Selected publications since 2018 (out of a total of 97):
1. Zhou, W., Xu, J., Tan, M., Zhang, J., Li, H., Li, H., Wei, W., Sun, Y.: UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F. Mol Cell 70: 1008–1024, 2018.
2. Yang, F., Xu, J., Li, H., Tan, M., Xiong, X., and Sun, Y.: FBXW2 suppresses migration and invasion of lung cancer cells via promoting ubiquitylation and degradation of β-catenin. Nat. Communications, 2019 March 27, 10:1382 | https://doi.org/10.1038/s41467-019-09289-5.
3. Lan, H., Tan, M., Zhang, Q., Li, H., Xiong, X. and Sun, Y.: LSD1 destabilizes FBXW7 and inhibits FBXW7 activity independent of its demethylase activity. Proc Natl Acad Sci USA 116: 12311-12320, 2019. PMID: 31152129.
4. Yin, Y., Xie, C., Li, H., Tan, M., Chen, G., Schiff, R., Xiong, X., and Sun, Y.: The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc. Natl. Acad Sci USA. 116:20528-20538, 2019. doi: 10.1073/pnas.1905973116. PMID 31548378
5. Zhang, S., Shen, Y., Li, H., Bi, C., Sun, Y., Xiong, X., Wei, W., and Sun, Y.: The negative cross-talk between SAG and APC/C E3s in regulation of cell cycle and drug resistance. Cell Reports. 32, 108102, Sept. 8, 2020. https://doi.org/10.1016/j.celrep.2020.108102
6. Wu, D., Li, H., Liu, M., Qin, J. and Sun, Y.: Ube2m-Rbx1 neddylation-Cullin Ring E3 Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Nature Communs. 2022, May 31, 13:3021 https://doi.org/10.1038/s41467-022-30707-8
7. Zhou, Q., Lin, W., Wang, C., Sun, F., Ju, S., Wang, Y., Chen, Y., Chen, Q., Li, H., Wang, L., Hu, Z., Jin, H., Wang, X.*, and Sun, Y.*: Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells. Nature Communs. 2022, May 31, 13:3034 https://doi.org/10.1038/s41467-022-30559-2
8. Xu, T., Ma, Q., Li, Y., Yu, Q., Pan, P., Zheng, Y., Li, Z., Xiong, X., Hou, T., Yu, B., Liu, H., and Sun., Y.: A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer. Signal Transduction Targeted Ther. 2022 Oct 17;7(1):354. doi: 10.1038/s41392-022-01182-w. 7:4208-4222, 2022.
9. Tan, M., Chang, Y., Li, H., Tang, Z., Nyati, M., and Sun, Y.: The Sag/Rbx2-Shoc2 axis regulates the conversion of mPanINs to neoplastic cystic lesions in the Kras pancreatic tumor model. Cell Reports, 2022 Dec 20;41(12):111837. doi: 10.1016/j.celrep.2022.111837.
10. Zhang, S., You, X., Zheng, Y., Sheng, Y., Xiong, X., and Sun, Y.: The UBE2C/CDH1/DEPTOR axis is an oncogene-tumor suppressor cascade in lung cancer cells. J Clin Invest. 2023 Feb 15;133(4):e162434. doi: 10.1172/JCI162434.
11. Li, Y., Zhou, H., Liu, P., Lv, D., Tang, B., Xu, W., Zhang, J., Xu, J., Zhou, J., Ying, K., Zhao, Y., Sun, Y., Jiang, Z., Cheng, H., Zhang, X., and Ke, Y.: SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47-SIRPα axis. J Clin Invest., 2023 Feb 15;133(4):e162870. doi: 10.1172/JCI162870.
12. Liang, X., Yao, J., Cui, D., Zheng, W., Liu, Y., Lou, G., Ye, B., Shui, L., Sun, Y., Zhao, Y., and Zheng, M.: The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. Cell Death Differ 30:1550-1562, 2023. doi: 10.1038/s41418-023-01164-7.
13. Lu, X., Kong, X., Chen, J., Ma, Z., Shen, Y., Zeng, X., Fei, X., Wang, S., Sun, Y., Li, X., Jiang, L., Gu, Z., Yang, F., Wang, J., Cai, Z.: UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders. Cell Metabolism, 2023 Jun 14; S1550-4131(23)00209-7. doi: 10.1016/j.cmet.2023.05.011.
14. Wu, D., and Sun, Y.: The functional redundancy of neddylation E2s and E3s in modulating the fitness of regulatory T cells. Research, Aug 03, 2023. https://spj.science.org/doi/abs/10.34133/research.0212.
15. Mao, H, Lin, X., and Sun, Y.: Neddylation regulation of immune responses. Research 2023;6: Article 0283. https://doi.org/10.34133/ research.0283
16. Wang, W, Li, E., Zou, J., Qu., C., Ayala, J., Wen, Y., Islam, M.S., Weintraub, N. L., Fulton, D. J., Liang, Q, Zhou, J., Liu, J., Li, J., Sun, Y., and, Su, H.: The ubiquitin ligase RBX2/SAG regulates mitochondrial ubiquitination and mitophagy. Circulation Res. 2024 Jun 14. doi: 10.1161/CIRCRESAHA.124.324285.
17. Zhang, Y., Du, L.-J., Wang, C., Jiang, Z., Duan, Q., Li, Y., Xie, Z., He, Z., Sun Y., Huang, L., Lu, L., and Wen, C. Targeting neddylation pathway is a novel therapeutic strategy for lupus by regulating double negative T cell homeostasis. Signal Transduction Targeted Ther. 2024 Jan 15;9(1):18. doi: 10.1038/s41392-023-01709-9.
18. Chang, Y., Chen, Q., Li, H., Xu, J., Tan, M., Yang, F., Xiong, X., and Sun, Y.: The UBE2F-CRL5Asb11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells. Dev Cell, 59: 1317–1332, May 20, 2024 https://doi.org/10.1016/j.devcel.2024.03.018
19. Zhang, S. Yu, Q., Li, Z., Zhao, Y., and Sun, Y.: Neddylation pathway and its role in health and diseases. Signal Transdust Targeted Ther. 9:1869-1904, 2024. 2024 Apr 5;9(1):85. doi: 10.1038/s41392-024-01800-9.
20. Zhou, Q#., Yu, H#., Chen, Y., Ren, J., Lu, Y., and Sun, Y.: The CRL3KCTD10 ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11. PNAS, 2024 Jul 9;121(28):e2320655121. doi: 10.1073/pnas.2320655121
21. Zhou, Q., Li, Z., and Sun, Y.: CRL3 E3 ligase regulates glutamine and cystine metabolisms. Protein & Cell, 2024 Sep 13: pwae051. doi: 10.1093/procel/pwae051, 2024, 15: 867-871.
22. Xiong, X., Zhao, Y., and Sun, Y.: SMURF1: A promising target for colon cancer therapy. Protein & Cell, 2024 Sep 27: pwae053. https://doi.org/10.1093/procel/pwae053
23. Zhang, F. Wang, H., Xiong, X., Zhao, Y., and Sun, Y.: RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis. EMBO J., 2025 Jan 6.doi: 10.1038/s44318-024-00353-5. 44: 1185-1219, 2025.
24. Cui, D., Shao, S., Qu, R., Chen, X., Jiang, S., Wang, L., Gong, L., Li, T., Song, W., Song, P., Sun, Y., Liang, T., Xiong, X., and Zhao, Y. The FBXW7-RPAP2 axis controls the growth of liver cancer cells and determines the fate of liver cell differentiation. Adv. Sci., 2025 Feb 11: e2404718. doi: 10.1002/advs.202404718. Online ahead of print.
25. Xiong, X., Chen, X., Shao, S., Cui, D., Wang, B., Sun, Y., Zhao, Y.: DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase. Cell Death Diff. 2025 Oct;32(10):1820-1832. doi: 10.1038/s41418-025-01497-5.
26. Yin, L., Zhang, J., Zhu, Z., Peng, X., Lan, H., Ayoub, A., Tan, M., Zhou, B., He, Y., Wang, S., Lu, Y., Liu, W., Xiong, X., Huang, J., Dou, Y., Mao, F., and Sun, Y.: The FBXW7-KMT2 axis in cancer-associated fibroblasts control the tumor growth via an epigenetic-paracrine mechanism. PNAS, 2025 Apr;122(13):e2423130122. doi: 10.1073/pnas.2423130122.
27. Gu., L., Shen, Z., Shen, S., Wang, C., Liu, Y., Wei, X., Zheng, M., Gu, J., Chen, X., Sun, Y., Xu, J., Lu, Y., and Lu, W.: The INAVA mRNA in extracellular vesicles activates normal ovarian fibroblasts by phosphorylation–ubiquitylation crosstalk of HMGA2. Adv. Science,https://doi.org/10.1002/advs.202500912.
28. Nikolic, I., Cursons, J., Shields, B., Chappaz, S., Sudholz, H., Meng, X., Constantinescu, P., Vijayakumaran, R., D’Angelo, M., Foroutan, M., Ladd, D., Veldman, M., Glab, J., Procter, T., Park, H.-Y., Contet, J., Deuss, F., Wong, K., Sun, Y., Berry, R., Rautela, J., and Huntington, N.: UBE2F inhibits natural killer cell anti-tumor immunity by activating the ARIH2-CRL5 complex to degrade IL-15 receptors. Cancer Cell. 2025 Jun 10: S1535-6108(25)00220-X. doi: 10.1016/j.ccell.2025.05.011. Online ahead of print.
29. Wu, D., Chen, Q., Tan, M., and Sun, Y.: E3 ligase Rbx1 orchestrates thymus development and fate determination of αβ-γδ T cells. Research, https://doi. org/10.34133/research.0774
30. Wu, X., Li, S., Liang, T., Yu, Q., Zhang, Y., Liu, J., Li, K., Liu, Z., Cui, M., Zhao, Y., Han, X., Jin, R., Tan, M., Chen, X., Zhao, Y., Zheng, M., Sun, Y., * Zhou, L., *, and Lu, X. * Proteome-wide data guides the discovery of lysine-targeting covalent inhibitors using DNA-encoded chemical libraries. Angewandte Chemie. Int. Ed. 2025, e202505581doi.org/ 10.1002/anie.202505581. (*Co-corresponding authors).
31. Zhou, Q#., Yu, H#., Dong, A., Li, J., Qiu, Q., Li, X., Lu, B., Sun, Y.*, Liu, P.*, and Lu, Y.*: The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells. Neoplasia, https://doi.org/10.1016/j.neo.2025.101211 (*co-corresponding authors).
32. Wang, L., Chen, X., Qu, R., Shao, S., Gong, L., Li, T., Jiang, S., Lu, Y., Ma, Y., Sun, Y., Cui, D., Xiong, X., and Zhao, Y.: UBE2C promotes pancreatic tumorigenesis by KRAS stabilization via APC/CCDH1-mediated WRD76 degradation. Cancer Lett. 2025 Aug 30:633:218013. doi: 10.1016/j.canlet.2025.218013.
33. Cui, D., Qu, R., Wang, L., Liang, X., Xu, J., Sun, Y., Xiong, X., Zhao, Y.: The crosstalk between CRL5 and APC/C E3 ligases regulates metastasis and chemo-sensitivity of cancer cells. Adv. Sci., 2025 Oct 29:e12652. doi: 10.1002/advs.202512652.
34. Yu, H., Zhou, Q., Chen, Y., Fu, T., Xiong, X., Zhu, F., Wang, L., and Sun, Y.: Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis. J. Biol. Chem.https://doi.org/10.1016/j.jbc.2025.110575.
35. Zhuo, J., Zhai, D., Liu, L., Yin, Y., Chen, Q., You, X., Chen, L., Yu, Q., Xiong, X., Sun, Y.*, and Han, X.*: Discovery of LD-110 as a First-in-Class PROTAC Degrader of LSD1 for the Treatment of Esophagus Squamous Cancer. J. Med. Chem, 2025 Oct 23;68(20):21860-21877. doi:10.1021/acs.jmedchem.5c02246.
36. Zhai, D., Zhuo, J., Yin, Y., Li, L., Liang, M., Zhou, X., Liu, L., Chen, L., Xiong, X., Yu, Q., Han, X. and Sun, Y.: LD-110, a novel LSD1 proteolysis targeting chimera degrader, suppresses tumor growth by inducing endoplasmic reticulum stress and apoptosis. Sci Bulletin.https://doi.org/10.1016/j.scib.2025.10.024.
