Ping Liang Laboratory
Ping Liang
Professor, Doctoral Supervisor
Research Interests:
Directed differentiation of human pluripotent stem cells
into cardiovascular cells
Ping Liang

Selected Publications

1)        Tang L, Fang Yao F, Wang H, Wang X, Shen J, Dai B, Wu H, Zhou D, Guo F, Wang J, Li T, Wang H, Gong T, Su J*, Wang L*, Liang P*.Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes. JMCC 2018(已接收)

2)        Luo L, Li B, Wang S, Wu F, Wang X, Liang P, Ombati R, Chen J, Lu X, Cui J, Lu Q, Zhang L, Zhou M, Tian C, Yang S, Lai R. Centipedes subdue giant prey by blocking KCNQ channels.PNAS2018;115(7):1646-1651

3)        Shen J, Wang X, Zhou D, Li T, Tang L, Gong T, Su J, Liang P. Modeling cadmium-induced cardiotoxicity using human pluripotent stem cell-derived cardiomyocytes.JCMM2018;22(9):4221-4235

4)        Tang L*, Su J*, Liang P. Modeling cadmium-induced endothelialtoxicity using human pluripotent stemcell-derived endothelial cells. Scientific Reports2017;7(1):14811*共同第一作者)

5)        Li B*, Yang H*, Wang X*, Zhang Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G#, Liang P#, Sun N#. Engineering human ventricular heartmuscles based on a highly efficient systemfor purification of human pluripotent stemcell-derived ventricular cardiomyocytes. Stem Cell Research & Therapy2017; 8 (1):202*共同第一作者)(#共同通讯作者)

6)        Liang P*#, Sallam K*, Wu H*, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churco J, Hu S, Sharma A, Lam CK, Scheinmman MM, Bers DM, Wu JC#. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell–Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. JACC 2016; 68 (19): 2086-2096*共同第一作者)(#共同通讯作者)

7)        Wu S, Zhu Y, Liu H, Tang L, Du R, Shen Y, Feng J, Zhang K, Xu C, Zhang S, Chen Y, Song F, Zhu Y, Gu W, Liang P, Carrio I, Zhang H, Tian M. In vivo dynamic metabolic changes after induced pluripotent stem cells for ischemia injury. Journal of Nuclear Medicine 2016; 57 (12): 2012-2015

8)        Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, Almeida PE, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Science Translational Medicine 2014; 6 (255): 255ra130

9)        Sharma A, Marceau CD, Hamaguchi R, Burridge P, Rajarajan K, Churko J, Wu H, Sallam K, Matsa E, Sturzu A, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circulation Research 2014; 115 (6): 556-66

10)    Wang Y*, Liang P*,Lan F*, Wu H*, Lisowski L, Gu M, Hu S, Kay M, Urnov F, Shinnawi R, Gold J, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates Long QT phenotype for drug testing. JACC 2014; 64(5): 451-9*共同第一作者)

11)    Sanchez VF, Lee AS, Hu S, Abilez OJ, Liang P, Lan F, Huber B, Ong S, Hong W, Huang M, Wu JC. Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. JACC 2014; 64(5):436-48

12)    Liang P, Du J. Human induced pluripotent stem cell for modeling cardiovascular diseases. Regenerative Medicine Research 2014; 2:4 

13)    Navarrete EG*, Liang P*, Lan F*, Sanchez-Freire V, Simmons CS, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Beygui RE, Bers DM, Wu JC. Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 2013; 128: S3-S13*共同第一作者)

14)    Tang Y, Liang P, Zhou J, Lu Y, Lei L, Bian X, and Wang K. Auxiliary KChIP4a suppresses A-type K+ current through ER retention and promoting closed-state inactivation of Kv4 channels. Journal of Biology Chemistry 2013; 288(21):14727-41

15)    Liang P*, Lan F*, Lee AS*, Gong T, Sanchez VF, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell derived cardiomyocytes reveals disease specific patterns of cardiotoxicity. Circulation 2013; 127 (16): 1677-1691(由Dan RodenCharles Hong配发评论)(2013 年度基础研究领域最佳论文)*共同第一作者)

16)    Lan F*, Lee AS*, Liang P*, Sanchez VF, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell 2013; 12 (1): 101-13Faculty 1000推荐“必读”文章)*共同第一作者)

17)    Wang Y, Zhang W, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, Almeida PE, Won J, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circulation Research 2012; 111 (12): 1494-503(封面文章)(由G CourtiesM Nahrendorf配发评论)

18)    Ebert AD, Liang P, Wu JC.Induced pluripotent stem cells as a disease modeling and drug screening platform. Journal of Cardiovascular Pharmacology2012; 60 (4): 408-16

19)    Liang P, Chen H, Cui Y, Wang K. Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a. Biophysical Journal 2010; 98 (12): 2867-76

20)    Zhang Y*, Su P*, Liang P, Liu T, Liu X, Liu X, Zhang B, Han T, Zhu Y, Yin D, Li J, Zhou Z, Wang K, Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. Journal of Neuroscience 2010; 30 (22): 7575-86*共同第一作者)

21)    Liang P*, Wang H*, Chen H*, Cui Y, Gu L, Chai J, Wang K. Structural insights into KChIP4a modulation of Kv4.3 inactivation.Journal of Biology Chemistry 2009; 284 (8): 4960-4967*共同第一作者)

22)    Cui Y, Liang P, Wang K. Enhanced trafficking of tetrameric Kv4.3 channels by KChIP1 clamping. Neurochemical Research 2008; 33 (10): 2078-84

Institute of Translational Medicine, Zhejiang University
Address: 268 Kaixuan Road, Shangcheng District, Hangzhou City, Zhejiang Province
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