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冯晔

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冯晔                                 

理学博士,副教授

邮箱:pandafengye@zju.edu.cn

教育背景 

2000-2004 浙江大学,生物科学,学士

2004-2009 浙江大学,生物信息学,博士

研究方向

本课题组运用基因组学及生物信息学手段研究临床重要病原菌的致病、耐药及流行机制。尤其关注遗传信息的变化(如点突变、水平迁移等)如何影响病原菌的临床特性,以及这些变化如何响应环境选择压并在群体中散播。目前正在进行的工作如下:

1. 伤寒沙门菌的宿主特异性

2. 鲍曼不动杆菌的多重耐药性

3. 重要病原菌的全基因组分型

转化潜力

1. 探索细菌感染治疗的新策略

2. 构建基因组在线数据库跟踪重要病原菌的流行状况

最近发表

1. Hua X, Shu J, Ruan Z, Yu Y, Feng Y. Multiplication of blaOXA-23 is common in clinical Acinetobacter baumannii, but does not enhance carbapenem resistance. J Antimicrob Chemother. 2016 Dec;71(12):3381-3385.
2. Feng Y, Ruan Z, Shu J, Chen CL, Chiu CH. A glimpse into evolution and dissemination of multidrug-resistant Acinetobacter baumannii isolates in East Asia: a comparative genomics study. Sci Rep. 2016 Apr 13;6:24342. 
3. Ruan Z, Feng Y. BacWGSTdb, a database for genotyping and source tracking bacterial pathogens. Nucleic Acids Res, 2016, 44(D1): D682-687.
4. Lee C C, Feng Y, Chen S Y, Tsai C N, Lai M W, Chiu C H. Emerging Norovirus GII.17 in Taiwan. Clin Infect Dis, 2015, 61(11): 1762-1764.
5. Feng Y, Chen C L, Chen T H, Liang Y H, Chen H L, Lin C Y, Chiu C H. Application of next-generation sequencing to study ascitic microbiome in cirrhotic patients with or without spontaneous bacterial peritonitis. J Microbiol Immunol Infect, 2015, 48(5): 504-509.
6. Yu D, Pi B, Yu M, Wang Y, Ruan Z, Feng Y, Yu Y. Diversity and evolution of oligopeptide permease systems in staphylococcal species. Genomics, 2014, 104(1): 8-13.
7. Qu T, Feng Y, Jiang Y, Zhu P, Wei Z, Chen Y, Otto M, Yu Y. Whole genome analysis of a community-associated methicillin-resistant Staphylococcus aureus ST59 isolate from a case of human sepsis and severe pneumonia in China. PLoS One, 2014, 9(2): e89235.
8. Feng Y, Chiu C H. Predicting genetic and ecological characteristics of bacterial species by comparing the trajectories of dN/dS and dI/dS in bacterial genomes. Mol Biosyst, 2014, 10(2): 266-272.
9. Bao H X, Tang L, Yu L, Wang X Y, Li Y, Deng X, Li Y G, Li A, Zhu D L, Johnston R N, Liu G R, Feng Y, Liu S L. Differential efficiency in exogenous DNA acquisition among closely related Salmonella strains: implications in bacterial speciation. BMC Microbiol, 2014, 14: 157.

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