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魏文毅

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 教育背景

1989-1993  大学本科,微生物系,山东大学,济南,中国

1993-1996  硕士,生物化学工程,中国科学院化工冶金研究所,北京,中国

1996-2002  博士,分子细胞及生物化学系,布朗大学,罗德岛,美国

2002-2005  Research Associate,医学肿瘤系,Dana-Farber 肿瘤研究所,波士顿,美国(导师:William G. KaelinJr. 教授)

研究工作经历

2005-2006  讲师,医学肿瘤系,Dana-Farber 肿瘤研究所,哈佛医学院,波士顿,美国

2006-2012  助理教授,病理系,哈佛医学院,波士顿,美国

2012-      副教授,病理系,哈佛医学院,波士顿,美国

研究领域

1Cullin-RING ligaseCRL泛素连接酶在肿瘤发生发展中的作用及机理

2蛋白质的磷酸化修饰与肿瘤的关系发生发展中的作用及机理

关键实验技术

1检测蛋白泛素化和类泛素化的生化分析

2细胞增殖、凋亡、自噬和衰老的细胞生物学检测技术,

3转基因小鼠动物模型构建及后续肿瘤形成的分析

4基因过表达及CRISPR沉默的分子生物学技术。

5组织学,病理学常规技术手段

转化潜能

1小分子泛素连接酶抑制剂的抗癌作用

2小分子去泛素化酶抑制剂的抗癌作用

近期主要论著 (总数96篇)

1. Gao, D., Inuzuka, H., Tseng, A., Chin, R., Toker, A. and Wei, W. (2009) Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APC/Cdh1-medaited Skp2 destruction. Nature Cell Biology11(4): 397-40

2. Inuzuka, H., Tseng, A., Gao, D., Zhai, B., Zhang, Q., Shaik, S., Wan, L., Ang, X.L., Mock, C., Yin, H., Stommel, J.M., Gygi, S., Lahav, L., Asara, J., Xiao, Z., Kaelin, W. G., Jr., Harper, J. W. and Wei, W. (2010) Phosphorylation by Caesin Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFß-TRCP ubiquitin ligase. Cancer Cell 18(2): 147-159 

3. Gao, D., Wan, L., Inuzuka, H., Berg, A. H., Tseng, A., Zhai, B., Shaik, S., Bennet, E., Tron, A. E., Gasser, J.A., Lau, A., Gygi, S., Harper, J. W., DeCaprio, J. A., Toker, A. and Wei, W. (2010) Rictor forms a complex with Cullin-1 to promote SGK1 ubiqutination and destruction. Molecular Cell39(5): 797-808

4. Inuzuka, H., Shaik, S., Onoyama, I., Tseng, A., Gao, D., Maser, R., Zhai, B., Wan, L., Gurierrez, A., Lau, A., Xiao, Y., Christie, A., Aster, J., Settleman, J., Gygi, S, Kung, A. L., Look, T., Nakayama, K. I., DePinho, R. A. and Wei, W. (2011) SCFFbw7 regulates cellular apoptosis by targeting the Mcl-1 oncoprotein for ubiquitination and destruction. Nature 471:104-9.

5. Gao, D.*, Inuzuka, H.*, Tan, M.*, Fukushima, H., Locasale, J. W., Liu, P., Zhai, B., Wan, L., Shaik, S., Lyssiotis, C.A., Gygi, S. P., Toker, A., Cantley, L. C., Asara, J. M., Harper, J. W.# and Wei, W.# (co-corresponding author) (2011) mTOR drives its own activation via SCFß-TRCP-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell 44(2): 290-303

6. Wan, L. *, Zou, W. *, Gao, D., Inuzuka, H., Fukushima, H., Berg, A. H., Drapp, R., Shaik, S., Hu, D., Lester, C., Eguren, M., Malumbres, M., Glimcher, L. H. and Wei, W. (2011) Cdh1 Regulates Osteoblast function through an APC/C-independent modulation of Smurf1. Molecular Cell 44(5): 721-33

7. Inuzuka, H.*, Gao, D.*, Finley, L., Yang, W., Wan, L., Fukushima, H., Chin, Y. C., Zhai, B., Shaik, S., Lau, A. W., Wang, Z., Gygi, S. P., Nakayama, K., Teruya-Feldstein, J., Toker, A., Haigis, M., Pandolfi, P.P. and Wei, W. (2012) Acetylation-Dependent Regulation of Skp2 Function. Cell 150(1): 179-193

8. Liu, P., Gao, D., Wan, L., Inuzuka, H., Fukushima, H., Lazorchak, A. S., Wang, Z., Yu, Y., Arojo, O., Liu, D., Zhai, B., Yuan, M., Shai, S., Gygi, S. P., Asara, J. M., Blenis, J., Su, B. and Wei, W. (2013) Sin1 phosphorylationimpairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis. Nature Cell Biology15(11): 1340-1350

9. Liu, P., Bagley, M., Inuzuka, H., Ginzberg, M., Gao, D., Tsou, P., Kim, B. M., Wan, L., Singh, A., Zhai, B., Yuan, M., Wang, Z., Gygi, S. P., Asara, J. M., Lee, T. H., Lu, K. P., Toker, A., Kirschner, M. W., Cantley, L.C. and Wei, W. (2014) Cell cycle-regulated activation of Akt kinase by phosphorylation of its carboxyl-terminal terminus.  Nature 508(7497):541-5

10. Liu, P., Gan, W., Chin, Y. R., Ogura, K., Guo, J., Zhang, J.,Wang, B., Blenis, J., Cantley, L.C., Toker, A., Su, B.# and Wei, W.# (2015) PtdIns(3,4,5)P3-dependent Activation of the mTORC2 Kinase Complex.Cancer Discovery5(11):1194-209.

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