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孙毅

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教育背景
1986/02-1989/05  美国爱荷华大学,放射生物专业,博士
1982/02-1985/12  浙江医科大学,生物化学专业,硕士
1978/02-1982/12  江西医学院,医疗专业,本科
研究工作经历
2014/01-至今    浙江大学转化医学研究院院长,教授,博士生导师,
               中组部千人计划特聘专家,美国科学促进会会士
2008/09-2013/12  美国密西根大学放射肿瘤生物系终身教授
2006/09-2008/08  美国密西根大学放射肿瘤生物系终身副教授
2003/08-2006/08  美国密西根大学放射肿瘤生物系副教授
2002/02-2003/07  辉瑞(Pfizer)癌症分子科学全球研究部门资深研究员
1995/01-2002/01  帕克戴维斯(Parke-Davis)癌症研究所高级研究员
1992/09-1994/12  美国国立癌症研究所(NCI)高级研究员
1990/01-1992/07  美国国立癌症研究所(NCI)高级博士后
研究领域
1.Cullin-RING ligaseCRL)泛素连接酶在肿瘤发生发展中的作用及机理;
2.蛋白质的 Neddylation 修饰与肿瘤的关系;
3.靶向Neddylation-CRL的小分子抗癌药物的研发。
关键实验技术
1. 条件性转基因小鼠动物模型构建及后续肿瘤形成的分析
2. 检测蛋白泛素化和类泛素化的生化分析
3. 细胞增殖、凋亡、自噬和衰老的细胞生物学检测技术
4. 基因过表达及siRNA沉默的分子生物学技术
5. 组织学,病理学常规技术手段
6. 高通量药物筛选技术
转化潜能
1. 小分子泛素连接酶抑制剂的抗癌作用
2. 小分子类泛素化酶抑制剂的抗癌作用
3. 肿瘤的生物标志物的鉴定--用于早期诊断和预后分析
近期主要论著(共200余篇)
1.   Zhou, W., Xu, J., Tan, M., Zhang, J., Li, H., Li, H., Wei, W.,Sun, Y.: UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F. Mol. Cell,in press.
2.   Zhao, Y., Tan, M., Liu, X., Xiong, X., Sun, Y.: Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death  Dis. 2018 Feb 2;9(2):145.
3.  Zhou, W., Xu, J., Li, H., Xu, M., Chen, Z.J., Wei, W., Pan, Z., and Sun, Y.: Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage. Clinical Cancer Res. 2017, 23:1104-1116.
4.   Xu, J., Zhou, W., Yang, F., Chen, G., Li, H., Zhao, Y., Liu, P., Li, H., Tan, M., Xiong, X., and Sun, Y.: The βTrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a novel tumor suppressor. Nature Communs, 2017 Jan 16;8:14002. doi: 10.1038/ncomms14002.
5.  Zhou, H., Lu, J., Liu L., Bernard, D., Yang, C.-Y., Chinnaswamy, K., Layton, S., Jeanne Stuckey, J., Yu, Q., Zhou, W., Pan, Z., Sun, Y., and Wang, S.:  A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.Nat Communs. 2017 Oct 27;8(1):1150. doi: 10.1038/s41467-017-01243-7.
6.   Zhang, Q., Karnak, D., Tan, M., Lawrence, T.S., Morgan, M.A., Sun, Y.: FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4. Mol. Cell, 2016, 61: 419-433..
7.   Wu, K., Chong, R. A., Yu, Q., Bai, J., Spratt, D. E.,  Ching, K., Lee, C.,  Miao, H., Zheng, N., Shaw, G. S.,  Sun, Y., Felsenfeld, D. P., Sanchez, R., Zheng, J.-N., and Pan., Z.-Q.: Suramin inhibits cullin-RING E3 ubiquitin ligases. Proc. Natl. Acad. Sci. USA., 2016, 113 (14) E2011-E2018.
8.  Zhou, X. Tan, M., Nyati, M., Zhao, Y., Wang, G.X., and Sun, Y.: Blockage of neddylation modification stimulates tumor sphere formation in vitro, and stem cell differentiation and wound healing in vivoProc. Natl. Acad. Sci. USA.2016 May 24;113(21):E2935-2944. doi: 10.1073/pnas.1522367113.
9.   Lan, H., Tang, Z., Jin, H., and Sun, Y.: Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells. Sci Rep. 2016 Apr 11; 6:24218. doi: 10.1038/ srep24218. PMID: 27063292.
10. Kuang, P., Tan, M., Zhang, Q., and Sun, Y.: SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation.  Sci Rep, 2016, 6:37441. DOI: 10.1038/srep37441.
11.  Tan, M., Xu, J., Feng, F., and Sun, Y.: Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis. Mol. Cancer, Mol Cancer. 2016 Dec 12;15(1):81.PMID:27955654.
12.  Xie, C. M., Wei, D., Zhao, L., Marchetto, S., Mei, L., Borg,J.-P.,and Sun, Y.:Erbin is a novel substrate of Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J. Cell Biol, 2015, 209: 721-737.
13.  Xiong, X.*, Zhao, Y.*, Tang, F., Thomas, D., Wang, X., Liu, Y., Zheng, P., and Sun, Y.: Ribosomal protein S27-like is a physiological inhibitor of p53 that paradoxically suppresses tumorigenesis.eLife. Aug 21: e02236. doi: 10.7554/eLife.02236.
14.  Li, H.*, Tan, M.*, Jia, L., Wei, D., Zhao, Y., Chen, G., Xu, J., Zhao, L., Thomas, D., Beer, D.G., and Sun, Y.: Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. J. Clin. Invest. 2014 Feb 3;124(2):835-46. doi: 10.1172/JCI70297.
15.   Zhou, W., Wei, W. and Sun, Y.: Genetically engineered mouse models for functional studies of SCF E3 ubiquitin ligases. Cell Res., 23: 599-619, 2013.
16.  Wei, D., Li, H., Yu, J., Sebolt, J. T., Zhao, L., Lawrence, T. S., Smith, P. G., Morgan, M. A., and Sun, Y.: Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. Cancer Res., 2012, 72: 282-293.
17. Tan, M*., Zhao, Y*., Kim, S., Liu, M., Jia, L., Saunders, T., Zhu, Y., and Sun, Y.: SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Dev. Cell, 21:1062-76, 2011.
18.  Zhao, Y., Xiong, X., and Sun, Y.: DEPTOR, an mTOR inhibitor, is a physiological substrate of SCFβTrCP E3 ubiquitin ligase and regulates survival and autophagy. Mol. Cell, 44: 304-316, 2011.
 
Email: yisun@zju.edu.cn
 

 

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