Research Field
Tumor cells achieve rapid growth by changing their metabolic patterns. This important feature is known as cancer metabolic reprogramming. Metabolic enzymes could acquire new non-metabolic functions because of the numerous gene mutations and unique microenvironment in tumors. We will focus on investigating the key scientific questions for tumor metabolism through the cutting-edge techniques in biochemistry, molecular biology, metabolomics, and transgenic/knockout mice with tumor models. We will carry out basic research in synthesis and catabolism of biological macromolecules, redox homeostasis, the molecular and spatial network for metabolic enzyme, the tumor microenvironment and metabolite sensing, etc. By studying the molecular mechanism of metabolic reprogramming, we will reveal new metabolic markers and molecular targets for cancer, and provide a theoretical basis for individualized treatment of cancer. In addition, we will develop anti-tumor drugs and corresponding diagnostic reagents targeting metabolic enzymes. The translational research will eventually be used in the diagnosis and treatment of tumor patients.
We have three research directions in cancer metabolism:
(1) Dissect the molecular network in the metabolic reprogramming
(2) Study the spatial regulation and post-translational modification in cancer metabolism
(3) Uncover the non-metabolic function of metabolic enzyme in tumorigenesis
Education Background
2011-2016 Ph.D. (Master-Ph.D. continuous study):
Shanghai Institute for Biological Sciences (SIBS),
Chinese Academy of Science. Shanghai, China (CAS)
2007~2011 Bachelor: Xiamen University, China
Working Experience
2020 ～present
Institute of Translational Medicine, University School of Medicine, Zhejiang University/
The First Affiliated Hospital, Zhejiang University, Principle Investigator/ Doctoral supervisor
2017~2020
MD Anderson Cancer Center, Postdoc fellow
2016~2017
New York University School of Medicine/ Howard Hughes Medical Institute (HHMI), Postdoc fellow
Honors during postdoc training (2016～2020)：
2017 Odyssey fellowship in MD Anderson Cancer Center, USA
(~180,000 dollars funding support from Sep, 2017~ Sep, 2020.
Only three Top postdoc fellows was awarded this funding support in MD Anderson Cancer Center every year)
Honors during Master-Ph.D. continuous study (2011～2016)：
2016 Outstanding graduates in Shanghai, China
2016 Merit Student of Chinese Academy of Sciences
2016 Zhuli Yuehua Scholarship for Ph.D. graduates, China
2016 First Prize for the New World Scholarship, Hong Kong, China
2016: 1st Prize in the 12th session of the youth forum of cell biology, Shanghai, China
2015 National Scholarship for Ph.D. candidate
2015 Merit Student of Chinese Academy of Sciences
2013 National Scholarship for M.S. candidate
2013 Excellent Student Cadre of Chinese Academy of Sciences
2013 Merit Student of Chinese Academy of Sciences
Honors during Bachelor study (2007～2011)：
2010 The scholarship of Xia-Men University, China
