Xiaoguang Liu Laboratory
Xiaoguang Liu
Research Interests:
Cancer metabolism
Xiaoguang Liu

Selected Publications

1.  Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Billadeau, Junjie Chen, Boyi Gan. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology, 25.3 (2023): 404-414.

2.  Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nature cell biology, 22.4 (2020): 476-486.

3.    Liu X, Zhuang L, Gan B. Disulfidptosis: disulfide stress-induced cell death. Trends in Cell Biology, (2023). doi: 10.1016/j.tcb.2023.07.009.

4.    Liu X, Zhuang L, Gan B. Unleashing ferroptosis for cancer therapy with warfarin. Trends in Endocrinology & Metabolism, (2023). doi: 10.1016/j.tem.2023.08.008.

5.   Liu X, Wei W, Liu Y, Yang X, Wu J, Zhang Y, Zhang Q, Shi T, Du JX, Zhao Y, Lei M, Zhou JQ, Li J, Wong J. MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300. Cell discovery, 3.1 (2017): 1-17.

6.   Wei W*, Liu X*, Chen J*, Gao S, Lu L, Zhang H, Ding G, Wang Z, Chen Z, Shi T, Li J, Yu J, Wong J.. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. Cell Research, 27.7 (2017): 898-915. (*co-first author)

7.   Chauhan AS*, Liu X*, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. STIM2 interacts with AMPK and regulates calcium-induced AMPK activationThe FASEB Journal, 33.2 (2019): 2957-2970. (*co-first author)

8.    Liu X, Koppula P, Olszewski K, Gan B. Thiol profiling in cancer cell lines by HPLC-mass spectrometry. STAR protocols, 2, no. 4 (2021): 100977.

9.   Liu X, Zhang Y, Zhuang L, Olszewski K, Gan B. NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edge sword in cellular redox regulation. Genes & Diseases, (2020).



Institute of Translational Medicine, Zhejiang University
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