Haibo Wang Laboratory
Haibo Wang
Research Interest:
1.Molecular mechanism of epigenetic regulation.
2.Pathogenic mechanism of epigenetic deregulation in diseases.
Haibo Wang

Selected Publications

   (#first author, *corresponding author)

  1. W. Li, H. Cui, Z. Lu and H. Wang*, Structure of histone deacetylase complex Rpd3S bound to nucleosome. Nat  Struct Mol Biol, 2023, https://doi.org/10.1038/s41594-023-01121-5

  2. J. Abril-Garrido, C. Dienemann, F. Grabbe, T.  Velychko, M. Lidschreiber, H. Wang*, P. Cramer*, Structural basis of transcription reduction by a promoter-proximal +1  nucleosome. Mol Cell, 2023, 83(11):1798-1809

  3. S. Schilbach#H. Wang#, C. Dienemann and P. Cramer, Yeast PIC-Mediator structures with RNA polymerase II C-terminal domain. Proc Natl Acad Sci, 2023, 120 (15) e2220542120

  4. H. Wang, S. Schilbach, M. Ninov, H. Urlaub and P. Cramer,  Structures of transcription preinitiation complex engaged with the +1  nucleosome. Nat Struct Mol Biol, 2023, 30(2):226-232 

  5. H. Wang, L. Xiong and P. Cramer, Structures and implications of  TBP-nucleosome complexes. Proc Natl Acad Sci, 2021,  118(30)e2108859118112021

  6. H. Wang, L. Farnung, C. Dienemann and P. Cramer, Structure of  H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre  binding. Nat Struct Mol Biol, 2020, 27(1):8-13

  7. H. Wang, C. Dienemann, A. Stutzer, H. Urlaub, A. C. M. Cheung and P. Cramer, Structure of the transcription coactivator SAGA. Nature,  2020, 577(7792):717-720

  8.  F. R. Wagner, C. Dienemann, H. Wang, A. Stutzer, D. Tegunov, H. Urlaub and P. Cramer, Structure of SWI/SNF  chromatin remodeller RSC bound to a nucleosome. Nature,  2020, 579(7799):448-451

  9.  K. M. Noh#H. Wang#,  H. R. Kim, W. Wenderski, F. Fang, C. H. Li, S. Dewell, S. H. Hughes, A. M. Melnick, D. J. Patel, H. Li and C. D. Allis, Engineering of a  Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs. Mol Cell, 2015, 59(1):89-103

  10.  Y. Li#, H. Wen#, Y. Xi, K. Tanaka, H. Wang, D. Peng, Y. Ren, Q. Jin, S. Y. Dent, W. Li, H. Li and X. Shi, AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell, 2014,  159(3):558-71

 

 



Institute of Translational Medicine, Zhejiang University
Address: 268 Kaixuan Road, Shangcheng District, Hangzhou City, Zhejiang Province
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