沈承勇实验室
沈承勇
研究员,博士生导师
研究领域:神经突触及运动神经环路发育成熟的生理机制,
神经突触疾病(如运动神经元病ALS,肌肉萎缩症,额颞痴呆等)病理机制及转化应用
沈承勇

代表性论著

近年代表性论文(#第一作者,*通讯作者)

1. Wang A#, Chen C#, Mei C, Liu S, Xiang C, Fang W, Zhang F, Xu F, Chen S, Zhang Q,  Bai X, Lin A, Neculai D, Xia B, Ye C, Zou J, Liang T, Feng XH, Li X*, and Shen C*, Xu P*. cGAS-STING machinery senses lysosomal dysfunction and drives ubiquitous lysosomal storage disorders. Nat.Cell.Biol 2024 Jan 22

2. Shu X#, Wei C#, Tu WY#, Zhong K, Qi S, Wang A, Bai L, Zhang SX, Luo B, Xu ZZ, Zhang K*, Shen C*. Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. Cell Reports. 2023 Feb 16;42(2):112133.

3. Zhang K#, Wang A#, Zhong K#, Qi S, Wei C, Shu X, Tu WY, Xu W, Xiao Y, Chen A, Bai L, Zhang J, Luo B, Wang W*, Shen C*. UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model. Neuron. 2021 Jun 16;109(12):1949-1962.

4. Chen A, Bai L, Zhong K, Shu X, Wang A, Xiao Y, Zhang K, Shen C*. APC2CDH1 negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7. FASEB.J. 2020 Sep; 34(9):12009-12023.

5. Xiao Y, Zhang J, Shu X, Bai L, Xu W, Wang A, Chen A, Tu WY, Wang J, Zhang K, Luo B*, Shen C*. Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment. Hum.Mol.Genet. 2020 Jul 21; 29(11):1784-1796.

 


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