Haibo Wang, PhD
Principal Investigator
Institute of Translational Medicine, School of Medicine, Zhejiang University
Research Experience
2022 – present Institute of Translational Medicine, Zhejiang University, Principal Investigator
2017 – 2022 Max-Planck Institute of Biophysical Chemistry, Germany, Postdoc
2015 – 2017 ETH Zurich, Switzerland, Postdoc
Education
2010 –2015 School of Medicine, Tsinghua University, China, Ph.D.
2006 –2010 School of life Sciences, Jilin University, China, B.S.
Research Interest
1. Molecular mechanism of epigenetic regulation.
2. Pathogenic mechanism of epigenetic deregulation in diseases.
Research Field
Epigenetic regulation controls the interpretation of genetic information in the context of chromatin and plays an important role in fundamental molecular processes including gene transcription, DNA replication and repair. Our research field is focused on the mechanistic studies of the epigenetic complexes involved in gene expression regulation in eukaryote and have made several major academic achievements, including determination the first structure of the Spt-Ada-Gcn5 acetyltransferase (SAGA) transcription coactivator complex to elucidate its assembly and chromatin recognition mechanism, and determination the structures of the several transcription factors or cofactors in complex with nucleosome to reveal the mechanism of nucleosome recognition.
However, the structural basis and regulation mechanism by which a variety of epigenetic modifications are established and exert their function in chromatin context during the transcription process remain largely unknown, limiting our understanding of fine-tuning of the transcription. Our future research aims to answer key mechanistic questions at the intersection of chromatin and transcription. We employ molecular biology, biochemistry, and structural biology approaches to understand how the transcription machinery, epigenetic factors, and the chromatin crosstalk with each other to establish and retain epigenetic landscape, and the dynamics of the chromatin structure during gene expression. Another aim of my research is to elucidate how deregulation of epigenetic modifications leads to human disease such as leukemia.
