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赵永超

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赵永超,博士,浙江大学转化医学研究院研究员,浙江大学医学院附属第一医院卫生部多器官联合移植研究重点实验室研究员、博士生导师。长期致力于肿瘤发生的分子机制研究,在肿瘤细胞信号调控、肿瘤发生和发展的分子机理以及抗肿瘤药物作用机制等方面积累了丰富的理论和研究经验。迄今为止,在国际权威刊物上发表SCI论文25篇,包括Molecular CellDevelopmental CelleLife等一作或共同一作12篇,影响因子总和达178,主持国家自然科学基金面上项目、浙江省自然科学基金杰出青年项目、浙江大学多学科交叉种子基金和Susan G. Komen for the Cure基金各1项,2015年入选浙江省“千人计划”。

教育经历

  2002/9 - 2008/1,清华大学,生物学,博士

  1998/9 - 2002/7,厦门大学,生物科学,学士

工作经历

  2015/1 - 至今,浙江大学,附属第一医院,研究员

  2015/1 - 至今,浙江大学,转化医学研究院,研究员

 2008/7 - 2014/12,美国密歇根大学,放射肿瘤系,博士后

研究领域

    1. mTOR信号通路抑制因子DEPTOR在肿瘤发生中的生理功能;

 2. Cullin-RING Ligase (CRL) E3 泛素连接酶在肿瘤发生中的调节功能;

            3. Neddylation信号通路在肿瘤发生中的调节作用。

代表论文

1. Cui DR, Xiong XF, Zhao YC#. Cullin-RING ligases in regulation of autophagy. Cell Division. 2016, 11:8. (IF=2.278)

2. Xu J, Zhou WH, Yang F, Chen GA, Li HM, Zhao YC, Liu PY, Li H, Tan MJ, Xiong XF, Sun Y. The βTrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications. (IF=11.329) (in press).

3. Zhou XC, Tan MJ, Nyati MK, Zhao YC, Wang GX, Sun Y. Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo. PNAS. 2016 May 9. pii: 201522367. [Epub ahead of print]. (IF=9.674)

4. Klionsky DJ, et al, Zhao YC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016, 12(1):1-222. (IF=11.753)

5. Zhao YC, Morgan MA, Sun Y. Targeting neddylation pathways to inactivate Cullin-RING ligases for anti-cancer therapy. Antioxidants & Redox Signaling. 2014, 21(17):2383-2400. (IF=7.407)

6. Xiong XF*, Zhao YC*, Tang F, Wei DP, Wang X, Thomas D, Zheng P, Liu Y, Sun Y. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. 2014, 3:e02236. (IF=9.322) * co-first author

7. Li H, Sun GY, Zhao YC, Thomas D, Greenson JK, Zalupski MM, Ben-Josef E, Sun Y. DEPTOR has growth suppression activity against pancreatic cancer cells. Oncotarget. 2014, 5(24):12811-12819. (IF=6.359)

8. Zhou WH, Xu J, Zhao YC, Sun Y. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget. 2014, 5:6746-6755. (IF=6.359)

9. Li H, Tan MJ, Jia LJ, Wei DP, Zhao YC, Chen GA, Zhao LL, Thomas D, Bear D, Sun Y. Inactivation of Sag/Rbx2/Roc2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. Journal of Clinical Investigation. 2014, 124: 835-846. (IF=13.215)

10. Zhao YC, Sun Y. The FBW7-KLF2 axis regulates endothelial functions. Cell Research. 2013, 23:741-743. (IF=12.413)

11. Zhao YC, Sun Y. Cullin-RING ligases as attractive anti-cancer targets. Current Pharmaceutical Design. 2013, 19:3215-3225. (IF=3.452)

12. Yang D*, Zhao YC*, Liu J, Sun Y, Jia LJ. Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. Autophagy. 2012, 8: 1856-1858. (IF=11.753) * co-first author

13. Zhao YC, Xiong XF, Jia LJ, Sun Y. Targeting Cullin-RING ligases by MLN4924 induces autophagy by modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease. 2012, 3: e386. (IF=5.014)

14. Zhao YC, Sun Y. CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome? Cell Research. 2012, 22:1224–1226. (IF=12.413)

15. Zhao YC, Sun Y. Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: Therapeutic application. Neoplasia. 2012, 14: 360-367. (IF=4.252) (Cover story)

16. Yang D, Zhao YC, Li A, Wang SM, Wang GX, Sun Y. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast Cancer Research and Treatment, 2012, 133:189-99. (IF=3.940)

17. Zhao YC, Xiong XF, Sun Y. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCFβTrCP E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell. 2011, 44: 304-316. (Research Highlight by Nature Reviews Molecular Cell Biology) (IF=14.018)

18. Tan MJ*, Zhao YC*, Kim SJ, Liu M, Jia LJ, Saunders TL, Zhu Y, Sun Y. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Developmental Cell. 2011, 21: 1062-1076. (IF=9.708) * co-first author

19. Xiong XF, Zhao YC, He HB, Sun Y. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene, 2011, 30: 1798–1811. (IF=8.459)

20. Tan MJ, Zhu YM, Kovacev J, Zhao YC, Pan ZQ, Spitz, DR, Sun Y. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells. Free Radical Biology and Medicine, 2010, 49: 976-983. (IF=5.736)

21. Zhao YC*, Shao W*, Wei HJ, Qiao JY, Lu Y, Sun YM, Mitchelson K, Cheng J, Zhou YX. Development of a novel oligonucleotide array-based transcription factor assay platform for genome-wide active transcription factor profiling in Saccharomyces cerevisiae. Journal of Proteome Research. 2008, 7: 1315-1325. (IF=4.245) * co-first author

22. Yang Q*, Zhao YC*, Xiong Q, Cheng J. Rapid chip-based capillary electrophoretic mobility shift assay with negative pressure injection for the binding study of transcription factor Abf1 in Saccharomyces cerevisiae. Electrophoresis. 2008, 29: 5003-5009. (IF=3.028) * co-first author

23. Qiao JY, Shao W, Wei HJ, Sun YM, Zhao YC, Xing WL, Zhang L, Mitchelson K, Cheng J. Novel high-throughput profiling of human transcription factors and its use for systematic pathway mapping. Journal of Proteome Research, 2008, 7: 2769-2779. (IF=4.245)

24. Sun YM, Zhang Y, Zeng LZ, Wu JP, Wei L, Ren AH, Shao W, Qiao JY, Zhao YC, Zhang L, Mitchelson K, Cheng J. Broad profiling of DNA-binding transcription factor activities improves regulatory network construction in adult mouse tissues. Journal of Proteome Research, 2008, 7: 4455-4464. (IF=4.245)

25. Yin HY, Zhao YC, Zhang Y, Zhang HW, Xu LZ, Zou ZM, Yang WP, Cheng J, Zhou YX. Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent. Biotechnology Letters, 2006, 28:99-105. (IF=1.591)

26. Yin HY, Xu H, Zhao YC, Yang WP, Cheng J, Zhou Y.X. Cyclooxygenase- independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays. Biotechnology Letters, 2006, 28:1263-1270. (IF=1.591)

27. Shao W, Wei HJ, Qiao JY, Zhao YC, Sun YM, Zhou YX, Cheng J. Parallel profiling of active transcription factors using an oligonucleotide array-based transcription factor assay (OATFA). Journal of Proteome Research, 2005, 4:1451-1456. (IF=4.245)

招聘启事

  本实验室长期欢迎优秀的本科生、硕士、博士研究生和博士后加盟,请有意者直接与赵永超老师联系

联系方式

电话:0571-86971963

电子信箱:yongchao@zju.edu.cn

 

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