Jun Xu Laboratory
Jun Xu
Researcher, Doctoral Supervisor
Research Interests: Molecular mechanisms of transcriptional regulation
in eukaryotes; Pathological mechanisms and translational applications
of cancer and neurodegenerative diseases studies caused
by transcription dysregulation.
Jun Xu

Selected Publications

1. Jun Xu#, Indrajit Lahiri#, Wei Wang, Adam Wier, Michael A. Cianfrocco, Jenny Chong, Alissa A. Hare, Peter B. Dervan, Frank DiMaio, Andres E. Leschziner & Dong Wang. (2017) Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 551, 653-657. 

2. Jun Xu, Jenny Chong, Dong Wang. (2021) Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures. Nucleic Acids Res. 49, 4944-4953. 

3. Jun Xu, Jenny Chong, Dong Wang. (2021) Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs. Nucleic Acids Res. 49, 7618-7627. 

4. Jun Xu, Wei Wang, Liang Xu, Jia-Yu Chen, Jenny Chong, Juntaek Oh, Xiang-Dong Fu, Dong Wang. (2020) Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps elongating RNA polymerase II overcome nucleosome barriers. Proc. Natl. Acad. Sci. USA. 117, 25486-25493. 

5. Carmen Ka Man Tse#, Jun Xu#, Liang Xu, Fu Kit Sheong, Shenglong Wang, Peter Pak- Hang Cheung, Dong Wang, Yingkai Zhang, Xuhui Huang. (2019) Intrinsic cleavage of RNA Polymerase II adopts a nucleobase-independent mechanism assisted by transcript phosphate. Nature Catalysis. 2, 228–235. 

6. Wei Wang#, Jun Xu#, Oliver Limbo#, Jia Fei#, George A. Kassavetis, Jenny Chong, James T. Kadonaga, Paul Russell, Bing Li, Dong Wang. (2019) Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog. Proc. Natl. Acad. Sci. USA. 116, 6120-6129. 

7. Marta Sanz-Murillo#, Jun Xu#, Georgiy A. Belogurov, Olga Calvo, David Gil-Carton, Marí Moreno-Morcillo, Dong Wang, and Carlos Fernández-Tornero. (2018) Structural basis of RNA polymerase I stalling at UV light-induced DNA damage. Proc. Natl. Acad. Sci. USA. 115, 8972-8977. Selected as the Cover paper. 

8. Jun Xu, Chen Shen, Tao Wang, Junmin Quan. (2013) Structural basis for the inhibition of Polo-like kinase 1. Nat. Struct. Mol. Biol. 20, 1047-1053. Highlighted in the cover and reported by Nature China. 


Institute of Translational Medicine, Zhejiang University
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