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沈承勇

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个人资料

姓名   沈承勇
地址   浙江杭州凯旋路268号中心北楼226室
联系电话  18658834963
电子邮箱  cshen@zju.edu.cn
主页   http://itm.zju.edu.cn/redir.php?catalog_id=4594&object_id=4633
教育与职业
06/2015-现在     研究员,博导,独立 PI,浙江大学转化医学院,浙一医院
02/2014-05/2015  助理研究员( Research Assistant Scientist),美国乔治亚医学院
12/2008-02/2014  博后,美国乔治亚医学院,神经再生医学系
09/2001-07/2008  博士,中科院上海生化细胞所
09/1997-07/2001  学士,南开大学
 
学术背景
  
神经突触是神经元传递神经信号的基本功能单位。本人以神经肌肉接头和大脑神经元突触为模型,长期研究突触形成和可塑性变化的生理机制,突触障碍导致神经疾病的病理机制,以及探索转化应用。主要: 1)发现并鉴定运动神经元疾病(神经自身免疫病重症肌无力症)的新致病靶点及机制; 2)发现大脑皮层神经元兴奋性突触形成及障碍的新机制。共发表论文 28篇,其中以第一或通讯作者(含共同)发表在Journal of Clinical Investigation, Nature Neuroscience, PNAS, JBC, Neuroscience等杂志。主要成果被 Nature reviews Neuroscience, Nature reviews Neurology, Lancet Neurology等杂志正面引用,共超过 1200次。授权4项中美专利。担任Frontiers in Behavior Neuroscience杂志编委。担任Scientific Report, Molecular Brain, Experimental Neurology等十多个国际杂志特邀审稿人,国家自然基金评审员。入选浙江大学百人计划、浙江省自然基金杰出青年。获国家自然基金委面上项目 (2017-2020),国家科技部干细胞与转化重点专项 (2017-2021),浙江大学转化院院长种子基金 (2017-2018)资助。 
研究方向
1. 神经突触发育及运动神经环路建立的分子机制
2. 神经突触疾病(如痴呆,运动神经元疾病,肌肉萎缩症等)病理机制及转化应用
 
学术论文
1.Wang J*, Xiao Y*, Zhang K, Luo B#, Shen C#. Introducing autoimmunity at the synapse by a novel animal model of experimental autoimmune myasthenia gravis. Neuroscience. 2018,15;374:264-270
2. Shen C, Xiong WC, Mei L. LRP4 in neuromuscular junction and bone development and diseases. Bone. Nov;80:101-8, 2015.
3. Shen C*, Lu Y*, Zhang B*, Figueiredo D, Bean J, Jung J, Wu H, Barik A, Yin DM, Xiong WC, Mei L. Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis. Journal of Clinical Investigation 123:5190­202, 2013.
4. Shen C, Xiong WC, Mei L. Caspase-3, shears for synapse pruning. Developmental Cell. 28:604-606, 2014.
5. Tao Y*, Chen YJ*, Shen C* (共一作 ), Lee D, Marchetto S, Gao TM, Borg JP, Xiong WC, Mei L. Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons. Nature Neuroscience.16:290 -299, 2013
6. Tao Y*, Shen C*,# (共一作,共通讯 ), Luo S*, Traoré W*, Marchetto S, Santoni MJ, Xu L, Wu B, Shi C, Liu X, Zhao K, Xiong WC, Borg JP#, Mei L#. Role of Erbin in ErbB2­dependent breast tumor growth. Proc Natl Acad Sci U S A. 111(42):4429-38, 2014
7. Zhang B*, Shen C* (共一作), Bealmear B, Ragheb S, Xiong WC, Lewis R, Mei L. Autoantibodies to agrin in myasthenia gravis patients. PLOS.One. 9(3), 2014
8. Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma­secretase.  J Biol Chem. 283:17721-30, 2008.
9. Zhao K, Shen C, Lu Y, Huang Z, Li L, Rand CD, Pan J, Sun XD, Tan Z, Wang H, Xing G, Cao Y, Hu G, Zhou J, Xiong WC, Mei L. Muscle Yap Is a Regulator of Neuromuscular Junction Formation and Regeneration. J Neurosci. 2017,37:3465­3477.
10. Rivner M, Liu S, Quarles B, Fleenor B, Shen C, Pan J, Mei Lin. Agrin and LRP4 antibodies in ALS. Muscle and Nerve 2017, 55:430-432.
11. Li L*, Cao Yu*, Wu HT, Ye XC, Shen C, Barik A, Xie X, Gan L, Su H, Xiong WC, Mei L. Rapsyn serves as an E3 ligase for synapse formation. Neuron, 2016, 92:1007­1019.
12. Sun XD, Li L, Liu F, Huang ZH, Bean JC, Jiao HF, Barik A, Kim SM, Wu H, Shen C, Tian Y, Lin TW, Bates R, Sathyamurthy A, Chen YJ, Yin DM, Xiong L, Lin HP, Hu JX, Li BM, Gao TM, Xiong WC, Mei L. Lrp4 in astrocytes modulates glutamatergic transmission. Nature Neuroscience. 2016,19:1010-8.
13. Marino M, Scuderi F, Samengo D, Saltelli G, Maiuri MT, Shen C, Mei L, Sabatelli M, Pani G, Antonini G, Evoli A, Bartoccioni E. Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis. PLOS One. 2015 Aug 18;
14. Wu HT*, Barik A*, Lu YS, Bowman A, Shen C, Li L, Sathyamurthy A, Lin T, Xiong WC, Mei L. Slit2 as a β-catenin-dependent retrograde signal for presynaptic differentiation. Elife, Jul 10;4, 2015.
15. Xiong L*, Jung J*, Wu HT*, Xia WF, Pan JX, Shen C, Mei L, Xiong WC. LRP4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption. Proc Natl Acad Sci U S A,112: 3487-92, 2015.
16. Lisak RP, Zhang B, Shen C, Mei L, Drachman DB, Kaminski HJ. Neuromuscular junction as Achilles' heel: Yet another autoantibody? Neurology. 84(2): 214-15, 2015
17. Sathyamurthy A, Yin DM, Barik A, Shen C, Bean J, She JX, Xiong WC, Mei L. ErbB3-regulayed proliferation of Bergmann glial cell is required for normal cerebellar lamination. Development 2015 Jan.6
18. D-M Yin, Y-J Chen, S Liu, H Jiao, C Shen, A Sathyamurthy, T W Lin, W-C Xiong, B­M Li, L Mei and C Bergson Calcyon stimulates neuregulin 1 maturation and signaling. Molecular Psychiatry 2014 Oct. 28. 
19.Barik A*, Lu Y*, Sathyamurthy A, Bowman A, Shen C, Xiong WC, Mei L. LRP4 is critical for neuromuscular junction maintenance. J Neurosci Oct.15. 2014.
20. Yin DM*, Chen YJ*, Lu YS, Bean JC, Sathyamurthy A, Shen C, Liu X, Lin TW, Smith CA, Xiong WC, Mei L. Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron. 78:644-57, 2013.
21. Wang CL, Tang FL, Peng Y, Shen C, Mei L, Xiong WC. VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1. Biol Open. 12:1248-57, 2012.
22. Liang C*, Tao Y*, Shen C, Tan Z, Xiong WC, Mei L. Erbin is required for myelination in regenerated axons after injury. J Neurosci. 32:15169-80, 2012.
23. Wu HT, Lu Y, Shen C, Patel N, Gan L, Xiong WC, Mei L. Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation. Neuron. 75:94-107, 2012.
24. Wen L*, Tang FL*, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Brann D, Kim TW, Yan R, Mei L, Xiong WC. VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol. 195:765-79, 2011.
25. Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC, Mei L. Specific regulation of NRG1 isoform expression by neuronal activity.  J Neurosci. 31:8491-501, 2011.
26. Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci. 31:15-25, 2011.
27. Zhang K*, Li L*, Huang C, Shen C, Tan F, Xia C, Liu P, Rossant J, Jing N. Distinct functions of BMP4 during different stages of mouse ES cell neural commitment. Development. 137:2095-105, 2010.
28. Tang K, Wang C, Shen C, Sheng S, Ravid R, Jing N. Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639. Eur J Neurosci.18: 102-8, 2003.
 
 
授权发明专利
1. Mei L, Xiong WC, Zhang B, Shen C. Detection and treatment of LRP4-associated neurotransmission disorders. (USA Invention Patent) US 9244082 B2 Filing Date: 2013.04.20; Publish Date: 2016.01.26
2.   Mei L, Xiong WC, Shen C, Tao YM, Luo SW. Methods of using ErbB2 conjugate peptides. (USA Invention Patent) US 9493542 B2 Filing Date: 2014.02.24; Publish Date: 2016.11.15
3. 梅林,陶艳梅,沈承勇,熊文诚,罗诗文 . Erbin抑制剂在制备肿瘤药物中的作用中国专利号: CN 103212077 B 申请时间:2013.04.09 授权时间:2015.09.23
4. 景乃禾,唐珂,王晨,沈承勇人淀粉样蛋白前体蛋白 639、其编码序列及用途中国专利号: CN 100335500C 申请时间:2003.06.27 授权时间:2007.09.05.
 
奖励与学术
2016-至今 中国细胞生物学会会员
2016-至今 中国生物化学与分子生物学会会员
2015-至今 中国神经科学年会会员
2009-至今 神经科学年会会员
2008年    中科院三好学生奖
1998年    南开大学三等奖
杂志审稿
Scientific Report (2015 -);
Molecular Brain (2015 - );
Experimental Neurology (2014 - );
European Journal of Neurology (2014 -);
BBA-Biomembranes (2014 - );
Molecular and Cellular Biochemistry (2014 - );
Neuroscience (2013 - );
Journal of Proteomics and Genomics Research (2013 -)
PLOS.One (2010 - ); 
Etc 


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