Bo Shan Laboratory
Bo Shan
Researcher, Doctoral Supervisor
Bo Shan

Selected Publications

1. Shan B.*, Shao M.*, Zhang Q., Hepler C., Paschoal V., Barnes S., Vishvanath L., An Y., Malladi V., Strand D., Gupta O., Oh D., and Gupta R.K. (2020) Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity. Nature Metabolism. 2(11):1332-1349. (Highlighted in Nature Review Endocrinology).

2. Shan B.*, Wang X.*, Wu Y.*, Xu C., Xia ZX., Shao M., Zhao F., Liu Y., Nan F., Li J., Rui L., Duan S. and Liu Y. (2017) The Metabolic ER stress sensor IRE1 suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nature Immunology 18(5):519-529. (Previewed by Gökhan S.Hotamisligil in Molecular Cell and Fabio Martinon in Nature Immunology; Highlighted in Nature Review Endocrinology and Nature Review Immunology)

3. Shan B.*, Shao M.*, Zhang Q., An Y., Vishvanath L., and Gupta R.K. (2021) Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual. Genes & Development. 35(19-20):1333-1338. (Cover story. Previewed by Stephen Farmer in Genes Dev.).

4.  Shan B., Barker, C., Shao M., Zhang, Q., Gupta R.K.and Wu Y. (2022) A multi-omics view on stromal cell heterogeneity. Cell Metabolism. (In press)

5.  Wu Y.*, Shan B.*, Dai J., Xia Z., Cai J., Chen T., Lv S., Feng Y., Zheng L., Wang Y., Liu J., Xie D., Rui L., Liu J. and Liu Y. (2018) Dual role for Inositol-requiring Enzyme 1 in promoting the development of hepatocellular carcinoma during diet-induced obesity. Hepatology 68(2):533-546. (*Co-first author).

6.  Shao M.*, Shan B.*, Deng Y., Liu Y., Yan C., Wu Y., Mao T., Qiu Y., Zhou Y., Jiang S., Jia W., Li J., Li J., Rui L., Yang L., and Liu Y. (2014) Hepatic IRE1α regulates fasting/diet-induced metabolic adaptive programs through the XBP1-PPARα Axis. Nature communications 27;5:3528. (*Co-first author).

7. Cai J., Zhang X., Chen P., Li Y., Liu S., Liu Q., Zhang H., Song K., Liu J., Shan B.#, and Liu Y. # (2022) Inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury. J Biol Chem. 298(1) (# Co-corresponding author)

8.  Hepler C., Shan B., Zhang Q., Henry G.H., Shao M., Vishvanath L., Ghaben A.L., Mobley A.B., Strand D., Hon G., Gupta R.K. (2018) Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. Elife. 28;7. pii: e39636.

9.  Shao M., Hepler C., Zhang Q., Shan B., Vishvanath L., Henry G., Zhao S., An Y., Wu Y., Strand D., Gupta R.K. (2021) Pathologic HIF1 signaling drives adipose progenitor dysfunction in obesity. Cell Stem Cell. 28(4):685-701.

Institute of Translational Medicine, Zhejiang University
Address: 268 Kaixuan Road, Shangcheng District, Hangzhou City, Zhejiang Province
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