1. Weiguo Xiang#, Lijie Zhao#, Xin Han#, Tianfeng Xu#, Steven Kregel#, Mi Wang#, Bukeyan Miao, Chong Qin, Mingliang Wang, Donna McEachern, Jianfeng Lu, Longchuan Bai, Chao-Yie Yang, Paul D. Kirchhoff, John Takyi-Williams, Lu Wang, Bo Wen, Duxin Sun, Mark Ator, Robert Mckean, Arul M. Chinnaiyan, Shaomeng Wang*. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity Against AR Mutants for the Treatment of AR+ Human Prostate Cancer. J. Med. Chem., 2023, 66, 13280-13303. (#Co-First Author).
2. Xin Han#, Lijie Zhao#, Weiguo Xiang#, Bukeyan Miao#, Chong Qin#, Mi Wang#, Tianfeng Xu, Donna McEachern, Jianfeng Lu, Yu Wang, Hoda Metwally, Chao-Yie Yang, Paul D Kirchhoff, Lu Wang, Aleksas Matvekas, John Takyi-Williams, Bo Wen , Duxin Sun, Mark Ator, Robert Mckean, Shaomeng Wang*. Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J. Med. Chem., 2023, 66, 8822-8843. (#Co-First Author).
3. Weiguo Xiang#, Lijie Zhao#, Xin Han#, Chong Qin, Bukeyan Miao, Donna McEachern, Yu Wang, Hoda Metwally, Lu Wang, Aleksas Matvekas, Bo Wen, Duxin Sun, Shaomeng Wang*. Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor (AR) for the Treatment of Advanced Prostate Cancer. J. Med. Chem., 2021, 64, 13487-13509. (#Co-First Author, Most Read Articles; 获Faculty Opinions (原F1000Prime)推荐)
4. Xin Han#, Lijie Zhao#, Weiguo Xiang#, Chong Qin, Bukeyan Miao, Donna McEachern, Yu Wang, Hoda Metwally, Lu Wang, Aleksas Matvekas, Bo Wen, Duxin Sun, Shaomeng Wang*. Strategies toward Discovery of Potent and Orally Bioavailable PROTAC Degraders of Androgen Receptor (AR) for the Treatment of Advanced Prostate Cancer. J. Med. Chem., 2021, 64, 12831-12854. (#Co-First Author)
5. Xin Han#, Lijie Zhao#, Weiguo Xiang, Chong Qin, Bukeyan Miao, Tianfeng Xu, Mi Wang, Chao-Yie Yang, Krishnapriya Chinnaswamy, Jeanne Stuckey, Shaomeng Wang*. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J. Med. Chem., 2019, 62, 11218-11231. (#Co-First Author, Most Read Articles; 获Faculty Opinions (原F1000Prime)推荐)
6. Xin Han#, Chao Wang#, Chong Qin#, Weiguo Xiang#, Ester Fernandez-Salas, Chao-Yie Yang, Mi Wang, Lijie Zhao, Tiangfeng Xu, Krishnapriya Chinnaswamy, James Delproposto, Jeanne Stuckey, Shaomeng Wang*. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J. Med. Chem., 2019, 62, 941-964. (#Co-First Author, Most Read Articles, ESI高被引论文)
7. Xin Han, Ningyuan Sun, Haoming Wu, Deyin Guo, Po Tien, Chune Dong, Shuwen Wu*, Hai-Bing Zhou*. Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors. J. Med. Chem., 2016, 59, 2139-2150.
8. Xin Han*, Yi Sun*. PROTACs: A novel strategy for cancer drug discovery and development. MedComm 2023, 4, e290. (*Co-Corresponding Author)
9. Xiaojuan Jia, Xin Han*. Targeting Androgen Receptor Degradation with PROTACs from Bench to Bedside. Biomed Pharmacother 2022, 158, 114112. (ESI高被引论文)
10. Xin Han*, Yi Sun*. Strategies for the discovery of oral PROTAC degraders aimed at cancer therapy. Cell Reports Physical Science 2022, 3, 101062. (*Co-Corresponding Author)
11. Xinjin Liu, Jinsen Liang, Yongshi Yu, Xin Han, Lei Yu, Feifei Chen, Zhichao xu, Qi Chen, Mengyu Jin, Chune Dong, Hai-Bing Zhou, Ke Lan, Shuwen Wu. Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA Dependent RNA Polymerase (RdRp). J. Med. Chem., 2022, 65, 3814-3832.
12. Yangbing Li, Jiuling Yang, Angelo Aguilar, Donna McEachern, Sally Przybranowski, Liu Liu, Chaoyie Yang, Mi Wang, Xin Han, Shaomeng Wang. Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J. Med. Chem., 2019, 62, 448-466. (ESI高被引论文)
