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李学坤

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李学坤,博士,教授

工作单位:浙江大学转化医学研究院           

地址浙江省杭州市江干区凯旋路268号,浙江大学华家池校区中心大楼北楼440房间

电子邮箱xuekun_li@zju.edu.cn

教育经历:

2000/09-2003/06  协和医科大学    博士

研究经历

2014/12 -         浙江大学医学院/浙江大学儿童医院,教授

2013/06-2014/11   浙江大学生命科学学院,教授

2012/05-2013/06   美国Emory大学人类遗传学系,研究助理教授

2010/10- 2012/04   美国Emory大学人类遗传学系,Instructor

2008/12- 2010/09   美国Emory大学人类遗传学系,博士后

2006/12- 2008/11   美国新墨西哥州大学神经科学系,博士后

2004/05- 2006/11   美国Emory大学细胞生物学系,博士后

荣誉和奖励:

2013         浙江省千人计划

2012         Autism Speaks独立研究奖

2009         FRAXA 研究基金会博士后研究奖

2008         6届国际干细胞年会(ISSCR)旅游奖,费城,美国

2008         Autism Speaks基金会博士后研究奖

 
主要研究方向:
1. 表观遗传学修饰对神经发生和成体神经干细胞功能的调控作用
2. 表观遗传学修饰在神经系统疾病中的作用

发表论文:

1.     Li X#, Yao B, Chen L, Kang Y, Li Y, Cheng Y, Li L, Lin L, Wang Z, Wang M, Pan F, Dai Q, Zhang W, Wu H, Shu Q, Qin Z, He C, Xu M, Jin P#. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nature Communications 8: 15903(2017). (# co-correspondence).
 
2.     Li L, Zang L, Zhang F, Chen J, Shen H, Shu L, Liang F, Feng C, Chen D, Tao H, Xu T, Li Z, Kang Y, Wu H, Tang L, Zhang P, Jin P#, Shu Q#, Li X#.Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.Hum Mol Genet 26(13): 2398-2411(2017). (# co-correspondence).
 
3.     Li Y, Park C, Vellón L, Li X. iPSCs: From Bench to Clinical Bed. Stem Cells Int. 8367587(2016).
 
4.     Liqi Shu, Wenjia Sun, Liping Li, Zihui Xu, Li Lin, Pei Xie, Hui Shen, Luoxiu Huang, Qi Xu, Peng Jin, Xuekun Li.Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s disease. BMC Genomics 17(1):381-391(2016).
 
5.     Zhang P, Zhang L, Zhu L, Chen F, Zhou S, Tian T, Zhang Y, Jiang X, Li X, Zhang C, Xu L, Huang F.The change tendency of PI3K/Akt pathway after spinal cord injury. Am J Transl Res 15;7(11):2223-3222(2015).
 
6.     Li, H., Zhong, X., Chau, KF., Santistevan, NJ.,  Guo,WX., Kong, GY.,  Li, X. , Kadakia, M., Masliah,J.Chi,JY.,  Jin, P., Zhang, J., Zhao, XY., Chang, Q. Cell cycle-linked ​MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nature communications 5:5601-5610 (2014)
 
7.     Sun, W*., Zang, L*., Shu, Q., Li., X. From development to diseases: The role of 5hmC in brain. Genomics104:347-351 (2014).
 
8.     Sun, W., Guan, M., and Li, X. 5-hydroxymethylcytosine mediated DNA demethylation in stem cells and development. Stem cells and Dev 23:923-930 (2014).
 
9.     Xu, Z., Poidevin, M., Li, X., Li, Y., Shu, L., Nelson, DL., Li, H., Hales, CM., Gearing, M., Wingo, TS., Jin, P. Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration. Proc Natl Acad Sci USA 110:7778-7783 (2013).
 
10. Wang. T., Wu,H., Li, Y., Szulwach, KE., Lin, L., Li, X., Chen, I., Goldlust, I., Chamberlain, S., Ananiev, G., Mowrey, J., Han, J., Kim, M., Yoon,Y., Rudd, M., Song, C., He, C., Chang, Q., Warren, S., Jin, P. Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nature Cell biology 15:700-711(2013).
 
11. Hong,Y., Chan, CB., Kwon, IS., Li, X., Song, M., Lee, HP., Liu, X., Sompol, P.,  Jin, P., Lee, HG., Yu, SP., Ye, K. (2012) SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci 32:17262-12772.
 
12. Wang, T., Pan, Q., Lin L, Szulwach, KE., Song, CX., He, C., Wu, H., Warren, ST., Jin, P., Duan, R., Li, X. (2012) Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum, Hum Mol Genet21,5500-5510.
 
13. Yu, M., Hon, G., Szulwach, K., Song, C., Zhang, L., Kim, A., Li, X., Dai, Q., Park, B., Min, J., Jin, P., Ren, B., He, C. (2012) Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome. Cell149,1368-1380.
 
14. Xu,Z., Li, X. DNA Methylation in Neurodegenerative Disorders. Curr Tran Geriatr Gerontol1:199–205 (2012).
 
15. Szulwach, K.E*., Li, X*., Li, Y., Song, C.X., Wu, H., Dai, Q., Irier, H., He, C. and Jin, P. (2011) 5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging. Nature Neuroscience 14:1607-1616 (* equal contribution).
 
16. Szulwach, KE., Li, X, Li, Y., Song, CX., Han, JW., Kim, S., Namburi,S., Hermetz, K., Kim, JJ., Rudd, MK., Yoon, YS., Ren, B., He, C., Jin, P. (2011) Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet 7: e1002154.
 
17. Qurash,A., Li, X*., Jin, P*. (2011) Fragile X Mental Retardation Protein and Stem Cells. (* co-corresponding author; Robert B. Denman edited, Springer)
 
18. Song, C.X., Szulwach, K.E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T.J., Zhang, B., Godley, L.A., Hicks, L.M., Lahn, B.T., Jin, P., and He, C. (2011) Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nature Biotechnology 29,68-72.
 
19. Li, X. and Jin, P. (2010) Roles of small regulatory RNAs in determining neuronal identity. Nature Reviews Neurosci 11:329-338.
 
20. Luo, Y., Shan, G., Guo, W., Smrt, R.D., Johnson, E., Li, X., Duan, R., Barkho, B.Z., Li, W., Jin, P., and Zhao, X. (2010) Fragile X mental retardation protein regulates adult neurogenesis. PLoS Genetics 6: e1000898.
 
21. Smrt, RS., Szulwach, KE., Pfeiffer, RL., Li, X., Guo, W., Pathania, M., Luo, Y., Wilson, MC., Bordey, A., Jin, P., and Zhao, X.(2010)MicroRNA miR-137 modulates neuronal maturation through translational regulation of Mind Bomb-1. Stem Cells 28:1060-1070.
 
22. Szulwach, KE*., Li, X*., Smrt, RS., Li, Y., Luo, Y., Lin, L., Santistevan, N., Li, W., Zhao X., and Jin, P. (2010) MeCP2-mediated crosstalk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biology 189:127-141(*equal contribution).
 
23. Li, X., and Jin, P.(2009) Macro role(s) of microRNAs in fragile X syndrome? Neuromolecular Med11:200-207.
 
24. Barkho, B., Munoz., A., Li, X., Li, L., Cunningham, L., and Zhao, X. (2008) Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 mediate the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells 26: 3139-3149.
 
25. Li, X., Tang, X., Jablonska, B., Aguirre, A., Gallo, V., and Luskin, M. (2009) p27KIP1 Regulates Neurogenesis in the Rostral Migratory Stream and Olfactory Bulb of the Postnatal Mouse. J Neurosci 29:2902-2914.
 
26. Szulwach, K., Li, X., Zhao, X, Jin, P. (2009) Epigenetic Regulation of miRNA in Stem Cells. Current Perspective in miRNAs, (Springer).
 
27. Li, X., Barkho. BZ., Luo, Y., Smrt, RD., Santistevan, NJ., Liu, C., Kuwabara, T., Gage, FH., Zhao, X. (2008) Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem 283:27644-27652.
 
28. Allan, A., Liang, X., Luo, Y., Pak, C., Li, X., Szulwach, K., Chen, D., Jin, P., Zhao, X. (2008) The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Hum Mol Genet 17:2047-2057.
 
29. Li, X., Zhao, X. (2008) Epigenetic Regulation of mammalian stem Cells. Stem Cells Dev 17:1043-1052.
 
30. Li, X., Barkho, BZ., Zhao, X. (2008) Neural stem cells and neurogenic niche in the adult brain. Stem Cell Research and Therapeutics edited by Shi Y and Clegg D. Springer   
 
31. Kong, X., Li, X., Cai, Z., Yang, N., Liu, Y., Shu, J., Pan, J., Zuo, P. (2008) Melatonin regulates viability and differentiation of rat midbrain neural stem cells. Cellular and Molecular Neurobiology 28:569-579.
 
32. Tang, X*., Falls, L*., Li, X., Lane, T., and Luskin, MB. (2007) Antigen-Retrieval Procedure for Bromodeoxyuridine Immunolabeling with Concurrent Labeling of Nuclear DNA and Antigens Damaged by HCl Pretreatment. J Neurosci 27:5837-5844.
 
33. Cui, X., Zuo, P., Zhang, Q., Li, X., Hu, Y., Long, J., Packer, L., Liu, J. (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-alpha-lipoic acid. J Neurosci Res83:1584-1590.
 
34. Zhang Q., Huang Y., Li, X., Cui X., Zuo P. and Li J. (2005) GM1 ganglioside prevented the decline of hippocampal neurogenesis associated with D-galactose. Neuroreport 16:1297-1301.
 
35. Zhang Q*., Li, X*., Cui X. and Zuo P. (2005) D-Galactose injured neurogenesis in the hippocampus of adult mice. Neurol Res 27: 552-556.
 
36. Li, X., and Zuo P. (2005) Effects of Aβ25-35 on neurogenesis in the adult mouse subventricular zone and dentate gyrus. Neurol Res 27: 218-222.
 
37. Li, X., Guo A. and Zuo P. (2003) Survival and differentiation of transplanted neural stem cell in the brain of MPTP-induced Parkinson’s disease model mouse. ACTA PHARMACOLOGICA SINICA 24:1192-1198.

 

基金资助:

“Ogt介导的O-GlcNAc糖基化修饰对成年小鼠神经干细胞和学习记忆的调控作用与机制研究

国家自然基金面上项目                                             2016.1-2019.12  

“5-羟甲基胞嘧啶对成体神经干细胞和神经发生的表观遗传学调控研究

人社部回国人员启动基金(优秀类)                     2015.1-2015.12

 “听觉微环路障碍形成的遗传和分子机制

科技部“973”项目子课题(骨干)                               2014.1-2018.12

“5-羟甲基胞嘧啶对成体神经干细胞和神经发生的表观遗传学调控研究

国家自然基金面上项目                                              2014.1-2017.12         

“5-Hydroxymethylcytosine-Mediated Epigenetic Modulation in Autism Spectrum Disorders”

Autism Speaks Foundation                                             2012.1-2013.12

Roles: PI

“Small Molecule Screen using Fragile X Neural Stem Cells”  

Fragile X Research Foundation                                       2009.5-2011.4 

Roles: Postdoctoral Fellow

“MBD1 regulation of anxiety and autism”

Autism Speaks                                                               2008.1-2008.12

Roles: Postdoctoral Fellow

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