1. Zhang S, Shen Y, Li H, Bi C, Sun Y, Xiong X, Wei W, Sun Y*. The negative cross-talk between SAG/RBX2/ROC2 and APC/C E3 ligases in regulation of cell cycle progression and drug resistance. Cell Reports 2020 Sep 8;32(10):108102.
2. Xiong X, Cui D, Bi Y, Sun Y*, Zhao Y*. Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival. FASEB Journal 2020 Aug 11. doi: 10.1096/fj.202000530RRR. Online ahead of print.
3. Zhang S, Xiong X, Sun Y*. Functional characterization of SOX2 as an anticancer target. Signal Transduction and Targeted Therapy 2020 Jul 29;5(1):135.
4. Yu Q, Xiong X, Sun Y*. Targeting Cullin-RING E3 ligases for anti-cancer therapy: efforts on drug discovery. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(1):1-19. [Article in Chinese]
5. Zhao Y*, Xiong X, Sun Y*. Cullin-RING Ligase 5: Functional Characterization and Its Role in Human Cancers. Seminars in Cancer Biology 2020 Apr 22;S1044-579X(20)30085-7.
6. Gong L, Cui D, Xiong X*, Zhao Y*. Targeting Cullin-RING Ubiquitin Ligases and the Applications in PROTACs. Advances in Experimental Medicine and Biology 2020;1217:317-347. (* co-corresponding author)
7. Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, Zhao Y*. The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth. Cell Death & Differentiation 2020 Mar;27(3):1119-1133.
8. Chen X#, Xiong X#, Cui D#, Yang F, Wei D, Li H, Shu J, Bi Y, Dai X, Gong L, Sun Y, Zhao Y*. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via inactivation of mTORC1/2 signals. Oncogene 2020 Feb;39(7):1557-1571. (# equal contribution)
9. Shu J, Cui D, Ma Y, Xiong X, Sun Y, Zhao Y*. SCFβ-TrCP-mediated Degradation of TOP2β Promotes Cancer Cell Survival in Response to Chemotherapeutic Drugs Targeting Topoisomerase II. Oncogenesis 2020 Feb 3;9(2):8. doi: 10.1038/s41389-020-0196-1.
10. Cui D#, Xiong X#, Shu, J, Dai X, Sun Y, Zhao Y*. FBXW7 confers radiation survival by targeting p53 for degradation. Cell Reports 2020 Jan 14;30(2):497-509.e4. (# equal contribution)
11. Yin Y, Xie CM, Li H, Tan M, Chen G, Schiff R, Xiong X, Sun Y*. The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc. Natl. Acad. Sci. U S A. 2019 Oct 8;116(41):20528-20538.
12. Lan H, Tan M, Li H, Xiong X, Sun, Y*. LSD1 destabilizes FBXW7 independent of its demethylase activity via promoting FBXW7 self-ubiquitylation for proteasomal and lysosomal degradation. Proc. Natl. Acad. Sci. U S A. 2019 Jun 18;116(25):12311-12320.
13. Yang F, Xu J, Li H, Tan M, Xiong X, Sun Y*. FBXW2 suppresses migration and invasion of lung cancer cells via promoting ubiquitylation and degradation of β-catenin. Nature Communications 2019 Mar 27;10(1):1382.
14. Xie CM, Tan M, Lin XT, Wu D, Jiang Y, Tan Y, Li H, Ma Y, Xiong X, Sun Y*. The FBXW7-SHOC2-Raptor axis controls the cross-talks between the RAS-ERK and mTORC1 signaling pathways. Cell Reports 2019 Mar 12;26(11):3037-3050.e4.
15. Ma Y#, Cui D#, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ*, Zhao Y*. SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Molecular Oncology 2019 Feb;13(2):307-321.
16. Xiong X#, Mathewson ND#, Li H, Tan M, Fujiwara H, Li H, Reddy P*, and Sun Y*. SAG/RBX2 E3 ubiquitin ligase differentially regulates inflammatory responses of myeloid cell subsets. Frontiers in Immunology 2018 Dec;9:2882. (# equal contribution)
17. Xiong X#*, Liu X#, Li H, He H, Sun Y*, Zhao Y*. Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis. Cell Death & Disease 2018 Nov 13;9(11):1131. (# equal contribution; * co-corresponding author)
18. Chen X, Cui D, Bi Y, Shu J, Xiong X, Zhao Y*. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. Cell Cycle 2018;17(16):2069-2079.
19. Wang J, Cui D, Gu S, Chen X, Bi Y, Xiong X, Zhao Y*. Autophagy regulates apoptosis by targeting NOXA for degradation. Biochimica et Biophysica Acta-Molecular Cell Research 2018 May 17;1865(8):1105-1113.
20. Gu S, Cui D, Chen X, Xiong X*, Zhao Y*. PROTACs: An emerging targeting technique for protein degradation in drug discovery. BioEssays 2018 Apr;40(4):e1700247. doi: 10.1002/bies.201700247. (* co-corresponding author)
21. Zhao Y*, Tan M, Liu X, Xiong X*, Sun Y*. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death & Disease 2018 Feb 2;9(2):145.
22. Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y*. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications 2017 Jan 16; 8:14002.
23. Xu X, Xiong X*, Sun Y*. The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity. Science China Life Sciences 2016 Jul;59(7):656-672. (* co-corresponding author)
24. Cui D, Xiong X, Zhao Y*. Cullin-RING ligases in regulation of autophagy. Cell Division 2016 Jun 10;11:8.
25. Xiong X#, Zhao Y#, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y*. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. 2014, Aug 21: e02236. doi: 10.7554/eLife.02236. (#equal contribution)
Recommended by Faculty of 1000 as being of special significance in its field (http://f1000.com/prime/718539829?subscriptioncode=7465b73f-8aa5-47a9-972e-39e4ef0a4a69)
26. Zhao Y, Xiong X, Jia L, Sun Y*. Targeting Cullin-RING ligases by MLN4924 induces autophagy by modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease. 2012 Sep 6; 3: e386.
27. Xiong X, Zhao Y, He H, Sun Y*. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene 2011 Apr 14;30(15) :1798-1811.
28. Zhao Y, Xiong X, Sun Y*. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCFβTrCP E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell 2011 Oct 21;44(2): 304-316.
Research Highlight by Katharine H. Wrighton. “Cell signaling: mTOR targets its own inhibitor” Nature Reviews Molecular Cell Biology 2011, 12: 769.
29. Jia L, Yang J, Hao X, Xiong X, Zheng M, He HB, Xu L, Sun Y*. Validation of SAG/RBX2/ ROC2 E3 ubiquitin ligase as an anti-cancer and radio-sensitizing target. Clinical Cancer Research 2010 Feb 1;16(3):814-824.
30. Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y*. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research 2009 Aug 15;69(16): 6556-6564.
31. Liu XM, Xiong XF, Song Y, Tang RJ, Liang XQ*, Cao EH*. Possible roles of a tumor suppressor gene PIG11 in hepatocarcinogenesis and As2O3-induced apoptosis in liver cancer cells. Journal of Gastroenterology 2009, 44(5):460-469.
32. Xiong XF, Li H, Cao EH*. PIG11 protein binds to DNA in sequence -independent manner in vitro. Biochemical and Biophysical Research Communications 2007 Jun 22;358(1):29-34.
