Chengyong Shen Laboratory
Chengyong Shen
Researcher, Doctoral Supervisor
Research Interests:
The mechanisms of synapse formation and synaptic plasticity,
The establishment of motor circuits
Chengyong Shen

Selected Publications

1. Wang A#, Chen C#, Mei C, Liu S, Xiang C, Fang W, Zhang F, Xu F, Chen S, Zhang Q,  Bai X, Lin A, Neculai D, Xia B, Ye C, Zou J, Liang T, Feng XH, Li X*, and Shen C*, Xu P*. cGAS-STING machinery senses lysosomal dysfunction and drives ubiquitous lysosomal storage disorders. Nat.Cell.Biol 2024 Jan 22

2. Shu X#, Wei C#, Tu WY#, Zhong K, Qi S, Wang A, Bai L, Zhang SX, Luo B, Xu ZZ, Zhang K*, Shen C*. Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. Cell Reports. 2023 Feb 16;42(2):112133.

3. Zhang K#, Wang A#, Zhong K#, Qi S, Wei C, Shu X, Tu WY, Xu W, Xiao Y, Chen A, Bai L, Zhang J, Luo B, Wang W*, Shen C*. UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model. Neuron. 2021 Jun 16;109(12):1949-1962.

4. Chen A, Bai L, Zhong K, Shu X, Wang A, Xiao Y, Zhang K, Shen C*. APC2CDH1 negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7. FASEB.J. 2020 Sep; 34(9):12009-12023.

5. Xiao Y, Zhang J, Shu X, Bai L, Xu W, Wang A, Chen A, Tu WY, Wang J, Zhang K, Luo B*, Shen C*. Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment. Hum.Mol.Genet. 2020 Jul 21; 29(11):1784-1796.


Institute of Translational Medicine, Zhejiang University
Address: 268 Kaixuan Road, Shangcheng District, Hangzhou City, Zhejiang Province
Tel: 0571-86971812 / 0571-88981576

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