陈静海实验室
陈静海
研究员, 博士生导师
研究领域:
非编码核酸对心脏发育与心脏再生的调控研究、
非编码核酸在心血管重构中的作用机制研究、
心脏代谢与稳态平衡
陈静海

代表性论著

(1) Liu N#, Kataoka M#, Wang Y#, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J*, Wang DZ*, Chen J*. LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Basic Research in Cardiology. 2021 Aug 11;116(1):48.  (2020 IF= 17.165)

(2) Liang T#, Gao F#, Jiang J#, Lu YW, Zhang F, Wang Y, Liu N, Fu Y, Dong Y, Pei J, Cowan, D, Hu X, Wang J*, Wang DZ*, Chen J*. Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction. Circulation. 2020 Dec;142(22):2196-2199.  (2020 IF=29.690)

(3) Zhang F#, Fu X#, Kataoka M, Liu N, Wang Y, Gao F, Liang T, Dong X, Pei J, Hu X, Zhu W, Yu H, Cowan DB, Hu X, Huang ZP, Wang J*, Wang DZ*, Chen J*. Long noncoding RNA Cfast regulates cardiac fibrosis. Molecular Therapy Nucleic Acid. 2021 Mar 5, 23:377-392. (2020 IF=8.886) 

(4) Liang T, Gao F, Chen J*. Role of PTEN-less in cardiac injury, hypertrophy and regeneration.  Cell Regeneration. 2021 Aug 2;10(1):25. (Invited review) 

(5) Dong X, Dong X, Gao F, Liu N, Liang T, Zhang F, Fu X, Pu L, Chen J*. Non-coding RNAs in cardiomyocyte proliferation and cardiac regeneration: Dissecting their therapeutic values. J Cell Mol Med. 2021 Mar;25(5):2315-2332

(6) Wang F, Liu S, Pei J, Cai L, Liu N, Liang T, Dong X, Cong X, Chun J, Chen J*, Hu S*, Chen X*. LPA3-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice. Theranostics. 2020; 10(24): 10892-10907.  (2020 =11.556)                  

(7) Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu WT, Wang J, Chen J*, Wang DZ*. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction.Nature Communications. 2019;10(1):1802                     

(8) Seok H#, Chen J#, Kataoka M, Huang ZP, Ding J, Yan J, Hu X, Wang DZ*. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circulation Research. 2014;114(10):1585-95.                                   

(9) Chen J, Huang ZP, Seok H, Ding J, Kataoka M, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu W, Liao R, Wang DZ*. mir-17-92 Cluster is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts. Circulation Research. 2013; 112(12):1557-66.   (Sci高被引用论文)

(10) Huang ZP#, Chen J#, Seok H, Zhang Z, Kataoka M, Hu X, Wang DZ. MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress. Circulation Research. 2013 112(9):1234-43. (Sci高被引用论文)     

(11) Chen J, Wang DZ*. microRNAs in cardiovascular development. J Mol Cell Cardiol. 2012; 52(5): 949-57. (Invited review)

(12) Chen J, Shearer GC, Chen Q, Healy CL, Beyer AJ, Nareddy VB, Gerdes AM, Harris WS, O'Connell TD, Wang D*. Omega-3 Fatty Acids Prevent Pressure Overload-Induced Cardiac Fibrosis Through Activation of Cyclic GMP/Protein Kinase G Signaling in Cardiac Fibroblasts. Circulation. 2011;123(6):584-93

(13) Chen J, Ortmeier SB, Savinova OV, Nareddy VB, Beyer AJ, Wang D, Gerdes AM*. Thyroid hormone induces sprouting angiogenesis in adult heart of hypothyroid mice through the PDGF-Akt pathway. J Cell Mol Med. 2012 16(11):2726-35.     

(14) Chen J, Baydoun AR, Xu R, Deng L, Zhu W, Cong X, Hu S, Chen X*. Lysophosphatidic Acid Protects Mesenchymal Stem Cells against Hypoxia and Serum Deprivation-Induced Apoptosis. Stem Cells. 2008;26(1):135-45. 

(15) Chen J, Chen Y, Zhu W, Han Y, Han B, Xu R, Deng L, Cai Y, Cong X, Yang Y, Hu S, Chen Xi*. Specific LPA receptor subtype mediation of LPA-induced hypertrophy of cardiac myocytes and involvement of Akt and NFkappaB signal pathways. J Cell Biochem. 2008;103(6):1718-31. 

(16) Chen J, Han Y, Zhu W, Ma R, Han B, Cong X, Hu S, Chen X*. Specific receptor subtype mediation of LPA-induced dual effects in cardiac fibroblasts. FEBS Letters.  2006;580(19):4737-45.                               

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