当前位置 : 首页 > 师资队伍 > 教授

谢安勇

编辑:admin 时间:2014年05月13日 访问次数:6003

谢安勇简历

浙江大学转化医学研究院及浙江大学医学院附属邵逸夫医院,研究员、博士生导师浙江杭州凯旋路268号浙江大学华家池校区中心北楼604

邮编:310029
电子邮件:anyongxie@zju.edu.cn

研究方向

1. 肿瘤基因组不稳定性及肿瘤靶向药物研发

2.  CRISPR基因编辑技术改良与应用

3.  肝癌发生机制及临床应用研究

教育经历

1996/8 - 2002/7  美国University of Missouri at Columbia,生物化学,博士,

1999/9 - 2001/7  美国University of Missouri at Columbia,工商管理,硕士

1992/9 - 1995/7  中国科学院植物研究所,分子生物学,硕士

1988/9 - 1992/7  北京大学,植物生理学,学士

研究工作经历

2014/2 - 至今   浙江大学转化医学研究院及附属邵逸夫医院,教授

2008/4 - 2014/2   哈佛医学院,讲师

2002/09–2008/04  哈佛医学院/贝斯以色列女执事医疗中心,博士后,

1995/7 - 2002/8   中国科学院植物研究所,植物分子生物学,助理研究员  

奖励

1.  浙江省千人,2014

2.  Margaret Cheng ScholarshipUniversity of Missouri-Columbia1996年

3. 中国科学院院长奖学金优秀奖,1995年 

专业协会成员

1. 浙江省医学会肿瘤学分会肿瘤精准医学学组副组长(2015-至今)

2. 中国细胞生物学会会员(2014-至今)

在研项目基金

2016-2018  浙江省重点研发计划,《肝癌个性化治疗模式研究》

2015-2018  国家自然科学基金面上项目,《抗癌药物PARP抑制剂获得性耐药的进化研究》

2015-2017  浙江大学转化医学研究院种子基金,《肝癌循环肿瘤DNA富集、检测微流控芯片研发》

2015-2017  浙江省新生儿疾病诊治重点实验室开放基金,《小儿毛细血管扩张性共济失调症神经元退化的分子机制研究》

杂志评审人

2014-至今  Nature Medicine, Nature Cell Biology, Nature Communications, PLOS Genetics, Nucleic Acid Research

2013-至今  Mutation Research

2008-至今  Molecular and Cellular Biology

专利申请

谢安勇,郭涛,冯依力:一种CRISPR/Cas9工作效率快速测试系统及其应用 

论著(期刊论文)

研究论文:

1. Liu J, Li J, Fu W, Tang J, Feng X, Chen J, Liang Y, Jin R, Xie A, Cai X.Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation. Drug Des Devel Ther2015;9:5655-67.

2. Liu X-S, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.Nat Commun, 2015; 6:8325.

3. Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end joining DNA repair. Mol Cell, 201557: 648–661.

4. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.Cancer Discov, 2014; 4:1430-1447.

5. Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R. BRCA1 and CtIP suppress long tract gene conversion between sister chromatids. Nat Commun, 20134:2404.

6. Rass E, Chandramouly G, Zha S, Alt FW, Xie A*. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem, 2013288:7086-7095. (*, Corresponding author)

7. Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One, 20127:e49211.

8. Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC. Nek4 regulates entry into replicative senescence and the response to DNA-damage in human fibroblasts. Mol Cell Biol, 201232: 3963-3977.

9. Hu Y, Scully R, Sobhian B, Xie A, Shestokova E, Livingston DM. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev 2011; 25:685-700.

10. Xie A, Odate S, Chandramouly G, Scully R. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle 2010; 9: 3602-3610. (Highlighted in News and Views in Cell Cycle, 2010; 9:3845).

11. Xie A*, Kwok A, Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 2009; 16:814-818 (*, Co-corresponding authorship). (Highlighted in News and Views in Nat Struct Mol Biol 2009; 16:798-800).

12. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated factors MDC1 and 53BP1 in mammalian double strand break repair. Mol Cell 2007; 28:1045-1057. (Evaluated and recommended by Faculty of 1000).

13. Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C.Mol Cell Biol 2006; 26:8075-8086.

14. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R. Control of sister chromatid recombination by histone H2AX. Mol Cell 2004; 16:1017-1025.

15. Xie A-Y and Folk WR. Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.J Virol 2002; 76:11809-11818.

16. Xie A-Y, Bermudez VP, Folk WR. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: Acetylation of large T antigen.Mol Cell Biol 2002; 22:7907-7918.

17. Berjanskii MV, Riley MI, Xie A, Semenchenko V, Folk WR, Van Doren, SR. NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens. J Biol Chem 2000; 275:36094-36103.

18. Yong W-D, Liang T-B, Xie A-Y, Li C, Song Y-R. PhbB, phbC gene expression in E. coli and their transformation and identification in potato.Acta Botanica Sinica 1998; 40:615-621.

19. Xie A-Y, Cui X-J, Song Y-R. Cloning and sequencing of Alcaligenes eutrophus H16 phbB and phbC genes and construction of their plant expression vectors.Acta Botanica Sinica 1995; 37:581-588.

综述:

1. Scully R and Xie A. Double strand break repair functions of histone H2AX. Mutat Res2013750: 5-14 (peer reviewed).

2. Xie A and Scully R. Hijacking the DNA damage response to enhance viral replication: γ-Herpesvirus 68 orf36 phosphorylates histone H2AX. Mol Cell 2007; 27:178-179.

3. Scully R and Xie A. In my end is my beginning: control of end resection and DSBR pathway “choice” by cyclin-dependent kinases.Oncogene 2005; 24:2871-2876.

4. Scully R and Xie A. BRCA1 and BRCA2 in breast cancer predisposition and recombination control.J Mammary Gland Biol Neoplasia 2004; 9:237-246.

5. Scully R, Xie A, Nagaraju G.Molecular functions of BRCA1 in the DNA damage response.Cancer Biol Ther 2004; 3:521-527.

6. Song Y-R and Xie A-Y.Biosynthesis of ethylene and molecular regulation of fruit maturation.Acta Botanica Sinica 1994; 36 (SUPPL.):1-13.

7. Xie A-Y and Song Y-R. Applications of biotechnology in producing biodegradable plastic PHB.Chinese Bulletin of Botany 1994; 11:21-25. 

上一篇:魏文毅
下一篇:徐以兵