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梁平

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   梁平,博士
   教授、博士生导师
   浙江大学转化医学研究院
   浙江大学医学院附属第一医院
   地址:浙江省杭州市凯旋路268
         浙江大学华家池校区中心大楼北楼404
   邮编:310029
      电话:0751-86971872
   电子邮箱:pingliang@zju.edu.cn

教育背景及工作经历

2014.04-至今     浙江大学医学院转化医学研究院及附属第一医院,教授

2011.05-2014.04    美国斯坦福大学,干细胞与心血管疾病,博士后

2010.09-2011.04    百泰生物药业有限公司,医学研发部,项目经理

2005.09-2010.07    北京大学,神经生物学,博士(硕博连读)

2008.01-2009.01    美国加州大学戴维斯分校,生理与膜生物学,访问学者

2000.09-2005.07    中国医科大学,临床医学,本科 

主要研究方向

1) 人多能干细胞(人胚胎干细胞 hESC 和人诱导多能干细胞 hiPSC)向心血管细胞(心肌细胞和内皮细胞)的定向分化

2) 基于hiPSC技术的心血管疾病模型的建立

3) 基于hiPSC来源的心肌细胞和内皮细胞的心血管疾病分子机制的研究

4) 基于病人特异的hiPSC来源的心肌细胞和内皮细胞的药物研发和筛选

5) 基于hESChiPSC来源的心肌细胞的心脏电生理与药理学研究 

发表文章

1) Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, Almeida PE, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Science Translational Medicine 2014; 6 (255): 255ra130

2) Sharma A, Marceau CD, Hamaguchi R, Burridge P, Rajarajan K, Churko J, Wu H, Sallam K, Matsa E, Sturzu A, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circulation Research 2014; 115 (6): 55666

3) Wang Y*, Liang P*,Lan F*, Wu H*, Lisowski L, Gu M, Hu S, Kay M, Urnov F, Shinnawi R, Gold J, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates Long QT phenotype for drug testing. JACC 2014; 64(5): 451-9*并列第一作者

4) Sanchez VF, Lee AS, Hu S, Abilez OJ, Liang P, Lan F, Huber B, Ong S, Hong W, Huang M, Wu JC. Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. JACC 2014; 64(5):436-48

5) Liang P, Du J. Human induced pluripotent stem cell for modeling cardiovascular diseases. Regenerative Medicine Research 2014, 2-

6) Navarrete EG*, Liang P*, Lan F*, Sanchez-Freire V, Simmons CS, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Beygui RE, Bers DM, Wu JC. Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 2013; 128: S3-S13*并列第一作者)

7) Tang Y, Liang P, Zhou J, Lu Y, Lei L, Bian X, and Wang K. Auxiliary KChIP4a suppresses A-type K+ current through ER retention and promoting closed-state inactivation of Kv4 channels. Journal of Biology Chemistry 2013; 288(21):14727-41

8) Liang P*, Lan F*, Lee AS*, Gong T, Sanchez VF, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell derived cardiomyocytes reveals disease specific patterns of cardiotoxicity. Circulation 2013; 127(16): 1677-1691(由Dan RodenCharles Hong 配发评论)(2013年度基础研究领域最佳论文)(*并列第一作者)

9) Lan F*, Lee AS*, Liang P*, Sanchez VF, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell 2013; 12 (1): 101-13Faculty 1000 推荐必读文章)(*并列第一作者)

10) Wang Y, Zhang W, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, Almeida PE, Won J, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circulation Research 2012; 111 (12): 1494-503(封面文章)(由G Courties M Nahrendorf 配发评论)

11) Ebert AD, Liang P, Wu JC.Induced pluripotent stem cells as a disease modeling and drug screening platform.  Journal of Cardiovascular Pharmacology 2012; 60 (4): 408-16

12) Liang P, Chen H, Cui Y, Wang K. Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a. Biophysical Journal 2010; 98 (12): 286776

13) Zhang Y*, Su P*, Liang P, Liu T, Liu X, Liu X, Zhang B, Han T, Zhu Y, Yin D, Li J, Zhou Z, Wang K, Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. Journal of Neuroscience 2010; 30 (22): 7575-86*并列第一作者

14) Liang P*, Wang H*, Chen H*, Cui Y, Gu L, Chai J, Wang K. Structural insights into KChIP4a modulation of Kv4.3 inactivation. Journal of Biology Chemistry 2009; 284 (8): 4960-4967*并列第一作者

15) Cui Y, Liang P, Wang K. Enhanced trafficking of tetrameric Kv4.3 channels by KChIP1 clamping. Neurochemical Research 2008; 33 (10): 2078-84

获得专利

中国国家知识产权局专利(SIPO) 200810102862.X (public #公开号CN101250214):王克威、柴继杰、王华翌、梁平、陈颢、崔媛媛Structural and functional residues for KChIP4 and Kv4 interaction”;“辅助亚基KChIP4Kv4钾离子通道相互作用的结构和功能位点的应用”。

受邀报告

1) 2015University of Alberta与浙江大学联合论坛,2015630日,杭州,受邀报告。题目Providing human model of cardiac arrhythmia using iPSCs 

2) 2015年浙江大学离子通道论坛,2015624日,杭州,受邀报告。题目Providing human model of cardiac arrhythmia using iPSCs 

3) 2015年自身免疫性肾病论坛,201544日,北京,北京大学第一医院,受邀报告。题目:Cardiac iPSC for disease modeling and drug screening 

4) 2014年度浙江大学基础医学学术年会,2015116日,杭州,专题报告。题目:Providing human model of cardiac arrhythmia using iPSCs 

5) 浙江大学医学院附属儿童医院学术报告,2014123日,杭州。题目: The use of iPSCs for disease modeling and drug discovery 

6) 干细胞与再生医学论坛,2014114日,杭州,大会报告。题目:应用iPSC技术进行心血管疾病模型建立和药物筛选

7) 中科院健康所报告,20141024日,上海。题目:Cardiac iPSC for disease modeling and drug screening 

8) 中华医学会第十六次心血管大会(CSC2014),20149月,杭州,大会报告。题目Cardiac iPSC for disease modeling and drug screening 

9) Keystone 论坛(Keystone Symposia: Cardiac Remodeling, Signaling, Matrix and Heart Function), 20139月,UtahUSA,大会报告。题目:Drug screening using a library of human induced pluripotent stem cell derived cardiomyocytes reveals disease specific patterns of cardiotoxicity 

奖励和荣誉

1) 浙江省杰出青年基金获得者2014 

2) 中组部第十一批青年千人计划入选者(2014

3) Circulation Best Paper Award in Basic Science2013 

4) 教育部自然科学奖二等奖(2010

5) 北京大学创新奖学金(2009

6) 北京大学优秀研究生(2008

7) 教育部留学基金委公派留学奖学金(2008

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