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熊秀芳

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 熊秀芳

浙江大学转化医学研究院 副教授
浙江大学华家池校区中心北楼
 
教育经历
2002.9-2007.7,中科院生物物理所,博士
1998.9-2002.7,厦门大学生命科学院,学士
 
研究经历
2015.1至今,浙江大学转化医学研究院,副教授
2008.3-2014.12,密歇根大学放射肿瘤学系,博士后
 
研究领域
1)蛋白Neddylation修饰和Cullin-RING Ligase (CRL)泛素连接酶在肿瘤发生发展中的作用及机制;
2)核糖体蛋白RPS27L在肿瘤发生发展中的作用及机制。
 
转化潜能
1)靶向蛋白Neddylation通路的小分子抗癌药物的研发;
2)靶向CRL泛素连接酶的小分子抗癌药物的研发。
 
近期发表文章
1.  Wang J, Cui D, Gu S, Chen X, Bi Y, Xiong X, Zhao Y*. Autophagy regulates apoptosis by targeting NOXA for degradation. Biochimica et Biophysica Acta 2018 May 17;1865(8):1105-1113.
 
2.  Gu S, Cui D, Chen X, Xiong X*, Zhao Y*. PROTACs: An emerging targeting technique for protein degradation in drug discovery. BioEssays 2018 Feb 23: 1700247. (* co-corresponding author)
Highlight by Advanced Science News (https://www.advancedsciencenews.com/protacs-approach-elimination-disease-causing-proteins/?from=groupmessage&isappinstalled=0)
 
3.   Zhao Y*, Tan M, Liu X, Xiong X*, Sun Y*. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death & Disease. 2018 Feb 2;9(2):145. (* co-corresponding author)
 
4.  Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y*. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications 2017 Jan 16; 8:14002.
 
5.  Xu X, Xiong X*, Sun Y*. The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity. Science China Life Sciences 2016 Jul;59(7):656-672. (* co-corresponding author)
 
6.    Cui D, Xiong X, Zhao Y*. Cullin-RING ligases in regulation of autophagy.Cell Division 2016 Jun 10;11:8.
 
7.   Xiong X#, Zhao Y#, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y*. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. 2014, Aug 21: e02236. doi: 10.7554/eLife.02236. (#equal contribution)
Recommended by Faculty of 1000 as being of special significance in its field(http://f1000.com/prime/718539829?subscriptioncode=7465b73f-8aa5-47a9-972e-39e4ef0a4a69)
 
8.  Zhao Y, Xiong X, Jia L, Sun Y*. Targeting Cullin-RING ligases by MLN4924 induces autophagy by modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease. 2012 Sep 6; 3: e386.
 
9.   Xiong X, Zhao Y, He H, Sun Y*. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene 2011 Apr 14;30(15) :1798-1811.
 
10. Zhao Y, Xiong X, Sun Y*. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCFβTrCP E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell 2011 Oct 21;44(2): 304-316.
Research highlight by Katharine H. Wrighton. “Cell signaling: mTOR targets its own inhibitor” Nature Reviews Molecular Cell Biology 2011, 12: 769.
 
 
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