2025年：
1. Xiong X*, Chen X, Shao S, Cui D, Qu R, Wang B, Ma Y, Pan H, Sun Y, Zhao Y*. DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase. Cell Death and Differentiation. 2025 Apr 1. doi: 10.1038/s41418-025-01497-5. Online ahead of print.
2. Cui D*, Shao S, Qu R, Chen X, Jiang S, Wang L, Gong L, Li T, Zhai D, Song W, Song P, Sun Y, Liang T*, Xiong X*, Zhao Y*. The FBXW7-RPAP2 Axis Controls the Growth of Hepatocellular Carcinoma Cells and Determines the Fate of Liver Cell Differentiation. Advanced Science. 2025 Apr;12(13):e2404718.
3. Shao S, Cui D, Zheng C, Xiong X*, Zhao Y*. WSB2 inhibits apoptosis and autophagy by targeting NOXA for degradation. MedComm. 2025 Jan 24;6(2):e70071.
4. Zhang F, Xiong X, Li Z, Wang H, Wang W, Zhao Y*, Sun Y*. RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis. EMBO Journal. 2025 Feb;44(4):1185-1219.
5. Xiong X, Zhao Y*, Sun Y*. SMURF1: A promising target for colon cancer therapy. Protein & Cell. 2025 Mar 8;16(3):157-160.
6. Lu X#, Wu X#, Li S#, Liang T, Yu Q, Zhang Y, Liu J, Li K, Liu Z, Cui M, Zhao Y, Han X, Jin R, Tan M, Chen X, Zhao Y, Zheng M*, Sun Y*, Zhou L*. Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries. Angewandte Chemie International Edition. 2025 Apr 13:e202505581. doi: 10.1002/anie.202505581. Online ahead of print.
2024年：
1. Zhang S#, Yu Q#, Li Z, Zhao Y*, Sun Y*. Protein neddylation and its role in health and diseases. Signal Transduction and Targeted Therapy. 2024 Apr 5;9(1):85.
2. Yao J#, Liang X#, Xu S#, Liu Y, Shui L, Li S, Guo H, Xiao Z, Zhao Y*, Zheng M*. TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD+/SIRT3/SOD2 Axis. Free Radical Biology and Medicine. 2024 Feb 1:211:47-62
2023年：
1. Liang X#, Yao J#, Cui D#, Zheng W, Liu Y, Lou G, Ye B, Shui L, Sun Y, Zhao Y*, Zheng M*. The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. Cell Death and Differentiation. 2023 Jun;30(6):1550-1562.
2. Li L#, Wang L#, Liu D, Zhao Y*. BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1. Cell Death Discovery. 2023 Aug 25;9(1):313.
3. Li Y, Zhou H, Liu P, Lv D, Shi Y, Tang B, Xu J, Zhong T, Xu W, Zhang J, Zhou J, Ying K, Zhao Y, Sun Y, Jiang Z, Cheng H, Zhang X, Ke Y*. SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis. Journal of Clinical Investigation. 2023 Feb 15;133(4):e162870. doi: 10.1172/JCI162870.
2022年：
1. Gong L#, Cui D#, Liu D#, Shen X, Pan H, Xiong X*, Zhao Y*. FBXW7 inactivation induces cellular senescence via accumulation of p53. Cell Death & Disease. 2022 Sep 14;13(9):788.
2. Ma Y#, Cui D#, Wang L#, Wang Y, Yang F, Pan H, Gong L, Zhang M, Xiong X*, Zhao Y*. P90 ribosomal S6 kinase confers cancer cell survival by mediating checkpoint kinase 1 degradation in response to glucose stress. Cancer Science. 2022 Jan;113(1):132-144
3. Wang Y#, Shen X#, Gong L, Zhao Y*, Xiong X*. Functional characterization of FBXL7 as a novel player in human cancers. Cell Death Discovery. 2022 Jul 29;8(1):342.
4. Chen Y*, Zhao Y, Mishra PK. Editorial: Autophagy-Mediated Cell Survival and Death in Disease Progression and Treatment. Frontiers in Cell and Developmental Biology. 2022 Jul 4;10:916347
5. Chen J, Li Z, Jia X, Song W, Wu H, Zhu H, Xuan Z, Du Y, Zhu X, Song G, Dong H, Bian S, Wang S, Zhao Y, Xie H, Zheng S, Song P. Targeting anillin inhibits tumorigenesis and tumor growth in hepatocellular carcinoma via impairing cytokinesis fidelity. Oncogene. 2022 May;41(22):3118-3130
6. Zhu X#, Song G#, Zhang S#, Chen J, Hu X, Zhu H, Jia X, Li Z, Song W, Chen J, Jin C, Zhou M, Zhao Y, Xie H, Zheng S*, Song P*. Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3. Cancer Research. 2022 Nov 2;82(21):3987-4000.
2021年：
1. Cui D, Qu R, Liu D, Xiong X, Liang T, Zhao Y*. The cross talk between p53 and mTOR pathways in response to physiological and genotoxic stresses. Frontiers in Cell and Developmental Biology. 2021 Nov 18;9:775507
2. Fei X, Li Z, Yang D, Kong X, Lu X, Shen Y, Li X, Xie S, Wang J, Zhao Y, Sun Y, Zhang J, Ye Z, Wang J, Cai Z*. Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles. Journal of Extracellular Vesicles. 2021 Oct;10(12):e12153
3. Zhang F, Zhao Y*, Sun Y*. USP2 is a SKP2 deubiquitylase that stabilizes both SKP2 and its substrates. Journal of Biological Chemistry. 2021 Oct;297(4):101109
4. Gong L#, Shu J#, Chen X, Pan H, Chen G, Bi Y, Cui D, Li X, Liu D, Wang L, Wang Y, Liu P, Xiong X*, Zhao Y*. DEPTOR inhibits lung tumorigenesis by inactivating the EGFR-mTOR signals. Cancer Letters. 2021 Jul 25; 519 (2021): 263-276
5. Bi Y, Cui D, Xiong X, Zhao Y*. The characteristics and roles of β-TrCP1/2 in carcinogenesis. FEBS Journal. 2021 Jun;288(11):3351-3374
6. Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, Xiong X, Zhao Y*. DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. Theranostics. 2021 Apr 19;11(13):6355-6369
7. Bi Y, Gong L, Liu P, Xiong X, Zhao Y*. Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells. Cell Death & Disease. 2021 Apr 14;12(4):397.
8. Klionsky D*, et al, Zhao Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382.
2020年：
1. Cui D#, Dai X#, Gong L, Chen X, Wang L, Xiong X, Zhao Y*. DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity. Cell Death & Disease. 2020 Nov 12;11(11):976.
2. Chen J#, Xuan Z#, Song W, Han W, Chen H, Du Y, Xie H, Zhao Y, Zheng S*, Song P*. EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation. Oncogene. 2021 Jan;40(1):163-176.
3. Cheng J, Lin M, Chu M, Gong L, Bi Y, Zhao Y*. Emerging role of FBXO22 in carcinogenesis. Cell Death Discovery. 2020 Jul 27;6:66
4. Xiong X, Cui D, Bi Y, Sun Y*, Zhao Y*. Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival. FASEB Journal. 2020 Aug 11; 34(10):13419-13429
5. Zhao Y*, Xiong X, Sun Y*. Cullin-RING Ligase 5: Functional characterization and its role in human cancers. Seminars in Cancer Biology. 2020 Dec;67(Pt 2):61-79
6. Shu J, Cui D, Ma Y, Xiong X, Sun Y, Zhao Y*. SCFβ-TrCP-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II. Oncogenesis. 2020 Feb 3;9(2):8.
7. Gong L, Cui D, Xiong X*, Zhao Y*. Targeting Cullin-RING Ubiquitin Ligases and the Applications in PROTACs. Advances in Experimental Medicine and Biology. 2020;1217:317-347.
8. Chen X#, Xiong X#, Cui D#, Yang F, Wei D, Li H, Shu J, Bi Y, Dai X, Gong L, Sun Y, Zhao Y*. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020 Feb;39(7):1557-1571.
9. Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, Zhao Y*. The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth. Cell Death and Differentiation. 2020 Mar;27(3):1119-1133.
10. Cui D#, Xiong X#, Shu J, Dai X, Sun Y, Zhao Y*. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation. Cell Reports. 2020 Jan 14;30(2):497-509.e4.
2019年：
1. Ma Y#, Cui D#, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ*, Zhao Y*. SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Molecular Oncology. 2019 13(2):307-321.
2. Du Y#, Song W#, Chen J, Chen H, Xuan Z, Zhao L, Chen J, Jin C, Zhou M, Tuo B, Zhao Y, Zheng S, Song P*. The potassium channel KCa3.1 promotes cell proliferation by activating SKP2 and metastasis through the EMT pathway in hepatocellular carcinoma. International Journal of Cancer. 2019, 145(2):503-516.
2018年：
1. Xiong X#, Liu X#, Li H, He H, Sun Y*, Zhao Y*. Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis. Cell Death & Disease. 2018, 9(11):1131.
2. Chen X, Cui D, Bi Y, Shu J, Xiong X, Zhao Y*. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. Cell Cycle. 2018, 17(16):2069-2079.
3. Wang J#, Cui D#, Gu S, Chen X, Bi Y, Xiong X, Zhao Y*. Autophagy regulates apoptosis by targeting NOXA for degradation. BBA Molecular Cell Research. 2018, 1865(8):1105-1113.
4. 魏文毅*、孙毅*、曹诚、常智杰、陈策实、陈佺、程金科、冯仁田、高大明、胡荣贵、贾立军、姜天霞、金建平、李汇华、李卫、刘翠华、刘萱、马蕾娜、缪时英、饶枫、商瑜、宋质银、万勇、王恒彬、王平、王占新、吴缅、吴乔、谢旗、谢松波、谢志平、徐平、许执恒、杨波、阳成伟、应美丹、张宏冰、张令强、赵永超、周军、朱军、王琳芳、张宏、王琛、邱小波*. 类泛素蛋白及其中文命名. 科学通报. 2018, 63(25):2564-2569.
5. Chen J, Song W, Du Y, Li Z, Xuan Z, Zhao L, Chen J, Zhao Y, Tuo B, Zheng S*, Song P*. Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation. Biochemical and Biophysical Research Communications. 2018, 499(3):433-440.
6. Gu S, Cui D, Chen X, Xiong X*, Zhao Y*. PROTACs: An emerging targeting technique for protein degradation in drug discovery. Bioessays. 2018, 40(4):e1700247.
7. Zhao Y*, Tan M, Liu X, Xiong X*, Sun Y*. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death & Disease. 2018, 9(2):145.
2017年：
1. Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y*. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications. 2017, 8:14002.
2. Song P#, Du Y#, Song W, Chen H, Xuan Z, Zhao L, Chen J, Chen J, Guo D, Jin C, Zhao Y, Tuo B, Zheng S*. KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma. Journal of Cancer. 2017, 8(9):1568-1578.
2016年：
1. Cui D, Xiong X, Zhao Y*. Cullin-RING ligases in regulation of autophagy. Cell Division. 2016, 11:8.
2. Zhou X#, Tan M#, Nyati M, Zhao Y, Wang G*, Sun Y*. Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2016, 113(21):E2935-44.
3. Klionsky D*, et al, Zhao Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016, 12(1):1-222.
2015年以前：
1. Zhao Y, Morgan M, Sun Y*. Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxidants & Redox Signaling. 2014, 21(17):2383-400.
2. Xiong X#, Zhao Y#, Tang F, Wei D, Wang X, Thomas D, Zheng P, Liu Y, Sun Y*. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. 2014, 3:e02236.
3. Li H, Sun G, Zhao Y, Thomas D, Greenson J, Zalupski M, Ben-Josef E, Sun Y*. DEPTOR has growth suppression activity against pancreatic cancer cells. Oncotarget. 2014, 5(24):12811-9.
4. Zhou W, Xu J, Zhao Y, Sun Y*. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget. 2014, 5:6746-55.
5. Li H#, Tan M#, Jia L, Wei D, Zhao Y, Chen G, Zhao L, Thomas D, Bear D, Sun Y*. Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. Journal of Clinical Investigation. 2014, 124: 835-46.
6. Zhao Y, Sun Y*. The FBW7-KLF2 axis regulates endothelial functions. Cell Research. 2013, 23:741-3.
7. Zhao Y, Sun Y*. Cullin-RING Ligases as attractive anti-cancer targets. Current Pharmaceutical Design. 2013, 19:3215-25.
8. Yang D#, Zhao Y#, Liu J, Sun Y*, Jia L*. Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. Autophagy. 2012, 8: 1856-8.
9. Zhao Y, Xiong X, Jia L, Sun Y*. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease. 2012, 3: e386.
10. Zhao Y, Sun Y*. CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome? Cell Research. 2012, 22:1224–6.
11. Zhao Y, Sun Y*. Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application. Neoplasia. 2012, 14: 360-7.
12. Yang D, Zhao Y, Li A, Wang S, Wang G*, Sun Y*. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast Cancer Research and Treatment, 2012, 133:189-99.
13. Zhao Y, Xiong X, Sun Y*. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell. 2011, 44: 304-16.
14. Tan M#, Zhao Y#, Kim S, Liu M, Jia L, Saunders T, Zhu Y*, Sun Y*. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Developmental Cell. 2011, 21: 1062-76.
15. Xiong X, Zhao Y, He HB, Sun Y*. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene, 2011, 30: 1798–1811.
16. Tan M, Zhu Y, Kovacev J, Zhao Y, Pan Z, Spitz, D, Sun Y*. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells. Free Radical Biology and Medicine, 2010, 49: 976-83.
17. Zhao Y#, Shao W#, Wei H, Qiao J, Lu Y, Sun Y, Mitchelson K, Cheng J, Zhou Y*. Development of a novel oligonucleotide array-based transcription factor assay platform for genome-wide active transcription factor profiling in Saccharomyces cerevisiae. Journal of Proteome Research. 2008, 7: 1315-25.
18. Yang Q#, Zhao Y#, Xiong Q, Cheng J*. Rapid chip-based capillary electrophoretic mobility shift assay with negative pressure injection for the binding study of transcription factor Abf1 in Saccharomyces cerevisiae. Electrophoresis. 2008, 29: 5003-9.
19. Qiao J, Shao W, Wei H, Sun Y, Zhao Y, Xing W, Zhang L, Mitchelson K, Cheng J*. Novel high-throughput profiling of human transcription factors and its use for systematic pathway mapping. Journal of Proteome Research, 2008, 7: 2769-79.
20. Sun Y, Zhang Y, Zeng L, Wu J, Wei L, Ren A, Shao W, Qiao J, Zhao Y, Zhang L, Mitchelson K, Cheng J*. Broad profiling of DNA-binding transcription factor activities improves regulatory network construction in adult mouse tissues. Journal of Proteome Research, 2008, 7: 4455-64.
21. Yin H, Zhao Y, Zhang Y, Zhang H, Xu L, Zou Z, Yang W, Cheng J, Zhou Y*. Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent. Biotechnology Letters, 2006, 28:99-105.
22. Yin H, Xu H, Zhao Y, Yang W, Cheng J, Zhou Y*. Cyclooxygenase- independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays. Biotechnology Letters, 2006, 28:1263-70.
23. Shao W, Wei H, Qiao J, Zhao Y, Sun Y, Zhou Y, Cheng J*. Parallel profiling of active transcription factors using an oligonucleotide array-based transcription factor assay (OATFA). Journal of Proteome Research, 2005, 4:1451-6.
