许大千实验室
许大千
研究员,博士生导师
研究领域:肿瘤代谢,生物化学,分子生物学
许大千

代表性论著

1.Wang L*, Shi R*, Wang S*, Duan Y*, Wang Z*, Zheng P, Sun X, Chen X, Ji G, Shen Y, Dong B, Lin Y, Wen T, Tian Q, Guo Z, Hou Y, Wu S, Xiao L, Li M, Xiao LW, Wu Q, Meng Y, Liu G, Duan S, Bai X, Liu T, Zhang Z, Zhan P, Lu Z, and Xu D#. ADSL promotes autophagy and liver tumor growth through fumarate-mediated Beclin1 dimethylation. Nature Chemical Biology. in press. (*co-first author, #corresponding author)(唯一通讯)

2.Wu K*, Yan M*, Liu T*, Wang Z*, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q#, Lu Z# and Xu D#. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nature Cell Biology. (2023) May;25(5):714-725. (*co-first author, #co-corresponding author)(最后通讯)

3.Liu T*, Wang Z*, Ye L*, Duan Y*, Jiang H, He H, Xiao L, Wu Q, Xia Y, Yang M, Wu K, Yan M, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Shao F, Qian X, Yu R, Zhang Z, Lu Z# and Xu D#. Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. Nature Cell Biology. (2023) Feb;25(2):273-284. (*co-first author, #co-corresponding author) (最后通讯)

4.Wang Z*, Yan M*, Ye L*, Zhou Q*, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B#, Lu Z# and Xu D#. VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation. The EMBO Journal. (2024) Mar;43(6):931-955.(*co-first author, #co-corresponding author) (最后通讯)

5.Meng Y*, Guo D*, Lin L*, Zhao H, Xu W, Luo S, Jiang X, Li S, He X, Zhu R, Shi R, Xiao L, Wu Q, He H, Tao J, Jiang H, Wang Z, Yao P, Xu D#, Lu Z#. Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance β-oxidation and tumor cell proliferation. Nature Metabolism. 2024 Jun;6(6):1092-1107. 共同通讯)

6.Li M*, Wang Z*, Tao J*, Jiang H, Yang H, Guo D, Zhao H, He X, Luo S, Jiang X, Yuan L, Xiao L, He H, Yu R, Fang J, Liang T, Mao Z, Xu D# and Lu Z#. Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. Nature Chemical Biology. (2024) Mar; Online ahead of print. (*co-first author, #co-corresponding author) (共同通讯)

7.Wang Z, Ma L, Meng Y, Fang J#, Xu D#, Lu Z#. The interplay of the circadian clock and metabolic tumorigenesis. Trends in Cell Biology. (2024)Sep;34(9):742-755.  (#co-corresponding author)(共同通讯)

8.Wang Z*, Li M*, Jiang H, Luo S, Shao F, Xia Y, Yang M, Ren X, Liu T, Yan M, Qian X, He H, Guo D, Duan Y, Wu K, Wang L, Ji G, Shen Y, Li L, Zheng P, Dong B, Fang J, Zheng M, Liang T, Li H, Yu R, Xu D# and Lu Z#. Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth. Nature Cell Biology. (2022) Nov;24(11):1655-1665. (*co-first author, #co-corresponding author) (共同通讯)

9.Xu D*, Shao F*, Bian X*, Meng Y, Liang T and Lu Z. The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies. Cell Metabolism. (2021) Jan 5;33(1):33-50.(*co-first author) (第一作者)

10.Bian X*, Liu R*, Meng Y*, Xing D#, Xu D# and Lu Z#. Lipid metabolism and cancer. Journal of Experimental Medicine. (2021) Jan 4;218(1):e20201606. (*co-first author, #co-corresponding author) (共同通讯)

11.Xu D*#, Wang Z*, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung MC# and Lu Z#. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. (2020) Apr;580(7804):530-535. (*co-first author, #co-corresponding author) (第一作者兼共同通讯)

12.Jiang H*, Zhu L*, Xu D# and Lu Z#. A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis. Cancer Communications. (2020) Sep;40(9):389-394. (*co-first author, #co-corresponding author) (共同通讯)

13.Xu D, Li X, Shao F, Lv G, Lv H, Lee JH, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H#, Lyu J# and Lu Z#. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Science Advances. (2019) Apr 24;5(4):eaav4570. (#co-corresponding author) (第一作者)


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