Daqian Xu Laboratory
Daqian Xu
Principle Investigator, Doctoral supervisor
Daqian Xu

Selected Publications

1.Duan Y*, Hu Z*, Han P*, Lei B*, Wang S*, Hou Y, Lin Y, Li M, Xiao L, Wu Q, Meng Y, Liu G, Lou S, Yang L, Bai X, Duan S, Zhan P, Liu T, Lu Z, and Xu D#. ADSL-generated fumarate binds and inhibits STING to promote tumor immune evasion. Nature Cell Biology. in press. (*co-first author, #corresponding author)(唯一通讯)

2.Wang L*, Shi R*, Wang S*, Duan Y*, Wang Z*, Zheng P, Sun X, Chen X, Ji G, Shen Y, Dong B, Lin Y, Wen T, Tian Q, Guo Z, Hou Y, Wu S, Xiao L, Li M, Xiao LW, Wu Q, Meng Y, Liu G, Duan S, Bai X, Liu T, Zhang Z, Zhan P, Lu Z, and Xu D#. ADSL promotes autophagy and liver tumor growth through fumarate-mediated Beclin1 dimethylation. Nature Chemical Biology. in press. (*co-first author, #corresponding author)(唯一通讯)

3.Wu K*, Yan M*, Liu T*, Wang Z*, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q#, Lu Zand Xu D#. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nature Cell Biology. (2023) May;25(5):714-725. (*co-first author, #co-corresponding author)(最后通讯)

4.Liu T*, Wang Z*, Ye L*, Duan Y*, Jiang H, He H, Xiao L, Wu Q, Xia Y, Yang M, Wu K, Yan M, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Shao F, Qian X, Yu R, Zhang Z, Lu Zand Xu D#. Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. Nature Cell Biology. (2023) Feb;25(2):273-284. (*co-first author, #co-corresponding author) (最后通讯)

5.Wang Z*, Yan M*, Ye L*, Zhou Q*, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B#, Lu Z# and Xu D#. VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation. The EMBO Journal. (2024) Mar;43(6):931-955.(*co-first author, #co-corresponding author) (最后通讯)

6.Meng Y*, Guo D*, Lin L*, Zhao H, Xu W, Luo S, Jiang X, Li S, He X, Zhu R, Shi R, Xiao L, Wu Q, He H, Tao J, Jiang H, Wang Z, Yao P, Xu D#, Lu Z#. Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance β-oxidation and tumor cell proliferation. Nature Metabolism. 2024 Jun;6(6):1092-1107. (共同通讯

7.Li M*, Wang Z*, Tao J*, Jiang H, Yang H, Guo D, Zhao H, He X, Luo S, Jiang X, Yuan L, Xiao L, He H, Yu R, Fang J, Liang T, Mao Z, Xu D# and Lu Z#. Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. Nature Chemical Biology. (2024) Mar; Online ahead of print. (*co-first author, #co-corresponding author) (共同通讯)

8.Wang Z, Ma L, Meng Y, Fang J#, Xu D#, Lu Z#. The interplay of the circadian clock and metabolic tumorigenesis. Trends in Cell Biology. (2024)Sep;34(9):742-755.  (#co-corresponding author)(共同通讯)

9.Wang Z*, Li M*, Jiang H, Luo S, Shao F, Xia Y, Yang M, Ren X, Liu T, Yan M, Qian X, He H, Guo D, Duan Y, Wu K, Wang L, Ji G, Shen Y, Li L, Zheng P, Dong B, Fang J, Zheng M, Liang T, Li H, Yu R, Xu Dand Lu Z#. Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth. Nature Cell Biology. (2022) Nov;24(11):1655-1665. (*co-first author, #co-corresponding author) (共同通讯)

10.Xu D*, Shao F*, Bian X*, Meng Y, Liang T and Lu Z. The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies. Cell Metabolism. (2021) Jan 5;33(1):33-50.(*co-first author) (第一作者)

11.Bian X*, Liu R*, Meng Y*, Xing D#Xu Dand Lu Z#. Lipid metabolism and cancer. Journal of Experimental Medicine. (2021) Jan 4;218(1):e20201606. (*co-first author, #co-corresponding author) (共同通讯)

12.Xu D*#, Wang Z*, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung MCand Lu Z#. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. (2020) Apr;580(7804):530-535. (*co-first author, #co-corresponding author) (第一作者兼共同通讯)



Institute of Translational Medicine, Zhejiang University
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