段胜仲实验室
段胜仲
教授、博士研究生导师
浙大口腔医院院长,浙江大学求是特聘教授
研究方向:(1)口腔疾病与全身系统性疾病交叉研究。
(2)转录调控与免疫调节在心血管疾病中的作用。
段胜仲

代表性论著

代表性论著:

1.      Meng X, Du L, Xu S, Zhou L, Chen B, Li Y, Chen C, Ye H, Zhang J, Tian G, Bai X, Dong T, Lin W, Sun M, Zhou K, Liu Y, Zhang W*, Duan S*. Periodontitis exacerbates pulmonary hypertension by promoting IFNg+ T cell infiltration in mice. Int J Oral Sci. 2024 Mar 28;16(1):27.

2.      Sun K, Wang YL, Hou CC, Shang D, Du LJ, Bai L, Zhang XY, Hao CM*, Duan SZ*. Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor. J Adv Res. 2024 Feb 8:S2090-1232(24)00053-5. doi: 10.1016/j.jare.2024.02.003. Online ahead of print.

3.      Fu JY, Huang SJ, Wang BL, Yin JH, Chen CY, Xu JB, Chen YL, Xu S, Dong T, Zhou HN, Ma XY, Pu YP, Li H, Yang XJ, Xie LS, Wang ZJ, Luo Q, Shao YX, Ye L, Zong ZR, Wei XD, Xiao WW, Niu ST, Liu YM, Xu HP, Yu CQ, Duan SZ*, Zheng LY*. Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity. Cell Metab. 2024 Mar 5;36(3):557-574.e10.

4.      Bai XB, Xu S, Zhou LJ, Meng XQ, Li YL, Chen YL, Jiang YH, Lin WZ, Chen BY, Du LJ, Tian GC, Liu Y, Duan SZ*, Zhu YQ*. Oral pathogens exacerbate Parkinson's disease by promoting Th1 cell infiltration in mice. Microbiome. 2023 Nov 17;11(1):254.

5.      Dong T, Xu S, Chen ZY, Liang YJ, Meng XQ, Niu CG, Yuan KY, Li PL, Duan SZ*, Huang ZW*. Prevotella intermedia Aggravates Subclinical Hypothyroidism. J Dent Res. 2023 Jul;102(7):814-824.

6.      Sun JY, Du LJ, Shi XR, Zhang YY, Liu Y, Wang YL, Chen BY, Liu T, Zhu H, Liu Y, Ruan CC, Gan Z, Ying H, Yin Z, Gao PJ, Yan X*, Li RG*, Duan SZ*. An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction. Sci Adv. 2023 Apr 5;9(14):eade4110.

7.      Xu S, Hu B, Dong T, Chen BY, Du LJ, Li YL, Chen YL, Tian GC, Bai XB, Liu T, Zhou LJ, Zhang WC, Liu Y, Ding QF, Zhang XQ*, Duan SZ*. Alleviate Periodontitis and its Comorbidity Hypertension using A Nanoparticle-embedded Functional Hydrogel System. Adv Healthc Mater. 2023 Aug;12(20):e2203337.

8.      Zhou LJ, Lin WZ, Meng XQ, Zhu H, Liu T, Du LJ, Bai XB, Chen BY, Liu Y, Xu Y, Xie Y, Shu R, Chen FM, Zhu YQ*, Duan SZ*. Periodontitis exacerbates atherosclerosis through Fusobacterium nucleatum-promoted hepatic glycolysis and lipogenesis. Cardiovasc Res. 2023 Jul 6;119(8):1706-1717.

9.      Du LJ, Sun JY, Zhang WC, Liu Y, Liu Y, Lin WZ, Liu T, Zhu H, Wang YL, Shao S, Zhou LJ, Chen BY, Lu H, Li RG*, Jia F*, Duan SZ*. NCOR1 maintains the homeostasis of vascular smooth muscle cells and protects against aortic aneurysm. Cell Death Differ. 2023 Mar;30(3):618-631.

10.   Zhou LJ, Lin WZ, Liu T, Chen BY, Meng XQ, Li YL, Du LJ, Liu Y, Qian YC, Zhu YQ*, Duan SZ*. Oral Pathobionts Promote MS-like Symptoms in Mice. J Dent Res. 2023 Feb;102(2):217-226.

11.   Chen BY, Lin WZ, Li YL, Bi C, Du LJ, Liu Y, Zhou LJ, Liu T, Xu S, Shi CJ, Zhu H, Wang YL, Sun JY, Liu Y, Zhang WC, Lu HX, Wang YH, Feng Q, Chen FX, Wang CQ, Tonetti MS, Zhu YQ*, Zhang H*, Duan SZ*. Roles of oral microbiota and oral-gut microbial transmission in hypertension. J Adv Res. 2023 Jan;43:147-161.

12.   Ma XX, Meng XQ, Wang YL, Liu Y, Shi XR, Shao S, Duan SZ*, Lu HX*. Ncor1 Deficiency Promotes Osteoclastogenesis and Exacerbates Periodontitis. J Dent Res. 2023 Jan;102(1):72-81.

13.   Yu F, Lian R, Liu L, Liu T, Bi C, Hong K, Zhang S, Ren J, Wang H, Ouyang N, Du LJ, Liu Y, Zhou L, Liu Y, Fang B*, Li Y*, Duan SZ*, Xia L*. Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22. ACS Nano. 2022 Jan 25;16(1):755-770.

14.   Li C, Sun XN, Chen BY, Zeng MR, Du LJ, Liu T, Gu HH, Liu Y, Li YL, Zhou LJ, Zheng XJ, Zhang YY, Zhang WC, Liu Y, Shi C, Shao S, Shi XR, Yi Y, Liu X, Wang J, Auwerx J, Wang ZV, Jia F*, Li RG*, Duan SZ*. Nuclear receptor corepressor 1 represses cardiac hypertrophy. EMBO Mol Med. 2019 Nov 7;11(11):e9127.

15.   Yi Y, Du L, Qin M, Chen XQ, Sun XN, Li C, Du LJ, Liu Y, Liu Y, Sun JY, Tang Z, Xu M, Fang B, Liu X*, Duan SZ*. Regulation of atrial fibrosis by the bone. Hypertension. 2019 Feb;73(2):379-389.

16.   Ai TJ, Sun JY, Du LJ, Shi C, Li C, Sun XN, Liu Y, Li L, Xia Z, Jia L, Liu J*, Duan SZ*. Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell Death Differ. 2018 Feb;25(2):319-329.

17.   Li C, Sun XN, Zeng MR, Zheng XJ, Zhang YY, Wan Q, Zhang WC, Shi C, Du LJ, Ai TJ, Liu Y, Liu Y, Du LL, Yi Y, Yu Y, Duan SZ*. Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction Through Modulating T-Cell Activation. Hypertension. 2017 Jul;70(1):137-147.

18.   Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ*, Liu Y*. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat Immunol. 2017 May;18(5):519-529.

19.   Zhang YY, Li C, Yao GF, Du LJ, Liu Y, Zheng XJ, Yan S, Sun JY, Liu Y, Liu MZ, Zhang X, Wei G, Tong W, Chen X, Wu Y, Sun S, Liu S, Ding Q, Yu Y, Yin H, Duan SZ*. Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance through ERα/HGF/MET Pathway. Diabetes. 2017 Jun;66(6):1535-1547.

20.   Sun XN, Li C, Liu Y, Du LJ, Zeng MR, Zheng XJ, Zhang WC, Liu Y, Zhu M, Kong D, Zhou L, Lu L, Shen ZX, Yi Y, Du L, Qin M, Liu X, Hua Z, Sun S, Yin H, Zhou B, Yu Y, Zhang Z, Duan SZ*. T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma. Circ Res. 2017 May 12;120(10):1584-1597.

21.   Yan S, Tang J, Zhang Y, Wang Y, Zuo S, Shen Y, Zhang Q, Chen D, Yu Y, Wang K, Duan SZ*, Yu Y*. Prostaglandin E2 promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4α/cholesterol 7α-hydroxylase pathway in mice. Hepatology. 2017 Mar;65(3):999-1014.

22.   Sun JY, Li C, Shen ZX, Zhang WC, Ai TJ, Du LJ, Zhang YY, Yao GF, Liu Y, Sun S, Naray-Fejes-Toth A, Fejes-Toth G, Peng Y, Chen M, Liu X, Tao J, Zhou B, Yu Y, Guo F, Du J, Duan SZ*. Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-kB pathways. Arterioscler Thromb Vasc Biol. 2016 May;36(5):874-85.

23.   Zhang WC, Zheng XJ, Du LJ, Sun JY, Shen ZX, Shi C, Sun S, Zhang Z, Chen XQ, Qin M, Liu X, Tao J, Jia L, Fan HY, Zhou B, Yu Y, Ying H, Hui L, Liu X, Yi X, Liu X, Zhang L, Duan SZ*. High salt primes a specific activation state of macrophages, M(Na). Cell Res. 2015 Aug;25(8):893-910.

24.   Usher MG#, Duan SZ#,*, Ivashchenko CY, Frieler RA, Berger S, Schütz G, Lumeng C, Mortensen RM*. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest. 2010 Sep;120(9):3350-64.

25.   Duan SZ, Usher MG, Mortensen RM. Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ Res. 2008; 102(3): 283-294.

26.   Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest. 2007; 117(3): 812-822.

27.   Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res. 2005; 97(4): 372-379.


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