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闵军霞

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闵军霞博士、教授/博士生导师 浙江大学转化医学研究院
 
简历2006年美国密苏里哥伦比亚大学生物学博士;2006-2010年哈佛大学医学院医学遗传系博士后;2010-2014年任诺华(Novartis,美国)肿瘤部新药研发团队负责人,主要负责整合分析多种组学大数据发现肿瘤新型分子靶标及CAR-T的优化研究。 2014年,加盟浙江大学并入选浙江省海外高层次“浙江省千人”创新学者及“浙江省特聘专家”。
 
主要研究方向:1. CAR-T的全程优化研究;2. 肿瘤的转化医学研究;3.人类衰老与长寿的转化医学研究。
 
主持及参加项目          
1.  国家自然科学基金面上项目,RNA解旋酶DDX17与p53抑癌基因突变的协同作用及分子机制研究,项目批准号:31570791,2016/01-2019/12,84万元,主持。
2.  国家自然科学基金重大项目(应对老龄社会的基础科学问题研究课题二)“健康老龄化--老年人口健康影响因素及有效干预的基础科学问题研究”项目批准号: 71490732, 2015年1月-2019年12月; 425万;课题组副组长。
3.  国家自然科学基金重大研究计划,肝脏树突状细胞在移植肝区域免疫中的作用及研究机制,项目批准号:91542205,2016/01-2020/12,280万元,课题骨干。
4.  浙江省自然科学基金重点项目,项目批准号:Z15H160009,胃癌中靶向ERBB3 抑癌效应及分子机制研究,2015/01-2018/12,30万元,主持
5.  浙江大学横向课题,人类衰老与长寿的转化医学研究,107万,项目负责人。

发表论文
通讯作者论文
1.     Fang X#, Wei J#, He X#, Lian J#, Han D, An P, Zhou T, Liu S, Wang F*, Min J*. Quantitative association between body mass index and the risk of cancer: A global Meta-analysis of prospective cohort studies. International Journal of Cancer. 2018 Apr 26.
2.     An P, Wang H, Wu Q, Wang J, Xia Z, He X, Wang X, Chen Y, Min J*, Wang F*. Smad7 deficiency decreases iron and haemoglobin through hepcidin up-regulation by multilayer compensatory mechanisms. Journal of Cellular and Molecular Medicine, 2018 Mar 30.
3.     Zhang Y#, Wang X#, Wu Q, Wang H, Zhao L, Wang X, Mu M, Xie E, He X, Shao D, Shang Y, Lai Y, Ginzburg Y, Min J* and Wang F*. Adenine alleviates iron overload by cAMP/PKA mediated hepatic hepcidin in mice. Journal of Cellular Physiology, 2018 Mar 30.
 
4.    Gao H, Zhao L, Wang H, Xie E, Wang X, Wu Q, Yu Y, He X, Ji H, Rink L, Min J, Wang F. Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. PNAS. 2017 Dec 5;114(49):12940-12945. Epub 2017 Nov 2
5.    Wang H, An P, Xie E, Wu Q, Fang X, Gao H, Zhang Z, Li Y, Wang X, Zhang J, Li G, Yang L, Liu W, Min J*, Wang F*. Characterization of Ferroptosis in Murine Models of Hemochromatosis. Hepatology 2017 Aug;66(2):449-465. Epub 2017 May 162017.
6.     HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-overload Murine Models. Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, Zhang H, Wang ZY, Zhou T, Shi Y, Rogers J, Lin H, Min J*, Wang F*. Antioxidants & Redox Signaling. 2017 Nov 7.
7.     Wu Q, Shen Y, Tao Y, Wei J, Wang H, An P, Zhang Z, Gao H, Zhou T, Wang F*, Min J*. Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice. Cell Discovery. 2017 Aug 15; 3:17028. doi: 10.1038/celldisc.2017.28.
8.    Xia Z, Wei J, Li Y, Wang J, Li W, Wang K, Hong X, Zhao L, Chen C, Min J*, Wang F*. Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis. PLOS Genetics. 2017 Jul 10;13(7): e1006892.doi: 10.1371/journal.pgen.1006892.
9.     Wang X#, An P#, Zeng J, Liu X, Wang B, Fang X, Wang F*, Ren G*, Min J*. Serum ferritin in combination with prostate-specific antigen improves predictive accuracy for prostate cancer. Oncotarget 2017. doi:10.18632/oncotarget.14977
10.    Fang X, Wei J, He X, An P, Wang H, Jiang L, Shao D, Liang H, Li Y, Wang F*, Min J*. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. European Journal of Cancer. 2015; 51:2820–2832.
11.     An P, Wang H, Wu Q, Guo X, Wu A, Zhang Z, Zhang D, Xu X, Mao Q, Shen X, Zhang L, Xiong Z, He L, Liu Y, Min J*, Zhou D*, Wang F*. Elevated serum transaminase activities were associated with increased serum levels of iron regulatory hormone hepcidin and hyperferritinemia risk. Scientific Reports. 2015; 5:13106.
12.      Wu Q, Wang H, An P, Tao Y, Deng J, Zhang Z, Shen Y, Min J*, Wang F*. HJV and HFE Play Distinct Roles in Regulating Hepcidin. Antioxidants & Redox Signaling. 2015;22(15):1325-36.
 
第一作者论文
1.     Min J, Fedele G, Zaslavsky A, Reczek E, Guney I, Strochlic D, Bronson RT, Hahn WC, Ryeom S, Loda M and Cichowski K. (2010) An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and NF-kB. Nature Medicine, Mar;16(3):286-94 (Article)

2.     Min J, Mesika A, Sivaguru M, Van Veldhoven PP, Alexander H, Anthony H. Futerman AH and Alexander S. (2007) LASS1 dihydroceramide synthase induced sensitivity to cisplatin is mediated through the activation of p38 MAP kinase and is abrogated by sphingosine kinase 1. Molecular Cancer Research. 5(8):801-12 (Cover article)

3.      Min J., Sridetive P., Hanigan MH., Alexander H. (2006) Sensitive cell viability assay for use in drug screens and for studying the mechanism of action of drugs in Dictyosteliumdiscoideum. Biotechniques, 41(5):591-5. (Featured article)
4.     Min J., Van Veldhoven PP, Zhang L, Hanigan MH, Alexander H, Alexander S. (2005) Sphingosine-1-Phosphate Lyase Regulates Sensitivity of Human Cells to Select Chemotherapy Drugs in a p38-Dependent Manner. Molecular Cancer Research,3:287-296.
5.     Min J., Traynor D., Stegner A.L, Zhang L., Hanigan M.H., Alexander H., and Alexander S. (2005) Sphingosine kinase regulates the sensitivity of Dictyostelium Discoideum cells to the anticancer drug cisplatin. Eukaryotic Cell, 4:178-189
6.     Min J, Stegner A.L, Alexander H. and Alexander S. (2004) Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum based chemotherapy drugs. Eukaryotic Cell, 3:795-805
7.    Jaeger S#, Min J#, Nigsch F, Camargo M, Hutz J, Cornett A, Cleaver S, Buckler A, Jenkins J. L. Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer. Journal of Biomolecular Screening. 2014;19(5):791-802.
8.      Zeng Y#, Nie C#, Min J#, Liu X#, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW. Novel loci and pathways significantly associated with longevity. Scientific Reports 2016; 6:21243.
 
合作作者论文
1.     Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice. Xin Y, Gao H, Wang J, Qiang Y, Imam MU, Li Y, Wang J, Zhang R, Zhang H, Yu Y, Wang H, Luo H, Shi C, Xu Y, Hojyo S, Fukada T, Min J, Wang F. Cell Discovery. 2017 Jul 18; 3:17025. doi: 10.1038/celldisc.2017.25.
2.     Dietary intake of heme iron and body iron status are associated with the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Zhao L, Lian J, Tian J, Shen Y, Ping Z, Fang X, Min J, Wang F. Asia Pac J Clin Nutr. 2017;26(6):1092-1106. doi: 10.6133/apjcn.022017.09.
3.      An P, Jiang L, Guan Y, Wang H, Wang J, Tian Y, Yang W, Shi Y, Xue J, Min J, Wang F*. Identification of hereditary hemochromatosis pedigrees and a novel SLC40A1 mutation in Chinese population. Blood Cells, Molecules, and Diseases. 2017, 63:34-36.
4.    Fang X, Wang K, Han D, He X, Wei J, Zhao L, Imam MU, Ping Z, Li Y, Xu Y, Min J, Wang F*. Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies. BMC Medicine 2016, 14, 210.
5.     Zeng Y, Chen H, Ni T, Ruan R, Nie C, Liu X, Feng L, Zhang F, Lu J, Li J, Li Y, Tao W, Gregory SG, Gottschalk W, Lutz MW, Land KC, Yashin A, Tan Q, Yang Z, Bolund L, Ming Q, Yang H, Min J, Willcox DC, Willcox BJ, Gu J, Hauser E, Tian XL, Vaupel JW. Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages. Rejuvenation Research. 2016;19(3):195-203.
6.      Fang X, Wang H, An P, Min J, and Wang F*. Cardiomyocyte-specific deletion of ferroportin using MCK-Cre has no apparent effect on either cardiac iron homeostasis. International Journal of Cardiology, 2015 Dec 15;201:90-2.
7.     Mu M, An P, Shen X, Wu Qian, Shao D, Wang H, Zhang Y, Zhang S, Yao H, Min J, Wang F*. The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression. Journal of Nutritional Biochemistry. 2015;10.015.
8.     Zhou Q., Derti A., Ruddy D., Rakiec D., Kao I., Lira M, Gibaja V, Chan H, Yang Y, Min J, Schlabach M, Stegmeier F. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Research. 2015 May 15;75(10):1949-58.
9.      Fang X, An P, Wang H, Wang X, Shen X, Li X, Min J, Liu S and Wang F. Dietary intake of heme iron and risk of cardiovascular disease: a dose-response meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis, 2015; 25(1): 24-35.
10.     Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao J. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. eLife.2014; e01763.
11.    Sridevi P, Alexander H, Laviad EL, Min J, Mesika A, Hannink M, Futerman AH, Alexander S. (2010) Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Exp Cell Res. 316(1):78-91.
12.    Driessche NV, Alexander H, Min J, Kuspa A, Alexander S and Shaulsky G. (2007) Global Transcriptional Responses to Cisplatin in Dictyostelium discoideum Identify Potential Drug Targets. PNAS, 104(39):15406-11
13.    Huang T#, Lan L#, Fang X, An P, Min J, Wang F*. Promises and Challenges of Big Data Computing in Health Sciences. Big Data Research, 2015, 2–11.  



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