论著（期刊论文；*: 通讯作者）
1. Feng Y-L*, Wang M, Li G, Chen R-D, Yao R, Dong S-L, Cai1 X-J*, Xie A-Y*. 53BP1-independent Shieldin-BRCA1 antagonism at replication-coupled double-strand breaks. Nat Commun 2026; 17(1):8126.
2. Li G, Huang Z-C, Chen R-D, Yao R, Xie A-Y*, Feng Y-L*. Genomic instability and related immunity in BRCA1/2-deficient cancers: a narrative review. Breast Commun 2026; 2:5.
3. Dong M, He D, Zhang J, Yan H, Chen H, Zhang E, Feng Y, He J, Huang X, Chen G, Sun X, Cheng F, Gu H, Xu R, Guo X, Chen J, Wang H, Xie A*, Cai Z*. Macrophages promote aberrant DNA repair in multiple myeloma via the CXCL5/CXCR2 axis. Haematologica 2026; 111(1):271-285.
4. Huang Z-C, Feng Y-L, Liu Q, Chen R-D, Liu S-C, Wang M, Xie A-Y*. Late steps of allelic break-induced replication suppress tandem duplication associated with BRCA1 deficiency. Nucleic Acids Res 2025; 53(14):gkaf729.
5. Chen R-D, Yang Y, Liu K-M, Hu J-Z, Feng Y-L, Yang C-Y, Jiang R-R, Liu S-C, Wang Y, Han P-A, Tian R-G, Wang Y-L, Xu S-M*, Xie A-Y*. Post-cleavage target residence determines asymmetry in non-homologous end joining of Cas12a-induced DNA double strand breaks. Genome Biol 2025; 26:96.
6. 冯依力*, 陈若丹, 谢安勇*. “藕断丝连”的CRISPR/Cas：基因编辑中靶点滞留的作用与挑战. 生物化学与生物物理进展 2024; 51(10):2621-2636.
7. Zhang J-N, Dong M-M, Cao W, Chen H-G, Gu H-Y, Feng Y-L, Zhang E-F, He J-S, Liu S-C, Xie A-Y*, Cai Z. Disruption of DNA-PKcs-mediated cGAS retention on damaged chromatin potentiates DNA damage-inducing agent-induced anti-multiple myeloma activity. Brit J Cancer 2024; 131:430-443.
8. Wang Y, Feng Y-L, Liu Q, Xiao J-J, Liu S-C, Huang Z-C, Xie A-Y*. TREX2 enables efficient genome disruption mediated by paired CRISPR/Cas9 nickases that generate 3'-overhanging ends. Mol Ther Nucleic Acids 2023; 34:102072.
9. Guo T, Chen G-Q, Li X-F, Wang M, Liu Q-M, Yang X-Y, Liu S-C, Feng Y-L, Liu P-Y*, Lin H*, Xie A-Y*. Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9. Genome Med 2023;15:80.
10. Feng Y-L, Liu S-C, Chen R-D, Sun X-N, Xiao J-J, Xiang J-F, Xie A-Y*. Proximal binding of dCas9 at a DNA double strand break stimulates homology-directed repair as a local inhibitor of classical non-homologous end joining. Nucleic Acids Res 2023;51(6):2740-2758.
11. Liu S-C, Feng Y-L, Sun X-N, Chen R-D, Liu Q, Xiao J-J, Zhang J-N, Huang Z-C, Xiang J-F, Chen G-Q, Yang Y, Lou C, Li H-D, Cai Z, Xu S-M, Lin H, Xie A-Y*. Target residence of Cas9-sgRNA influences DNA double-strand break repair pathway choices in CRISPR/Cas9 genome editing. Genome Biol 2022; 23:165.
12. Feng Y-L*, Liu Q, Chen R-D, Liu S-C, Huang Z-C, Liu K-M, Yang X-Y, Xie A-Y*. DNA nicks induce mutational signatures associated with BRCA1 deficiency. Nat Commun 2022; 13:4285.
13. Feng Y-L*, Wang M, Xie A-Y*. Target residence of Cas9: challenges and opportunities in genome editing. Genome Instab Dis 2022: 3:7-69.
14. Feng Y-L*, Liu S-C, Chen R-D, Xie A-Y*. Target binding and residence: a new determinant of DNA double strand break repair pathway choice in CRISPR/Cas9 genome editing. J Zhejiang Univ SCIENCE B 2021; 22(1):73-86.
15. Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z, Pu WT, Chen S, Chen Y, Sun K, Ge B, Zhang B. LARP7 Is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis. Cell Rep 2020; 32(4):107974.
16. Kong N, Ji X, Wang J, Sun X, Chen G, Fan T, Liang W, Zhang H, Xie A*, Farokhzad OC, Tao W*. ROS-mediated selective killing effect of black phosphorus: mechanistic understanding and its guidance for safe biomedical applications. Nano Letters 2020; 20(5):3943-3955.
17. Guo T, Feng Y-L, Xiao J-J, Liu Q, Sun X-N, Xiang J-F, Kong N, Liu S-C, Chen G-Q, Wang Y, Dong M-M, Cai Z, Lin H, Cai X-J*, Xie A-Y*. Harnessing accurate non-homologous end joining for efficient precise deletion in CRISPR/Cas9-mediated genome editing. Genome Biol 2018; 19:170.
18. Xie X, Hu H, Tong X, Li L, Liu X, Chen M, Yuan H, Xie X, Li Q, Zhang Y, Ouyang H, Wei M, Huang J, Liu P, Gan W, Liu Y, Xie A, Kuai X, Chirn GW, Zhou H, Zeng R, Hu R, Qin J, Meng FL, Wei W, Ji H, Gao D*. The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168. Nat Cell Biol 2018; 20:320-331.
19. Han J, Ruan C, Huen M, Wang J, Xie A, Fu C, Liu T, Huang J*. BRCA2 antagonizes 53BP1/RIF1/Artemis-dependent classical and alternative nonhomologous end-joining to prevent gross genomic instability. Nat Commun 2017; 8:1470.
20. Feng Y-L, Xiang J-F, Liu S-C, Guo T, Yan G-F, Feng Y, Kong N, Li H-D, Huang Y, Lin H, Cai X-J*, Xie A-Y*. H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic Acids Res 2017; 45:10614-10633.
21. Guirouilh-Barbat J, Gelot C, Xie A, Dardillac E, Scully R, Lopez BS*. 53BP1 protects against CtIP-dependent capture of ectopic chromosomal sequences at the junction of distant double strand breaks. PLOS Genet 2016; 12:e1006230.
22. Tang J-C, Feng Y-L, Guo T, Xie A-Y*, Cai X-J*. Circulating tumor DNA in hepatocellular carcinoma: trends and challenges. Cell Biosci 2016; 6:32.
23. Feng Y-L, Xiang J-F, Kong N, Cai X-J*, Xie A-Y*. Buried territories: heterochromatic response to DNA double strand breaks. Acta Biochim Biophys Sin 2016; 48:594-602.
24. Chen J, Ji T, Zhao J, Li G, Zhang J, Jin R, Liu J, Liu X, Liang X, Huang D, Xie A, Lin H*, Cang Y*, Cai X*. Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint. Oncotarget 2016. 7:41274-41284.
25. Liu J, Li J, Fu W, Tang J, Feng X, Chen J, Liang Y, Jin R, Xie A, Cai X*. Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation. Drug Des Devel Ther 2015; 9:5655-67.
26. Liu X-S, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R*, Lunardi A*, Pandolfi PP*. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun 2015; 6:8325.
27. Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W*. Akt-mediated phosphorylation of XLF impairs non-homologous end joining DNA repair. Mol Cell 2015; 57:648–661.
28. Tang J-C, Xie A-Y, Cai X-J*. Diverse functions of fibulin-5 in tumor. Mol Biol 2014; 48:761-766.
29. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM*. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov 2014; 4:1430-1447.
30. Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R*. BRCA1 and CtIP suppress long tract gene conversion between sister chromatids. Nat Commun 2013; 4:2404.
31. Rass E, Chandramouly G, Zha S, Alt FW, Xie A*. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem 2013; 288:7086-7095.
32. Scully R* and Xie A. Double strand break repair functions of histone H2AX. Mutat Res 2013; 750:5-14.
33. Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R*. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One 2012; 7:e49211.
34. Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC*. Nek4 regulates entry into replicative senescence and the response to DNA-damage in human fibroblasts. Mol Cell Biol 2012; 32:3963-3977.
35. Hu Y, Scully R, Sobhian B, Xie A, Shestokova E, Livingston DM*. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev 2011; 25:685-700.
36. Xie A, Odate S, Chandramouly G, Scully R*. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle 2010; 9:3602-3610.
37. Xie A*, Kwok A, Scully R*. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 2009; 16:814-818.
38. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R*. Distinct roles of chromatin-associated factors MDC1 and 53BP1 in mammalian double strand break repair. Mol Cell 2007; 28:1045-1057.
39. Xie A and Scully R*. Hijacking the DNA damage response to enhance viral replication: γ-Herpesvirus 68 orf36 phosphorylates histone H2AX. Mol Cell 2007; 27:178-179.
40. Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol 2006; 26:8075-8086.
41. Scully R* and Xie A. In my end is my beginning: control of end resection and DSBR pathway “choice” by cyclin-dependent kinases. Oncogene 2005; 24:2871-2876.
42. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R*. Control of sister chromatid recombination by histone H2AX. Mol Cell 2004; 16:1017-1025.
43. Scully R* and Xie A. BRCA1 and BRCA2 in breast cancer predisposition and recombination control. J Mammary Gland Biol Neoplasia 2004; 9:237-246.
44. Scully R*, Xie A, Nagaraju G.Molecular functions of BRCA1 in the DNA damage response. Cancer Biol Ther 2004; 3:521-527.
45. Xie A-Y and Folk WR*. Inhibition of polyomavirus ori-dependent DNA replication by mSin3B. J Virol 2002; 76:11809-11818.
46. Xie A-Y, Bermudez VP, Folk WR*. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: Acetylation of large T antigen. Mol Cell Biol 2002; 22:7907-7918.
47. Berjanskii MV, Riley MI, Xie A, Semenchenko V, Folk WR, Van Doren, SR*. NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens. J Biol Chem 2000; 275:36094-36103.
48. Yong W-D, Liang T-B, Xie A-Y, Li C, Song Y-R*. PhbB, phbC gene expression in E. coli and their transformation and identification in potato. Acta Botanica Sinica 1998; 40:615-621.
49. Xie A-Y, Cui X-J, Song Y-R*. Cloning and sequencing of Alcaligenes eutrophus H16 phbB and phbC genes and construction of their plant expression vectors. Acta Botanica Sinica 1995; 37:581-588.
50. Song Y-R* and Xie A-Y. Biosynthesis of ethylene and molecular regulation of fruit maturation. Acta Botanica Sinica 1994; 36 (SUPPL.):1-13.
51. Xie A-Y and Song Y-R*. Applications of biotechnology in producing biodegradable plastic PHB. Chinese Bulletin Bot 1994; 11:21-25.
