2022
64. Jiangbo Wei *, Xianbin Yu* , Lei Yang*, Xuelian Liu *, Boyang Gao, Boxian Huang, Xiaoyang Dou, Jun Liu, Zhongyu Zou, XiaoLong Cui, LiSheng Zhang, Xingsen Zhao, Qinzhe Liu, P Cody He, Caraline Sepich-Poore, Nicole Zhong, Wenqiang Liu, Yanhe Li, Xiaochen Kou, Yanhong Zhao, You Wu, Xuejun Cheng, Chuan Chen, Yiming An, Xueyang Dong, Huanyu Wang, Qiang Shu, Ziyang Hao, Tao Duan, Yu-Ying He, Xuekun Li, Shaorong Gao#, Yawei Gao#, Chuan He#. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science 2022, 376:968-973.
63. Huang Xiaoli, Guo Hongfeng, Cheng Xuejun, Zhang Jinyu, Qu Wenzheng, Ding Qianyun, Sun Qihang, Shu Qiang, Li Xuekun. NAD+ Modulates the Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells via Akt Signaling Pathway. Cells. 2022, 11(8):1283. doi: 10.3390/cells11081283.
62. Qu Wenzheng, Li Qiang, Wang Mengxuan, Zhao Xingseng, Wu Jiangdong, Liu Diwen, Hong Shenghui, Yang Ying#, Shu Qiang#, Li Xuekun#. m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement. Front Cell Dev Biol. 2022,10:903179. doi: 10.3389/fcell.2022.903179.
2021
61. Qu Wenzheng, Zhuang Yingliang, Li Xuekun. The roles of epigenetic modifications in neurodegenerative diseases. Journal of Zhejiang University (Medical Sciences) 2021,50:642-650.
60. Zhang Jinyu*, Wu Dingwen*, Yang Rulai, Zhu Lin, Jiang Mengyi, Wang Wenjun, Li Xuekun, Jiang Xiaoling, Tong Fan, Shu Qiang. FMR1 allele frequencies in 51,000 newborns: a large‑scale population study in China. World Journal of Pediatrics 17(5) (doi: 10.1007/s12519-021-00473-6).
59. Qian Li*, Junchen Chen*, Feng Liang*, Jinyu Zhang, Wenzheng Qu, Xiaoli Huang, Xuejun Cheng, Xingsen Zhao, Zhanjun Yang, Shunliang Xu#, Xuekun Li#. RYBP Modulates Embryonic Neurogenesis Involving the Notch Signaling Pathway in a PRC1-Independent Pattern. Stem Cell Reports 16(11)
58. Weize Xu*, Xicheng Zhang*, Feng Liang*, Yuhang Cao, Ziyi Li, Wenzheng Qu, Jinyu Zhang, Yanhua Bi, Chongran Sun, Jianmin Zhang, Binggui Sun, Qiang Shu#, Xuekun Li#. Tet1 regulates astrocyte development and cognition of mice through modulating GluA1. Front Cell Dev Biol. 9:644375 (https://doi.org/10.3389/fcell.2021.644375).
57. Liqi Shu*, Xiaoli Huang*, Xuejun Cheng, Xuekun Li. Emerging roles of N6-methyladenosine modification in neurodevelopment and neurodegeneration. Cells, 10(10), 2694-2704.
56. Wencai Wang*, Xingsen Zhao*, Yanjiao Shao, Xiaoya Duan, Yaling Wang, Jialun Li, Jiwen Li, Dali Li, Xuekun Li#, Jiemin Wong#. Mutation-induced DNMT1 cleavage drives neurodegenerative disease. Science Advances, 7(36):eabe8511.
55. Hui Shen*, Xingsen Zhao*, Junchen Chen, Wenzheng Qu, Xiaoli Huang, Mengxuan Wang, Zhiyong Shao, Qiang Shu#, Xuekun Li#. O-GlcNAc transferase Ogt regulates embryonic neuronal development through modulating Wnt/β-catenin signaling. Hum Mol Genet. 2021 Aug 4:ddab223. doi: 10.1093/hmg/ddab223.
54. Junchen Chen, Xiaoxue Dong, Xuejun Cheng, Qiang Zhu, Jinyu Zhang, Qian Li, Xiaoli Huang, Min Wang, Liping Li, Weixiang Guo, Bingui Sun, Qiang Shu#, Wen Yi#, Xuekun Li#. Ogt controls Neural Stem/Progenitor Cell Pool and Adult Neurogenesis Through Modulating Notch Signalling. Cell Reports 2021,34(13):108905 (doi: 10.1016/j.celrep.2021.108905.)
53. Huikang Tao*, Weize Xu*, Wenzheng Qu*, Hui Gao, Jinyu Zhang, Xuejun Cheng, Ning Liu, Jinghai Chen, Guo-liang Xu, Xuekun Li#, Qiang Shu#. Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulatign ERK signaling pathway. Hum Mol Genet 2021,ddab046 (doi: 10.1093/hmg/ddab046.).
52. Zhang X, Mei Y, He Y, Wang D, Wang J, Wei X, Yang E, Zhou D, Shen H, Peng G, Shu Q, Li X, Luo B, Zhou Y, Sun B. Ablating Adult Neural Stem Cells Improves Synaptic and Cognitive Functions in Alzheimer Models. Stem Cell Reports 2021,16(1):89-105.
2020
51. Chunyue Feng, Xiaoli Huang, Xuekun Li#, Jianhua Mao#. The Roles of Base Modifications in Kidney Cancer. Front Oncol 2020, 10:580018 (doi: 10.3389/fonc.2020.580018).
50. Xuejun Cheng, Fulai Guan, Qian Li, Haifeng Li, Xuekun Li#. AlCl3 exposure regulates neuronal development by modulating DNA modification. World J Stem Cells 2020,12(11): 1354-1365.
49. Yikai Shou*, Feng Liang*, Shunliang Xu#, Xuekun Li#. The Application of Brain Organoids: From Neuronal Development to Neurological Diseases. Front Cell Dev Biol 2020,8:579659 (doi: 10.3389/fcell.2020.579659).
48. Hui Gao, Xuejun Cheng, Junchen Chen, Chai Ji, Hongfeng Guo, Wenzheng Qu, Xiaoxue Dong, Yingyang Chen, Linghan Ma, Qiang Shu#, Xuekun Li#. Fto-modulated lipid niche regulates adult neurogenesis through modulating adenosine metabolism. Hum Mol Genet 2020,29(16):2775-2787.
47. Qiang Zhu, Xuejun Cheng, Yaxian Cheng, Junchen Chen, Huan Xu, Yuntao Gao, Xiaotao Duan, Junfeng Ji, Xuekun Li#, Wen Yi#. O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells. PNAS 2020,117(14):7755-7763 (doi/10.1073/ pnas.1915582117).
46. Yuhang Cao*,Yingliang Zhuang*, Junchen Chen, Weize Xu, Yikai Shou, Xiaoli Huang, Qiang Shu#, Xuekun Li#. Dynamic Effects of Fto in Regulating the Proliferation and Differentiation of Adult Neural Stem Cells of Mice. Hum Mol Genet 2020,29(5):727-735.
2019
45. Yingliang Zhuang, Junchen Chen, Weize Xu, Qiang Shu, Xuekun Li#. The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice. JoVE 2019,151,e59950.
44. Wang Y, Guo B, Xiao Z, Lin H, Zhang X, Song Y, Li Y, Gao X, Yu J, Shao Z, Li X, Luo Y, Li S. Long noncoding RNA CCDC144NL-AS1 knockdown induces naive-like state conversion of human pluripotent stem cells. Stem Cell Res Ther 2019,10(1):220.
43. Junchen Chen*, Yichang Zhang*, Chunmin Huang*, Hui Shen, Baofa Sun, Xuejun Cheng, Yujie Zhang, Yungui Yang, Qiang Shu#, Ying Yang#, Xuekun Li#. mRNA Methyltransferase Mettl3 Regulates Neurogenesis and Neuronal Development via Modulating Histone Methyltransferase Ezh2. Genomics, Proteomics & Bioinformatics 2019,17(2):154-168.
42. Zhang X., Zhao X., Shu L., Li X. Autism spectrum disorders: autistic phenotypes, complicated mechanisms. World J Pediatrics 2019. Doi: 10.1007/s12519-018-0210-2.
41. Ling Li, Yingliang Zhuang, Xingsen Zhao, Xuekun Li. Long Noncoding RNA: Characterization and Biological Function in Development and Human Disease. Frontiers in Genetics 2019 (https://doi.org/10.3389/fgene.2018.00744)
2018
40. Li Y, Park C, Jiang H, Li X, Vellón L. Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis. Int J Genomics 2018 Sep 24.
39. Li M, Zhang S, Zhao W, Hou C, Ma X, Li X, Huang B, Chen H, Chen D. RYBP modulates stability and function of Ring1B through targeting UBE3A. FASEB J 2018, 33(1):683-695.
38. Cheng Y, Li Z, Manupipatpong S, Lin L, Li X, Xu T, Jiang YH, Shu Q, Wu H, Jin P. 5-hydroxymethylcytosine alterations in the human postmortem brains of autism spectrum disorder. Hum Mol Genet 2018,27(17):2955-2964.
37. Tao H, Xie P, Cao Y, Shu L, Li L, Chen J, Tian G, Zhuang Y, Shu Q#, Li X# . The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation. Stem Cells Int 2018: 2186301.
2017
36. Li X#, Yao B, Chen L, Kang Y, Li Y, Cheng Y, Li L, Lin L, Wang Z, Wang M, Pan F, Dai Q, Zhang W, Wu H, Shu Q, Qin Z, He C, Xu M, Jin P#. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nature Communications 2017, 8:15903. (co-correspondence)
35. Li L, Zang L, Zhang F, Chen J, Shen H, Shu L, Liang F, Feng C, Chen D, Tao H, Xu T, Li Z, Kang Y, Wu H, Tang L, Zhang P, Jin P#, Shu Q#, Li X#. Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Hum Mol Genet 2017,26(13):2398-2411. (co-correspondence)
34. Liqi Shu, Wenjia Sun, Liping Li, Zihui Xu, Li Lin, Pei Xie, Hui Shen, Luoxiu Huang, Qi Xu, Peng Jin, Xuekun Li. Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s disease. BMC Genomics 2017,17(1):381-391.
2015
33. Zhang P, Zhang L, Zhu L, Chen F, Zhou S, Tian T, Zhang Y, Jiang X, Li X, Zhang C, Xu L, Huang F. The change tendency of PI3K/Akt pathway after spinal cord injury. Am J Transl Res 2015,15;7(11):2223-3222.
2014
32. Li, H., Zhong, X., Chau, KF., Santistevan, NJ., Guo,WX., Kong, GY., Li, X. , Kadakia, M., Masliah,J., Chi,JY., Jin, P., Zhang, J., Zhao, XY., Chang, Q. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nature communications 2014,5:5601-5610.
31. Sun, W*., Zang, L*., Shu, Q., Li., X. From development to diseases: The role of 5hmC in brain. Genomics 2014,104:347-351.
30. Sun, W., Guan, M., and Li, X. 5-hydroxymethylcytosine mediated DNA demethylation in stem cells and development. Stem cells and Dev 2014,23:923-930.
2013 and before
29. Xu, Z., Poidevin, M., Li, X., Li, Y., Shu, L., Nelson, DL., Li, H., Hales, CM., Gearing, M., Wingo, TS., Jin, P. Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration. Proc Natl Acad Sci USA 2013,110:7778-7783.
28. Wang. T., Wu, H., Li, Y., Szulwach, KE., Lin, L., Li, X., Chen, I., Goldlust, I., Chamberlain, S., Ananiev, G., Mowrey, J., Han, J., Kim, M., Yoon,Y., Rudd, M., Song, C., He, C., Chang, Q., Warren, S., Jin, P. Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nature Cell biology 2013,15:700-711.
27. Hong,Y., Chan, CB., Kwon, IS., Li, X., Song, M., Lee, HP., Liu, X., Sompol, P., Jin, P., Lee, HG., Yu, SP., Ye, K. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci 2012,32:17262-12772.
26. Wang, T., Pan, Q., Lin L, Szulwach, KE., Song, CX., He, C., Wu, H., Warren, ST., Jin, P., Duan, R., Li, X. Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum. Hum Mol Genet 2012,21,5500-5510.
25. Yu, M., Hon, G., Szulwach, K., Song, C., Zhang, L., Kim, A., Li, X., Dai, Q., Park, B., Min, J., Jin, P., Ren, B., He, C. Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome. Cell 2012,149,1368-1380.
24. Xu,Z., Li, X. DNA Methylation in Neurodegenerative Disorders. Curr Tran Geriatr Gerontol 2012,1:199–205.
23. Szulwach, K.E*., Li, X*., Li, Y., Song, C.X., Wu, H., Dai, Q., Irier, H., He, C. and Jin, P. 5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging. Nature Neuroscience 2011,14:1607-1616 (* equal contribution).
22. Szulwach, KE., Li, X, Li, Y., Song, CX., Han, JW., Kim, S., Namburi,S., Hermetz, K., Kim, JJ., Rudd, MK., Yoon, YS., Ren, B., He, C., Jin, P. Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet 2011, 7: e1002154.
21. Qurash,A., Li, X*., Jin, P*. (2011) Fragile X Mental Retardation Protein and Stem Cells. (* co-corresponding author; Robert B. Denman edited, Springer)
20. Song, C.X., Szulwach, K.E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T.J., Zhang, B., Godley, L.A., Hicks, L.M., Lahn, B.T., Jin, P., and He, C. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nature Biotechnology 2011, 29,68-72.
19. Li, X. and Jin, P. Roles of small regulatory RNAs in determining neuronal identity. Nature Reviews Neurosci 2010,11:329-338.
18. Luo, Y., Shan, G., Guo, W., Smrt, R.D., Johnson, E., Li, X., Duan, R., Barkho, B.Z., Li, W., Jin, P., and Zhao, X. Fragile X mental retardation protein regulates adult neurogenesis. PLoS Genetics 2010,6: e1000898.
17. Smrt, RS., Szulwach, KE., Pfeiffer, RL., Li, X., Guo, W., Pathania, M., Luo, Y., Wilson, MC., Bordey, A., Jin, P., and Zhao, X. MicroRNA miR-137 modulates neuronal maturation through translational regulation of Mind Bomb-1. Stem Cells 2010,28:1060-1070.
16. Szulwach, KE*., Li, X*., Smrt, RS., Li, Y., Luo, Y., Lin, L., Santistevan, N., Li, W., Zhao X., and Jin, P. MeCP2-mediated crosstalk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biology 2010,189:127-141(*equal contribution).
15. Li, X., and Jin, P. (2009) Macro role(s) of microRNAs in fragile X syndrome? Neuromolecular Med 11:200-207.
14. Barkho, B., Munoz., A., Li, X., Li, L., Cunningham, L., and Zhao, X. Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 mediate the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells 2008,26: 3139-3149.
13. Li, X., Tang, X., Jablonska, B., Aguirre, A., Gallo, V., and Luskin, M. p27KIP1 Regulates Neurogenesis in the Rostral Migratory Stream and Olfactory Bulb of the Postnatal Mouse. J Neurosci 2009,29:2902-2914.
12. Szulwach, K., Li, X., Zhao, X, Jin, P. (2009) Epigenetic Regulation of miRNA in Stem Cells. Current Perspective in miRNAs, (Springer).
11. Li, X., Barkho. BZ., Luo, Y., Smrt, RD., Santistevan, NJ., Liu, C., Kuwabara, T., Gage, FH., Zhao, X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem 2008,283:27644-27652.
10. Allan, A., Liang, X., Luo, Y., Pak, C., Li, X., Szulwach, K., Chen, D., Jin, P., Zhao, X. The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Hum Mol Genet 2008, 17:2047-2057.
9. Li, X., Zhao, X. Epigenetic Regulation of mammalian stem Cells. Stem Cells Dev 2008,17:1043-1052.
8. Li, X., Barkho, BZ., Zhao, X. (2008) Neural stem cells and neurogenic niche in the adult brain. Stem Cell Research and Therapeutics edited by Shi Y and Clegg D. Springer.
7. Kong, X., Li, X., Cai, Z., Yang, N., Liu, Y., Shu, J., Pan, J., Zuo, P. Melatonin regulates viability and differentiation of rat midbrain neural stem cells. Cellular and Molecular Neurobiology 2008, 28:569-579.
6. Tang, X*., Falls, L*., Li, X., Lane, T., and Luskin, MB. Antigen-Retrieval Procedure for Bromodeoxyuridine Immunolabeling with Concurrent Labeling of Nuclear DNA and Antigens Damaged by HCl Pretreatment. J Neurosci 2007,27:5837-5844.
5. Cui, X., Zuo, P., Zhang, Q., Li, X., Hu, Y., Long, J., Packer, L., Liu, J. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-alpha-lipoic acid. J Neurosci Res 2006,83:1584-1590.
4. Zhang Q., Huang Y., Li, X., Cui X., Zuo P. and Li J. GM1 ganglioside prevented the decline of hippocampal neurogenesis associated with D-galactose. Neuroreport 2005, 16:1297-1301.
3. Zhang Q*., Li, X*., Cui X. and Zuo P. D-Galactose injured neurogenesis in the hippocampus of adult mice. Neurol Res 2005,27: 552-556.
2. Li, X., and Zuo P. Effects of Aβ25-35 on neurogenesis in the adult mouse subventricular zone and dentate gyrus. Neurol Res 2005,27: 218-222.
1. Li, X., Guo A. and Zuo P. Survival and differentiation of transplanted neural stem cell in the brain of MPTP-induced Parkinson’s disease model mouse. ACTA PHARMACOLOGICA SINICA 2003,24:1192-1198.
