王建安实验室
王建安
教授,博士生导师
研究方向:围绕冠心病、心脏瓣膜病和心律失常的原创性和系统性研究
王建安

代表性论著

1.Tian Liang # , Feng Gao# , Jun Jiang # , Yao Wei Lu , Feng Zhang , Yingchao Wang , Ning Liu , Xuyang Fu , Xiaoxuan Dong , Jianqiu Pei , Douglas B Cowan , Xinyang Hu , Jian'an Wang* , Da-Zhi Wang* , Jinghai Chen* .

 Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction. Circulation. 2020;142:2196-2199.

IF=23.603共同通讯

2.JiaqiFan,XianFang,ChunhuiLiu,GangjieZhu,CodyR.Hou,JuboJiang,XinpingLin,LihanWang,YuxinHe,QifengZhu,StellaNg,ZexinChen,HaitaoHu,XianbaoLiu*,

Jian’anWang*,MartinB.Leon.

Brain Injury After Transcatheter Replacement of Bicuspid Versus Tricuspid Aortic Valves. Journal of the American College of Cardiology, 1 December 2020, Pages 2579-2590.

IF=20.589共同通讯.

3.Qingju Li#, Yinchuan Xu#, Kaiqi Lv#, Yingchao Wang, Zhiwei Zhong, Changchen Xiao, Keyang Zhu, Cheng Ni, Kan Wang, Minjian Kong, Xuebiao Li, Youqi Fan, Fengjiang Zhang, Qi Chen, Yi Li, Qian Li, Chengjia Liu, Jinyun Zhu, Shuhan Zhong, Jingyi Wang,Yongjian Chen, Jing Zhao, Dan Zhu, Rongrong Wu, Jinghai Chen, Wei Zhu, Hong Yu, Reza Ardehali, Jianyi(Jay) Zhang*, Jian’an Wang*, Xinyang Hu*. Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates. Science translational medicine. 2021 Mar 10;13(584):eabb0202. doi: 10.1126/scitranslmed.abb0202.

IF=16.304共同通讯

4.Xiao C#, Wang K, Xu Y, Hu H, Zhang N, Wang Y, Zhong Z, Zhao J, Li Q, Zhu D, Ke C, Zhong S, Wu X, Yu H, Zhu W, Chen J, Zhang J, Wang J*, Hu X*. Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b. Circulation Research. 2018 Aug 17;123(5):564-578.

IF=14.647 共同通讯

5.Jia L#, Wang Y, Wang Y, Ma Y, Shen J, Fu Z, Wu Y, Su S, Zhang Y, Cai Z*, Wang J*, Xiang M*. Heme Oxygenase-1 in Macrophages Drives Septic Cardiac Dysfunction via Suppressing Lysosomal Degradation of Inducible Nitric Oxide Synthase. Circ Res. 2018 Apr 18. pii: CIRCRESAHA.118.312910. doi: 10.1161/CIRCRESAHA.118.312910.

IF=14.647 共同通讯

6.Shen J#, Zhang N, Lin YN, Xiang P, Liu XB, Shan PF, Hu XY, Zhu W, Tang YL, Webster KA, Cai RZ, Schally A, Wang J*, Yu H*. Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and its Agonists. Circ Res. 2018 Apr 4. pii: CIRCRESAHA.117.312418. doi: 10.1161/CIRCRESAHA.117.312418. IF=14.647 共同通讯

7.Zhu K#, Wu Q#, Ni C#, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang J*. Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circ Res. 2018 Mar 30;122(7):958-969. doi: 10.1161/CIRCRESAHA.117.311578. IF=14.647 共同通讯

8.Nan J#, Hu H#, Sun Y#, Zhu L, Wang Y, Zhong Z, Zhao J, Zhang N, Wang Y, Wang Y, Ye J, Zhang L, Hu X, Zhu W*, Wang J*. TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression. Circ Res. 2017 Aug 4;121(4):392-410.doi:10.1161/CIRCRESAHA.117.311143.

 IF=14.467 共同通讯

9.Jiang J#, Hu X, Xiang M, Wang J*. Heart Center of SAHZU Transforming Into an Innovative Institute.CircRes. 2017 Sep 29;121(8):917-919. 

doi: 10.1161/CIRCRESAHA.117.311024. IF=14.467 共同通讯

10.Nan J#, Hu H#, Sun Y#, Zhu L, Wang Y, Zhong Z, Zhao J, Zhang N, Wang Y, Wang Y, Ye J, Zhang L, Hu X, Zhu W*, Wang J*. TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression. Circ Res. 2017 Aug 4;121(4):392-410.

 doi: 10.1161/CIRCRESAHA.117.311143. IF=14.467 共同通讯

11.Hu XY#, Xu YC, Zhong ZW, WuY, Zhao J, Wang YC, Cheng HF, Kong MJ, Zhang FJ, Chen Q, Sun JZ, Li Q, Jin J, Li QJ, Chen LH, Wang C, Zhan HW, Fan YQ, Yang Q, Yu L, Wu RR, Liang J, Zhu JY, Wang Y, Jin YP, Lin YF, Yan F, Jia LL, Zhu W, Chen JH, Yu H, Zhang JY*, Wang JA*. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization. Circulation Research. 2016 Mar 18;118(6):970-83. 通讯作者IF=11.551

12.Hu XY#, Yang HT, Zhu YG, Wang JA*, Dong E*, Chinese Basic Cardiovascular Research in Transition. Circulation Research. 2016 Jun 10;118(12):1876-9.  (review)IF=11.551共同通讯作者

13.Hu H#, Nan J, Sun Y, Zhu D, Xiao C, Wang Y, Zhu L, Wu Y, Zhao J, Wu R, Chen J, Yu H, Hu X, Zhu W*, Wang J*. Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-referfusion injury via dimerized STAT3. PNAS,2017;114(45):11908-11913. IF=9.412 共同通讯作者

14.Wang C#, Chen H#, Zhu W, Xu Y, Liu M, Zhu L, Yang F, Zhang L, Liu X, Zhong Z, Zhao J, Jiang J, Xiang M, Yu H, Hu X, Lu H, Wang J*. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):53-65. doi: 10.1161 IF=6.604共同通讯作者

15.Ye F#, Wang Y#, Wu C, Howatt DA, Wu CH, Balakrishnan A, Mullick AE, Graham MJ, Danser AHJ, Wang J*, Daugherty A*, Lu HS*. Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):150-155. IF=6.604 共同通讯作者

16.Liu X#, Hu D#, Zeng Z, Zhu W, Zhang N, Yu H, Chen H, Wang K, Wang Y, Wang L, Zhao J, Zhang L, Wu R, Hu X, Wang J*. SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction. Cell Death Dis. 2017 Apr 6;8(4):e2731.  IF=6.304

17.Hu XY#, Chen PP, Wu Y , Wang K, Xu YC , Chen H , Zhang  L, Wu RR, Webster KA, Yu H , Zhu W* , Wang JA*. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016 Jul;34(7):1846-58. IF = 5.902 共同通讯作者

18.KaixiangYu,ZhiruZeng,SiCheng,WangxingHu,ChenyangGao,FengLiu,JinyongChen,YiQian,DilinXu,JingZhao,XianbaoLiu*andJiananWang*.

TPP1EnhancestheTherapeuticEffectsofTransplantedAgedMesenchymalStemCellsinInfarctedHeartsviatheMRE11/AKTPathway. cell and developmental biology. 29October2020doi:10.3389/fcell.2020.588023. IF= 5.186共同通讯

19.DanZhu,PengWu,ChangchenXiao,WeiHu,TongtongZhang,XinyangHu,WeiChen*andJiananWang*.

InflammatoryCytokinesAlterMesenchymalStemCellMechanosensingandAdhesiononStiffenedInfarctHeartTissueAfterMyocardialInfarction.. cell and developmental biology. 23October2020doi:10.3389/fcell.2020.583700. IF=5.186共同通讯

20.Zhang N#, Ye F, Zhu W, Hu D, Xiao C, Nan J, Su S, Wang Y, Liu M, Gao K, Hu X, Chen J, Yu H, Xie X*, Wang JA*. Cardiac ankyrin repeat protein attenuates cardiomyocyte apoptosis by upregulation of Bcl-2 expression. Biochim Biophys Acta. 2016 Dec;1863(12):3040-3049. IF=5.128  共同通讯

21.Xianbao Liu#, Yuxin He, Qifeng Zhu, Feng Gao, Wei He, Lei Yu, Qijing Zhou, Minjian Kong, Jian’an Wang*. Supra‐annular structure assessment for self‐expanding transcatheter heart valve size selection in patients with bicuspid aortic valve. Catheter Cardiovasc Interv. 2018 Apr 1; 91(5): 986–994. Published online 2018 Feb 5. doi: 10.1002/ccd.27467.

22.Xian-bao Liu#, Yu-xin He, Chun-hui Liu, Li-han Wang, Feng Gao, Lei Yu, Ai-qiang Dong, Min-jian Kong, Ji-fang Chen, Yong Xu, Qi-jing Zhou, Min Yan, Wang J*. First-in-man implantation of the retrievable and repositionable VenusA-Plus valve. World J Emerg Med. 2018; 9(1): 64–66. doi: 10.5847/wjem.j.1920-8642.2018.01.010.

浙江大学转化医学研究院
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