当前位置 : 首页 > 师资队伍 > 教授

谢安勇

编辑:admin 时间:2014年05月13日 访问次数:7947

谢安勇 简历
浙江大学转化医学研究院,浙江大学医学院附属邵逸夫医院,教授、博导
 
研究方向
1.  1. 肿瘤基因组不稳定性及肿瘤靶向药物研发
2.  2. CRISPR基因编辑技术改良与应用
3.  3. 肝癌发生机制及临床应用
 
教育经历(从大学本科开始,按时间倒排序)
1996/8 - 2002/7,美国University of Missouri at Columbia,生物化学,博士,
 导师:William Folk
1999/9 - 2001/7,美国University of Missouri at Columbia,工商管理,硕士
1992/9 - 1995/7,中国科学院植物研究所,分子生物学,硕士,导师:宋艳茹
   1988/9 - 1992/7,北京大学,植物生理学,学士
 
研究工作经历(按时间倒排序)
2014/2 - 至今,浙江大学转化医学研究院及附属邵逸夫医院,研究员
2008/4 - 2014/2,哈佛医学院,讲师
2002/09–2008/04,哈佛医学院/贝斯以色列女执事医疗中心,博士后,导师:Ralph Scully
1995/7 - 2002/8,中国科学院植物研究所,植物分子生物学,助理研究员
 
奖励
1.  1. 浙江省千人,2014年
2.  2.  Margaret Cheng Scholarship,University of Missouri-Columbia,1996年
3.  3. 中国科学院院长奖学金优秀奖,1995年
 
 
专业协会成员
1.    浙江省医学会肿瘤学分会肿瘤精准医学学组副组长(2015-至今)
2.    中国细胞生物学会会员(2014-至今)
3.     Dana Farber/Harvard Cancer Center Breast Cancer Research Program成员 2012-2014
4.          International Association for Biological and Medical Research (IABMR)成员(2007
5.          American Association for Cancer Research (AACR) 成员(2007
6.          Society for Experimental Biology and Medicine (SEBM) 成员(2006
 
主持科研项目情况
2017-2020,Z17C060003,浙江省自然科学基金重点项目,《DNA 双链断裂修复因子ATM 在CRISPR 基因编辑调节中的作用机制研究》,¥40万,主持
2017-2020,31671385,国家自然科学基金面上项目,《CRISPR基因编辑技术的DNA双链断裂修复机制研究》,¥74.4万,主持
2016/7-2019/6,81661128008,2016年度国家自然科学基金委员会(NSFC)与加拿大魁北克研究基金会医学部(FRQS)癌症合作研究项目,《靶向DNA损伤应答与修复的癌症个体化治疗研究》,¥300万,参与
2016-2018,2015C03047,浙江省重点研发计划,《肝癌个性化治疗模式研究》,¥100万,主持
2015-2018,81472755,国家自然科学基金面上项目,《抗癌药物PARP抑制剂获得性耐药的进化研究》,¥72万,主持
2015-2017, 浙江大学转化医学研究院种子基金,《肝癌循环肿瘤DNA富集、检测微流控芯片研发》,¥20万,主持
2015-2017,2015-ZJKL-ND-001,浙江省新生儿疾病诊治重点实验室开放基金,《小儿毛细血管扩张性共济失调症神经元退化的分子机制研究》,¥5万,主持
2014-2016,浙江大学及浙江大学医学院附属邵逸夫医院启动经费,¥200万,主持
 
评审人
2017,浙江省“万人计划”杰出人才、科技创新领军人才和科技创业领军人才评审人
2015-至今,国家自然科学基金评审人和浙江省自然科学基金评审人
2008-至今,国际顶级学术杂志Nature Medicine, Nature Cell Biology, Nature Communications, PLOS Genetics, Nucleic Acids ResearchOncogeneActa Biochim Biophys SinMutation ResearchMolecular and Cellular BiologyScientific Reports论文评审人                     
 
专利申请
   谢安勇,郭涛,冯依力:一种CRISPR/Cas9工作效率快速测试系统及其应用;
   专利申请号:201610073847.1
 
论著(期刊论文;*: 通讯作者
1.  1. Xie X, Hu H, Tong X, Li L, Liu X, Chen M, Yuan H, Xie X, Li Q, Zhang Y, Ouyang H, Wei M, Huang J, Liu P, Gan W, Liu Y, Xie A, Kuai X, Chirn GW, Zhou H, Zeng R, Hu R, Qin J, Meng FL, Wei W, Ji H, Gao D*. The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168. Nat Cell Biol 2018; 20: 320-331.
2.     2.  Han J, Ruan C, Huen M, Wang J, Xie A, Fu C, Liu T, Huang J*. BRCA2 antagonizes 53BP1/RIF1/Artemis-dependent classical and alternative nonhomologous end-joining to prevent gross genomic instability. Nat Commun2017; 8: 1470. (影响因子: 11.470)
3.    3. Feng Y-L, Xiang J-F, Liu S-C, Guo T, Yan G-F, Feng Y, Kong N, Li H-D, Huang Y, Lin H,
Cai X-J*, Xie A-Y*. H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic Acids Res, 2017; 45: 10614-10633. (影响因子: 10.162)
4.    4. Guirouilh-Barbat J, Gelot C, Xie A, Dardillac E, Scully R, Lopez BS*. 53BP1 protects against ctip-dependent capture of ectopic chromosomal sequences at the junction of distant double strand breaks. PLOS Genet, 2016; 12:e1006230. (影响因子: 6.668)
5.    5. Tang J-C, Feng Y-L, Guo T, Xie A-Y*, Cai X-J*. Circulating tumor DNA in hepatocellular carcinoma: trends and challenges. Cell Biosci, 2016; 6:32. (影响因子: 2.089)
6.    6. Feng Y-LXiang J-FKong NCai X-J*Xie A-Y*. Buried territories: heterochromatic response to DNA double strand breaks. Acta Biochim Biophys Sin, 2016; 48:594-602 (受邀综述) (影响因子: 2.089)
7.    7. Chen J, Ji T, Zhao J, Li G, Zhang J, Jin R, Liu J, Liu X, Liang X, Huang D, Xie A, Lin H*, Cang Y*, Cai X*. Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint. Oncotarget, 2016. 7:41274-41284. (影响因子: 5.008)
8.    8.  Liu J, Li J, Fu W, Tang J, Feng X, Chen J, Liang Y, Jin R, Xie A, Cai X*. Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation. Drug Des Devel Ther2015; 9:5655-67. (影响因子: 3.028)
9.    9.  Liu X-S, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R*, Lunardi A*, Pandolfi PP*. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun, 2015; 6:8325. (影响因子: 11.470)
10. 10. Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W*. Akt-mediated phosphorylation of XLF impairs non-homologous end joining DNA repair. Mol Cell, 201557: 648–661. (影响因子: 14.018)
11.  11. Tang JC, Xie AY, Cai XJ. Diverse functions of fibulin-5 in tumor. Mol Biol, 2014, 48: 761-766
12.  12. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM*. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov, 2014; 4:1430-1447. (影响因子: 19.453)
13.  13.  Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R*. BRCA1 and CtIP suppress long tract gene conversion between sister chromatids. Nat Commun, 20134:2404. (影响因子: 11.470)
14.  14. Rass E, Chandramouly G, Zha S, Alt FW, Xie A*. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem, 2013288:7086-7095. (影响因子: 4.573)
15.  15. Scully R* and Xie A. Double strand break repair functions of histone H2AX. Mutat Res2013750: 5-14 (peer reviewed). (影响因子: 3.680)
16.  16.  Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R*. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One, 20127:e49211. (影响因子: 3.234)
17.  17.  Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC*. Nek4 regulates entry into replicative senescence and the response to DNA-damage in human fibroblasts. Mol Cell Biol, 201232: 3963-3977. (影响因子: 4.777)
18.  18. Hu Y, Scully R, Sobhian B, Xie A, Shestokova E, Livingston DM*. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev 2011; 25:685-700. (影响因子: 10.798)
19.  19.  Xie A, Odate S, Chandramouly G, Scully R*. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle 2010; 9: 3602-3610. (Highlighted in News and Views in Cell Cycle, 2010; 9:3845). (影响因子: 4.565)
20.  20. Xie A*, Kwok A, Scully R*. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 2009; 16:814-818 (*, Co-corresponding authorship). (Highlighted in News and Views in Nat Struct Mol Biol 2009; 16:798-800). (影响因子: 13.309)
21.  21. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R*. Distinct roles of chromatin-associated factors MDC1 and 53BP1 in mammalian double strand break repair. Mol Cell 2007; 28:1045-1057. (Evaluated and recommended by Faculty of 1000). (影响因子: 14.018)
22.  22. Xie A and Scully R*. Hijacking the DNA damage response to enhance viral replication: γ-Herpesvirus 68 orf36 phosphorylates histone H2AX. Mol Cell 2007; 27:178-179. (影响因子: 14.018)
23.  23. Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol 2006; 26:8075-8086. (影响因子: 4.777)
24.  24. Scully R* and Xie A. In my end is my beginning: control of end resection and DSBR pathway “choice” by cyclin-dependent kinases. Oncogene 2005; 24:2871-2876. (影响因子: 8.459)
25.  25. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R*. Control of sister chromatid recombination by histone H2AX. Mol Cell 2004; 16:1017-1025. (影响因子: 14.018)
26.  26. Scully R* and Xie A. BRCA1 and BRCA2 in breast cancer predisposition and recombination control. J Mammary Gland Biol Neoplasia 2004; 9:237-246. (影响因子: 4.526)
27.  27. Scully R*, Xie A, Nagaraju G.Molecular functions of BRCA1 in the DNA damage response. Cancer Biol Ther 2004; 3:521-527. (影响因子: 3.072)
28.  28. Xie A-Y and Folk WR*. Inhibition of polyomavirus ori-dependent DNA replication by mSin3B. J Virol 2002; 76:11809-11818. (影响因子: 4.439)
29.  29. Xie A-Y, Bermudez VP, Folk WR*. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: Acetylation of large T antigen. Mol Cell Biol 2002; 22:7907-7918. (影响因子: 4.777)
30.  30. Berjanskii MV, Riley MI, Xie A, Semenchenko V, Folk WR, Van Doren, SR*. NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens.  J Biol Chem 2000; 275:36094-36103. (影响因子: 4.573)
31.  31. Yong W-D, Liang T-B, Xie A-Y, Li C, Song Y-R*. PhbB, phbC gene expression in E. coli and their transformation and identification in potato. Acta Botanica Sinica 1998; 40:615-621.
32.  32. Xie A-Y, Cui X-J, Song Y-R*. Cloning and sequencing of Alcaligenes eutrophus H16 phbB and phbC genes and construction of their plant expression vectors. Acta Botanica Sinica 1995; 37:581-588.
33.  33. Song Y-R* and Xie A-Y. Biosynthesis of ethylene and molecular regulation of fruit maturation. Acta Botanica Sinica 1994; 36 (SUPPL.):1-13.
34.  34. Xie A-Y and Song Y-R*. Applications of biotechnology in producing biodegradable plastic PHB. Chinese Bulletin of Botany 1994; 11:21-25. 


上一篇:魏文毅
下一篇:徐以兵