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陆林宇

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陆林宇
 
浙江大学转化医学研究院/附属妇产科医院,教授、博士生导师
 
受教育经历
 
2003/01-2007/04,香港大学,生物化学系,博士
1999/09-2002/06,香港大学,生物化学系,学士
1998/09-1999/06,南京大学,生物化学系,本科(后转学去香港大学)
 
研究工作经历
 
2014/09-至今,浙江大学,医学院,教授、博士生导师
2012/05-2014/08,美国密歇根大学,医学院,研究员 (Research Investigator)
2007/05-2012/04,美国密歇根大学,医学院,博士后 (Research Fellow)
2002/09-2003/12,香港大学,生物化学系,研究助理 (Research Assistant)
 
主要研究方向
 
DNA损伤修复与精子发生、DNA损伤修复与妇科肿瘤
 
主持或参加科研项目及人才计划项目情况
 
1. 浙江省千人计划2014年入选者。
2. 国家自然科学基金面上项目,BRCA1在男性精母细胞减数分裂中的作用,2015-2018,主持
3. 浙江省自然科学基金杰出青年项目,蛋白质泛素化在男性精母细胞减数分裂中的调控,2015-2018,主持
4. 国家重点研发计划,人类配子发生、成熟障碍与胚胎停育的分子机制,2016-2020 ,子课题负责人
 
代表性文章
 
1. Liu Y, Zhang B, Meng X, Korn MJ, Parent JM, Lu LY*, Yu X*. (2017) UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures. Epigenetics,
12:551-560. 
 
2. Han D, Liang J, Lu Y, Xu L, Miao S, Lu LY, Song W, Wang L. (2016) Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway. PLoS One, 11:e0155476.
 
3. Liu Y, Zhang B, Kuang H, Korakavi G, Lu LY*, Yu X*. (2016) Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.  Journal of Biological Chemistry, 291:13679-88.
 
4. Lu LY*, Yu X*. (2015) CHFR is important for the survival of male premeiotic germ cells. Cell Cycle, 14:3454-60.
 
5. Lu LY*, Yu X*. (2015) Double-strand break repair on sex chromosomes: challenges during male meiotic prophase. Cell Cycle, 14:516-525.
 
6. Lu LY*, Kuang H, Korakavi, Yu X*. (2015) Topoisomerase II regulates the maintenance of DNA methylation. Journal of Biological Chemistry, 290: 851-860.
 
7. Li M, Lu LY, Yang CY, Wang S, Yu X. (2013) The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response. Genes & Development, 27: 1752-68.
 
8. Lu LY, Xiong Y, Kuang H, Korakavi, Yu X. (2013) Regulation of the DNA damage response on male meiotic sex chromosomes. Nature Communications, 4:2105.
 
9. Lu S, Lu LY, Liu MF, Yuan QJ, Sham MH, Guan XY, Huang JD. (2011) Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood. Neurobiology of Disease, 45: 215-233.
 
10. Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X. (2011) Chfr and RNF8  synergistically regulate ATM activation. Nature Structural & Molecular Biology,18: 761-768.
 
11. Wu J, Lu LY, Yu, X. (2010) Role of BRCA1 in DNA damage response. Protein&Cell. 1, 117-123.
 
12. Lu LY, Wu J, Ye L, Gavrilina GB, Saunders TL, Yu X. (2010) RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Developmental Cell, 18:371-384.
 
13. Lu LY, Yu X. (2009) The balance of Polo-like kinase 1 in tumorigenesis. Cell Division, 4:4.
 
14. Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. (2009) Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response. Molecular and Cellular Biology, 29:849-860.
 
15. Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. (2008) Aurora a is essential for early embryonic development and tumor suppression. Journal of Biological Chemistry, 283:31785-31790.
 

 

16. Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. (2008) Polo-like Kinase 1 is Essential for Early Embryonic Development and Tumor Suppression. Molecular and Cellular Biology, 28:6870-6876. 


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