research Recognition Award

2018  International Society of Hypertension Travel Award

学术组织任职

International Representative of American Physiological Society Neural Control and Autonomic Regulation Section                                                                     2016-

担任杂志编辑

•  Cellular and Molecular Neurobiology

应邀审稿

•  Hypertension

•  Experimental Physiology

•  Vascular Pharmacology

•  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

•  International Journal of Hypertension

•  Journal of Hypertension

•  British Journal of Pharmacology

•  Journal of Cardiovascular Pharmacology and Therapeutics

•  Journal of Neurology & Neurophysiology

•  PLOS ONE

•  Cytokine

发表文章

编书:

1. Guingab, J.D., Kobeissy, F.H., Ratliff, M., Shi, P, Zhang, Z., Wang, K.K.W. Neurogenomic and neuroproteomic approaches to studying neural injury in "essentials of spinal cord injury."(Eds.. Fehlings,. Vaccaro,. Boakye,. Rossignol,. Ditunno, and. Burns), 2010. Thieme Publishers.

综述:

1. Koronyo-Hamaoui M, Shah K, Koronyo Y, Bernstein E, Giani JF, Janjulia T, Black KL, Shi P, Gonzalez-Villalobos RA, Fuchs S, Shen XZ, Bernstein KE. ACE overexpression in myelonibicytic cells: effect of a mouse model of Alzheimer’s disease. Curr Hypertension Rep. 2014 Jul; 16(7):444. PMID: 24792094.

2. Bernstein KE, Gonzalez-Villalobos RA, Giani JF, Shah K, Bernstein E, Janjulia T, Koronyo Y, Shi P, Koronyo-Hamaoui M, Fuchs S, Shen XZ. Angiotensin converting enzyme over expression in myelocytes enhances immune response. Biological Chemistry, 2014, March, PMID: 24633750.

3. Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell W-LB, Shah KH, Taylor BL, Shi P, Fuchs S, Bernstein KE. Rediscovering ACE: Novel insights into the many roles of the angiotensin-converting enzyme. Mol. Medicine (Berlin), 2013 Oct; 91(10): 1143-1154. PMID: 23686164.

4. de Kloet AD, Krause EG, Shi P, Zubcevic J, Raizada MK and Sumners C. Neuroimmune communication in hypertension and obesity: A new therapeutic angle? Pharmacology & Therapeutics. 2013 Feb; 138(8):428-40. PMID: 23458610.

5.Shi P, Raizada MK, Sumners C. Brain cytokines as neuromodulators in cardiovascular control.Clin Exp Pharmacol Physiol. 2010 Feb; 37(2):e52-7. PMID: 19566837.

研究论文:

1. Li Y, Shen XZ, Li L, Zhao TV, Bernstein KE, Johnson AK, Lyden P, Fang J and Shi P. Brain transforming growth factor bresists hypertension via regulating microglial activation. Stroke. 2017 Sep;48(9):2557-2564.PMID: 28698257.

2. Liu M, Shi P and Sumners C. Direct anti-inflammatory effects of angiotensin-(1-7) on microglia. J Neurochem. 2016 Jan; 136(1):163-71. PMID: 26448556.

3. Shah KH, Shi P*, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE and Shen XZ. Myeloid suppressor cells accumulate and regulate blood pressure in hypertension. Circ. Res. 2015, August; 117(10):858-69. (Editorial: Circ Res. 2015; 117(10):830-1) PMID: 26294657.* co-first author.

4. Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P and Shi P. Microglia participate in neurogenic regulation of hypertension. Hypertension. 2015, April; 66(2):309-16. (Editorial: Hypertension. 2015; 66(2):256-6) PMID: 26056339.

5. , Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK and Sumners C. Direct pro-inflammtory effects of prorenin on microglia. PlosOne. 2014, Oct; 10;9(10):e92937. doi: 10.1371 PMID: 25302502.Shi P

6. Shan Z, Zubcevic J, Shi P, Jun JY, Dong Y, Murca TM, Lamont GJ, Cuadra A, Yuan W, Qi Y, Li Q, Paton JF, Katovich MJ, Sumners C and Raizada MK. Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat. Hypertension. 2013, June; 61(6):1328-33. PMID: 23547238.

7. Jiang N, Shi P, Desland F, Kitchen-Pareja MC and Sumners C. Interleukin-10 inhibits angiotensin II-induced decreases in neuronal potassium current. Am J Physiol Cell Physiol. 2013, April; 304(8):C801-7. PMID: 23426971.

8. . PMID: 23319541.Zubcevic J, Jun JY, Lamont G, Murça TM, Shi P, Yuan W, Lin F, Carvajal JM, Li Q, Sumners C, Raizada MK, Shan Z. Nucleus of the solitary tract (Pro)renin receptor-mediated antihypertensive effect involved nuclear factor-κB-cytokine signaling in the spontaneously hypertensive rat. Hypertension. 2013, March; 61(3):622-7

9. Macrophage migration inhibitory factor in the paraventricular nucleus plays a major role in the sympathoexcitatory response to salt. Hypertension. 2010 Nov;56(5):956-63. PMID: 20937969.Colombari E, Colombari DS, Li H, Shi P, Dong Y, Jiang N, Raizada MK, Sumners C, Murphy D, Paton JF.

10. Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. Amino Acids. 2011 Apr;40(4):1151-8. PMID: 20839013.Cao W, Glushakov A, Shah HP, Mecca AP, Sumners C, Shi P, Seubert CN, Martynyuk AE.

11. Involvement of the brain (pro)renin receptor in cardiovascular homeostasis. Circ Res. 2010 Oct;107(7):934-8. PMID: 20689062. *co-first author.Shan Z*, Shi P*, Cuadra AE, Dong Y, Lamont GJ, Li Q, Seth DM, Navar LG, Katovich MJ, Sumners C, Raizada MK.

12. P, Diez-Freire C, Jun JY, Qi Y, Katovich MJ, Li Q, Sriramula S, Francis J, Sumners C, Raizada MK. Brain microglial cytokines in neurogenic hypertension. Hypertension. 2010 Aug;56(2):297-303. PMID: 20547972.Shi

13. Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. Br J Pharmacol. 2009 Dec;158(8):2005-13. PMID:20050189.Cao W, Shah HP, Glushakov AV, Mecca AP, Shi P, Sumners C, Seubert CN, Martynyuk AE.

14. Phosphate-activated glutaminase-containing neurons in the rat paraventricular nucleus express angiotensin type 1 receptors. Hypertension. 2009 Oct;54(4):845-51. PMID: 19667250.Jiang N, Shi P, Li H, Lu S, Braseth L, Cuadra AE, Raizada MK, Sumners C.

15. Macrophage migration inhibitory factor in hypothalamic paraventricular nucleus neurons decreases blood pressure in spontaneously hypertensive rats. FASEB J. 2008 Sep;22(9):3175-85. PMID: 18535252.Li H, Gao Y, Qi Y, Katovich MJ, Jiang N, Braseth LN, Scheuer DA, Shi P, Sumners C.

16. P, Martinez MA, Calderon AS, Chen Q, Cunningham JT, Toney GM. Intra-carotid hyperosmotic stimulation increases Fos staining in forebrain organum vasculosum laminae terminalis neurones that project to the hypothalamic paraventricular nucleus. J Physiol. 2008 Nov 1;586(Pt 21):5231-45. PMID: 18755745.Shi

17. P, Stocker SD, Toney GM. Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality. Am J Physiol Regul Integr Comp Physiol. 2007 Dec; 293(6):R2279-89. PMID: 17898124.Shi



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